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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPIF

Summary for PPIF

Gene information	Gene symbol	PPIF
	Ensembl ID	ENSG00000108179
	Entrez ID	10105
	Gene name	peptidylprolyl isomerase F
	Synonyms	Cyp-D\|CypD\|hCyP3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPIF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.646058	7.24e-05
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.361146	1.85e-16
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.566935	5.67e-19
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.52187	5.03e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.34882	3.83e-16
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.391949	5.67e-26
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.614182	2.77e-42
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.610621	1.40e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.420399	4.00e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.33243	5.25e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.1023	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.404811	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.662678	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.686168	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.717775	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.408937	5.42e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.333847	9.83e-25

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Expression of PPIF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPIF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPIF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPIF	hsa-miR-23b-3p	98.4284	NM_005729
PPIF	hsa-miR-23a-3p	98.4284	NM_005729
PPIF	hsa-miR-23c	98.4284	NM_005729
PPIF	hsa-miR-4269	89.9213	NM_005729
PPIF	hsa-miR-124-3p	88.5454	NM_005729
PPIF	hsa-miR-1281	87.7795	NM_005729
PPIF	hsa-miR-4733-5p	86.6494	NM_005729
PPIF	hsa-miR-6779-3p	86.2522	NM_005729
PPIF	hsa-miR-506-3p	86.0524	NM_005729
PPIF	hsa-miR-6715b-5p	85.3337	NM_005729
PPIF	hsa-miR-126-5p	85.0703	NM_005729
PPIF	hsa-miR-5582-5p	83.8665	NM_005729
PPIF	hsa-miR-7976	81.9267	NM_005729
PPIF	hsa-miR-4795-3p	80.3984	NM_005729
PPIF	hsa-miR-10394-5p	80.2532	NM_005729
PPIF	hsa-miR-1205	80.2532	NM_005729
PPIF	hsa-miR-27b-3p	80.1717	NM_005729
PPIF	hsa-miR-9985	80.1717	NM_005729
PPIF	hsa-miR-27a-3p	80.1717	NM_005729

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Motifs and transcription factors (TFs) regulating PPIF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPIF	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PPIF	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPIF	metacluster_22.37	BACH1 (directAnnotation).
PPIF	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PPIF	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PPIF	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
PPIF	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PPIF	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
PPIF	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
PPIF	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PPIF	transfac_pro__M05981	ZNF233 (directAnnotation).
PPIF	transfac_pro__M01239	RELA (directAnnotation).
PPIF	metacluster_167.7	IRF8 (inferredBy_Orthology).
PPIF	cisbp__M02748	NFATC1 (directAnnotation).
PPIF	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
PPIF	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
PPIF	tfdimers__MD00409	ETS1; YY2 (directAnnotation).
PPIF	transfac_pro__M06375	ZNF629 (inferredBy_Orthology).
PPIF	metacluster_172.27	DMRTC2 (directAnnotation).
PPIF	swissregulon__hs__SOX14	SOX14 (directAnnotation).
PPIF	transfac_pro__M05542	SNAPC4 (directAnnotation).
PPIF	metacluster_22.19	NFE2 (directAnnotation).
PPIF	metacluster_22.13	MAFK (inferredBy_Orthology).
PPIF	kznf__ZNF547_Imbeault2017_OM_MEME	ZNF547 (directAnnotation).
PPIF	transfac_pro__M05612	ZNF189 (directAnnotation).
PPIF	transfac_public__M00208	NFKB1; RELA (directAnnotation).
PPIF	taipale_tf_pairs__ALX4_TBX21_RGGTGYTAATWR_CAP	ALX4; TBX21 (directAnnotation).
PPIF	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
PPIF	metacluster_22.29	NFE2 (directAnnotation).
PPIF	metacluster_22.17	NFE2 (directAnnotation).
PPIF	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
PPIF	kznf__ZNF792_Imbeault2017_RP_ChIP-seq	ZNF792 (directAnnotation).
PPIF	tfdimers__MD00208	IRF1; LTF (directAnnotation).
PPIF	metacluster_22.25	NFE2L2 (directAnnotation).
PPIF	transfac_pro__M06985	BATF3 (directAnnotation).
PPIF	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
PPIF	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
PPIF	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
PPIF	jaspar__MA1951.1	FOS (directAnnotation).
PPIF	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
PPIF	taipale_tf_pairs__MEIS1_DRGX_TGTCAATTA_CAP_repr	DRGX; MEIS1 (directAnnotation).
PPIF	tfdimers__MD00411	ELF5; YY1 (directAnnotation).
PPIF	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
PPIF	transfac_pro__M06012	ZNF586 (directAnnotation).
PPIF	metacluster_187.8	ZNF22 (directAnnotation).
PPIF	tfdimers__MD00521	CHURC1; TAF6; TBP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPIF	"Coumarin 120"	DB08168	small molecule
PPIF	"Cyclosporine"	DB00091	small molecule
PPIF	"Proline"	DB00172	small molecule
PPIF	"Triglyme"	DB02078	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."