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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPM1D

Summary for PPM1D

Gene information	Gene symbol	PPM1D
	Ensembl ID	ENSG00000170836
	Entrez ID	8493
	Gene name	protein phosphatase, Mg2+/Mn2+ dependent 1D
	Synonyms	PP2C-DELTA\|Wip1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPM1D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.327649	0.00e+00

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Expression of PPM1D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPM1D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPM1D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPM1D	hsa-miR-12136	99.2815	NM_003620
PPM1D	hsa-miR-4680-3p	98.641	NM_003620
PPM1D	hsa-miR-5692a	98.462	NM_003620
PPM1D	hsa-miR-892a	96.7223	NM_003620
PPM1D	hsa-miR-300	95.2929	NM_003620
PPM1D	hsa-miR-381-3p	95.2929	NM_003620
PPM1D	hsa-miR-921	94.4429	NM_003620
PPM1D	hsa-miR-32-3p	93.8606	NM_003620
PPM1D	hsa-miR-548ar-3p	93.4952	NM_003620
PPM1D	hsa-miR-217-5p	93.2283	NM_003620
PPM1D	hsa-miR-3163	93.0245	NM_003620
PPM1D	hsa-miR-6779-3p	92.9238	NM_003620
PPM1D	hsa-miR-29a-5p	92.4905	NM_003620
PPM1D	hsa-miR-2115-3p	92.255	NM_003620
PPM1D	hsa-miR-873-3p	92.1146	NM_003620
PPM1D	hsa-miR-98-3p	90.6259	NM_003620
PPM1D	hsa-let-7a-3p	90.6259	NM_003620
PPM1D	hsa-let-7f-1-3p	90.6259	NM_003620
PPM1D	hsa-let-7b-3p	90.6259	NM_003620
PPM1D	hsa-miR-548f-3p	90.0526	NM_003620
PPM1D	hsa-miR-548bc	90.0526	NM_003620
PPM1D	hsa-miR-548e-3p	90.0526	NM_003620
PPM1D	hsa-miR-548a-3p	90.0526	NM_003620
PPM1D	hsa-miR-548az-3p	90.0526	NM_003620
PPM1D	hsa-miR-205-3p	89.5544	NM_003620
PPM1D	hsa-miR-6807-3p	89.4725	NM_003620
PPM1D	hsa-miR-4699-3p	89.075	NM_003620
PPM1D	hsa-miR-1468-3p	88.6116	NM_003620
PPM1D	hsa-miR-548g-3p	88.2592	NM_003620
PPM1D	hsa-miR-4687-5p	88.152	NM_003620
PPM1D	hsa-miR-3911	87.669	NM_003620
PPM1D	hsa-miR-1283	87.5354	NM_003620
PPM1D	hsa-miR-147a	84.9239	NM_003620
PPM1D	hsa-miR-5187-5p	84.3652	NM_003620
PPM1D	hsa-miR-155-5p	84.2145	NM_003620
PPM1D	hsa-miR-3065-3p	83.7399	NM_003620
PPM1D	hsa-miR-606	83.24	NM_003620
PPM1D	hsa-miR-5688	83.1613	NM_003620
PPM1D	hsa-miR-495-3p	83.1613	NM_003620
PPM1D	hsa-miR-4499	82.8882	NM_003620
PPM1D	hsa-miR-616-5p	82.6013	NM_003620
PPM1D	hsa-miR-153-3p	82.1734	NM_003620
PPM1D	hsa-miR-203b-3p	81.7908	NM_003620
PPM1D	hsa-miR-33a-3p	81.5296	NM_003620
PPM1D	hsa-miR-767-5p	80.6984	NM_003620
PPM1D	hsa-miR-4425	80.679	NM_003620
PPM1D	hsa-miR-10527-5p	80.6455	NM_003620
PPM1D	hsa-miR-373-5p	80.6275	NM_003620
PPM1D	hsa-miR-371b-5p	80.6275	NM_003620

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Motifs and transcription factors (TFs) regulating PPM1D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPM1D	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PPM1D	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPM1D	transfac_pro__M07397	ZNF148 (directAnnotation).
PPM1D	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PPM1D	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PPM1D	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PPM1D	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PPM1D	metacluster_7.13	ZFX (directAnnotation).
PPM1D	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PPM1D	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PPM1D	transfac_pro__M01175	ZBTB7B (directAnnotation).
PPM1D	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPM1D	tfdimers__MD00151	CHURC1 (directAnnotation).
PPM1D	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PPM1D	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PPM1D	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPM1D	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PPM1D	transfac_pro__M02090	E2F4 (directAnnotation).
PPM1D	transfac_pro__M01714	KLF15 (directAnnotation).
PPM1D	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PPM1D	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPM1D	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PPM1D	transfac_pro__M02089	E2F3 (directAnnotation).
PPM1D	metacluster_3.14	WT1; WT1 (directAnnotation).
PPM1D	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PPM1D	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PPM1D	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PPM1D	cisbp__M07938	E2F1 (directAnnotation).
PPM1D	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PPM1D	transfac_pro__M07436	WT1 (directAnnotation).
PPM1D	transfac_pro__M02281	SP1 (directAnnotation).
PPM1D	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PPM1D	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPM1D	transfac_pro__M02898	SMAD3 (directAnnotation).
PPM1D	transfac_public__M00491	PATZ1 (directAnnotation).
PPM1D	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."