Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPM1K

Summary for PPM1K

Gene information	Gene symbol	PPM1K
	Ensembl ID	ENSG00000163644
	Entrez ID	152926
	Gene name	protein phosphatase, Mg2+/Mn2+ dependent 1K
	Synonyms	BDP\|DKFZp761G058\|hPTMP\|PP2Ckappa\|PP2Cm
	Gene type	protein_coding
	UniProtAcc	Q8N3J5

Top

Dataset with differentially expressed gene: PPM1K

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.317962	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.385379	9.60e-25
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.294855	0.00e+00

Top

Expression of PPM1K in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PPM1K

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PPM1K

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPM1K	hsa-miR-23c	98.673	NM_152542
PPM1K	hsa-miR-23b-3p	98.673	NM_152542
PPM1K	hsa-miR-23a-3p	98.673	NM_152542
PPM1K	hsa-miR-4789-3p	97.7306	NM_152542
PPM1K	hsa-miR-3613-3p	97.1351	NM_152542
PPM1K	hsa-miR-211-5p	96.9168	NM_152542
PPM1K	hsa-miR-204-5p	96.9168	NM_152542
PPM1K	hsa-miR-548x-3p	95.8253	NM_152542
PPM1K	hsa-miR-548aj-3p	95.8253	NM_152542
PPM1K	hsa-miR-6738-3p	95.7102	NM_152542
PPM1K	hsa-miR-3133	95.2499	NM_152542
PPM1K	hsa-miR-4666a-3p	94.609	NM_152542
PPM1K	hsa-miR-548j-3p	94.6049	NM_152542
PPM1K	hsa-miR-548ae-3p	94.6049	NM_152542
PPM1K	hsa-miR-548aq-3p	94.6049	NM_152542
PPM1K	hsa-miR-548am-3p	94.6049	NM_152542
PPM1K	hsa-miR-548ah-3p	94.6049	NM_152542
PPM1K	hsa-miR-22-3p	92.8303	NM_152542
PPM1K	hsa-miR-616-5p	92.138	NM_152542
PPM1K	hsa-miR-371b-5p	92.138	NM_152542
PPM1K	hsa-miR-373-5p	92.138	NM_152542
PPM1K	hsa-miR-4760-5p	90.8343	NM_152542
PPM1K	hsa-miR-4470	89.5375	NM_152542
PPM1K	hsa-miR-8061	89.3223	NM_152542
PPM1K	hsa-miR-548c-3p	89.1129	NM_152542
PPM1K	hsa-miR-466	88.6311	NM_152542
PPM1K	hsa-miR-222-5p	88.0311	NM_152542
PPM1K	hsa-miR-7153-5p	87.8878	NM_152542
PPM1K	hsa-miR-623	87.3152	NM_152542
PPM1K	hsa-miR-4789-5p	86.9439	NM_152542
PPM1K	hsa-miR-3662	86.768	NM_152542
PPM1K	hsa-miR-3680-3p	84.7761	NM_152542
PPM1K	hsa-miR-24-3p	84.5345	NM_152542
PPM1K	hsa-miR-642b-5p	84.2317	NM_152542
PPM1K	hsa-miR-146a-5p	84.2163	NM_152542
PPM1K	hsa-miR-146b-5p	84.2163	NM_152542
PPM1K	hsa-miR-4307	84.1027	NM_152542
PPM1K	hsa-miR-7151-3p	84.0527	NM_152542
PPM1K	hsa-miR-627-3p	83.8039	NM_152542
PPM1K	hsa-miR-6832-3p	83.1436	NM_152542
PPM1K	hsa-miR-5688	82.9513	NM_152542
PPM1K	hsa-miR-1284	82.6713	NM_152542
PPM1K	hsa-miR-1827	82.0017	NM_152542
PPM1K	hsa-miR-4534	80.675	NM_152542
PPM1K	hsa-miR-3120-3p	80.2756	NM_152542

Page: 1

Top

Motifs and transcription factors (TFs) regulating PPM1K

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPM1K	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PPM1K	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PPM1K	transfac_pro__M02089	E2F3 (directAnnotation).
PPM1K	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PPM1K	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PPM1K	transfac_pro__M04817	ZBTB33 (directAnnotation).
PPM1K	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PPM1K	tfdimers__MD00483	ZBTB14 (directAnnotation).
PPM1K	cisbp__M07938	E2F1 (directAnnotation).
PPM1K	cisbp__M00968	MTF2 (directAnnotation).
PPM1K	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PPM1K	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PPM1K	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PPM1K	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPM1K	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PPM1K	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
PPM1K	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PPM1K	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
PPM1K	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
PPM1K	transfac_pro__M04887	TCF12 (directAnnotation).
PPM1K	tfdimers__MD00026	IRF1; MYB (directAnnotation).
PPM1K	metacluster_167.7	IRF8 (inferredBy_Orthology).
PPM1K	transfac_pro__M01239	RELA (directAnnotation).
PPM1K	transfac_pro__M06181	ZNF165 (directAnnotation).
PPM1K	transfac_pro__M06234	ZNF91 (directAnnotation).
PPM1K	metacluster_84.16	RARB (directAnnotation).
PPM1K	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
PPM1K	metacluster_84.18	RARA (directAnnotation).
PPM1K	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
PPM1K	transfac_pro__M06408	ZSCAN30 (directAnnotation).
PPM1K	transfac_pro__M06741	ZNF70 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."