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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPIP5K2

Summary for PPIP5K2

Gene information	Gene symbol	PPIP5K2
	Ensembl ID	ENSG00000145725
	Entrez ID	23262
	Gene name	diphosphoinositol pentakisphosphate kinase 2
	Synonyms	CFAP160\|DFNB100\|HISPPD1\|KIAA0433\|VIP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPIP5K2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.434807	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.270398	3.37e-30

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Expression of PPIP5K2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPIP5K2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPIP5K2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPIP5K2	hsa-miR-4262	98.92	NM_001276277
PPIP5K2	hsa-miR-181b-5p	98.6866	NM_001276277
PPIP5K2	hsa-miR-181c-5p	98.6866	NM_001276277
PPIP5K2	hsa-miR-181a-5p	98.6866	NM_001276277
PPIP5K2	hsa-miR-181d-5p	98.6866	NM_001276277
PPIP5K2	hsa-miR-3978	97.8522	NM_001276277
PPIP5K2	hsa-miR-1277-5p	95.7183	NM_015216
PPIP5K2	hsa-miR-103a-3p	95.6021	NM_001276277
PPIP5K2	hsa-miR-107	95.6021	NM_001276277
PPIP5K2	hsa-miR-380-3p	94.5875	NM_015216
PPIP5K2	hsa-miR-582-5p	93.9046	NM_015216
PPIP5K2	hsa-miR-498-5p	93.8412	NM_001276277
PPIP5K2	hsa-miR-548n	93.618	NM_015216
PPIP5K2	hsa-miR-12136	93.5587	NM_015216
PPIP5K2	hsa-miR-3688-3p	93.5014	NM_015216
PPIP5K2	hsa-miR-1299	92.226	NM_015216
PPIP5K2	hsa-miR-3153	92.0448	NM_015216
PPIP5K2	hsa-miR-4766-3p	92.014	NM_001276277
PPIP5K2	hsa-miR-6733-5p	91.8976	NM_015216
PPIP5K2	hsa-miR-6739-5p	91.8976	NM_015216
PPIP5K2	hsa-miR-448	91.6917	NM_015216
PPIP5K2	hsa-miR-337-3p	91.6621	NM_001276277
PPIP5K2	hsa-miR-4436b-5p	89.6291	NM_015216
PPIP5K2	hsa-miR-5047	87.9193	NM_001276277
PPIP5K2	hsa-miR-1301-3p	87.9193	NM_001276277
PPIP5K2	hsa-miR-1283	87.9012	NM_015216
PPIP5K2	hsa-miR-508-5p	87.7789	NM_001276277
PPIP5K2	hsa-miR-5688	87.7623	NM_015216
PPIP5K2	hsa-miR-12124	85.7474	NM_015216
PPIP5K2	hsa-miR-495-3p	85.0553	NM_015216
PPIP5K2	hsa-miR-5093	84.5797	NM_015216
PPIP5K2	hsa-miR-7156-3p	83.0426	NM_001276277
PPIP5K2	hsa-miR-1276	82.7387	NM_015216
PPIP5K2	hsa-miR-8485	82.5594	NM_015216
PPIP5K2	hsa-miR-4729	82.4838	NM_015216
PPIP5K2	hsa-miR-10522-5p	81.7151	NM_015216
PPIP5K2	hsa-miR-498-3p	80.0338	NM_001276277

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Motifs and transcription factors (TFs) regulating PPIP5K2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPIP5K2	hdpi__ETV4	ETV4 (directAnnotation).
PPIP5K2	hdpi__TP73	TP73 (directAnnotation).
PPIP5K2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PPIP5K2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PPIP5K2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PPIP5K2	transfac_pro__M04862	NRF1 (directAnnotation).
PPIP5K2	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."