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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPBP

Summary for PPBP

Gene information	Gene symbol	PPBP
	Ensembl ID	ENSG00000163736
	Entrez ID	5473
	Gene name	pro-platelet basic protein
	Synonyms	b-TG1\|Beta-TG\|CTAP3\|CTAPIII\|CXCL7\|LA-PF4\|LDGF\|MDGF\|NAP-2\|NAP-2-L1\|PBP\|SCYB7\|TGB\|TGB1\|THBGB1
	Gene type	protein_coding
	UniProtAcc	P02775

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Dataset with differentially expressed gene: PPBP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	-1.40078	3.37e-04
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	-0.730878	3.85e-05
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	-0.816077	2.92e-37
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.74432	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	0.505803	3.85e-16
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	CD8+ T cells	0.558362	6.58e-09
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	NK cells	0.739276	3.30e-09
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	CD4+ T cells	1.45234	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Erythrocytes	1.04564	2.55e-02

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Expression of PPBP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPBP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPBP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPBP	hsa-miR-5009-3p	93.5978	NM_002704
PPBP	hsa-miR-3140-5p	91.2452	NM_002704
PPBP	hsa-miR-629-5p	87.9571	NM_002704
PPBP	hsa-miR-4524a-3p	87.7277	NM_002704
PPBP	hsa-miR-3152-3p	87.3155	NM_002704
PPBP	hsa-miR-4795-3p	85.0755	NM_002704
PPBP	hsa-miR-6783-3p	84.1188	NM_002704
PPBP	hsa-miR-146a-5p	83.6731	NM_002704
PPBP	hsa-miR-146b-5p	83.6731	NM_002704
PPBP	hsa-miR-7153-5p	83.6731	NM_002704
PPBP	hsa-miR-3668	83.541	NM_002704
PPBP	hsa-miR-320a-5p	82.4686	NM_002704
PPBP	hsa-miR-1267	82.3905	NM_002704
PPBP	hsa-miR-1343-3p	82.2846	NM_002704

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Motifs and transcription factors (TFs) regulating PPBP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPBP	metacluster_22.34	BACH2 (directAnnotation).
PPBP	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
PPBP	transfac_pro__M01267	FOSL1 (directAnnotation).
PPBP	transfac_pro__M03870	FOSL2 (directAnnotation).
PPBP	metacluster_22.1	MAFF (inferredBy_Orthology).
PPBP	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
PPBP	metacluster_22.28	BACH1 (directAnnotation).
PPBP	metacluster_22.30	NFE2L2 (directAnnotation).
PPBP	metacluster_22.25	NFE2L2 (directAnnotation).
PPBP	metacluster_29.1	STAT4; STAT5A; STAT5A; STAT5B (directAnnotation). STAT5B; STAT5B (inferredBy_Orthology).
PPBP	transfac_pro__M05592	FIZ1 (directAnnotation).
PPBP	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).
PPBP	transfac_pro__M06830	ZNF528 (directAnnotation).
PPBP	jaspar__MA0136.3	ELF5 (inferredBy_Orthology).
PPBP	taipale_tf_pairs__TEAD4_FLI1_RCCGGAAATRSY_CAP	FLI1; TEAD4 (directAnnotation).
PPBP	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
PPBP	metacluster_12.2	MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFG; MAFG; MAFG; MAFK; MAFK; MAFK; MAFK; NRL; NRL; NRL; NRL; NRL (directAnnotation). MAF; MAF; MAFA; MAFA; MAFB; MAFB; MAFB; MAFB; MAFF; MAFF; MAFG; MAFG; MAFK; MAFK; NRL; NRL (inferredBy_Orthology).
PPBP	transfac_pro__M00326	PAX1 (directAnnotation).
PPBP	transfac_pro__M05972	ZNF701 (directAnnotation).
PPBP	metacluster_85.10	ZNF585B; ZNF586 (directAnnotation).
PPBP	jaspar__MA1935.1	FOXI1 (directAnnotation).
PPBP	tfdimers__MD00392	E2F1; NKX2-1 (directAnnotation).
PPBP	tfdimers__MD00581	ATF5; NKX3-2 (directAnnotation).
PPBP	transfac_pro__M05952	ZNF672 (inferredBy_Orthology).
PPBP	metacluster_30.2	MAF; MAF; MAFA; MAFB; MAFF; MAFF; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; MAFG; MAFG; MAFG; MAFG; MAFK; MAFK; MAFK; MAFK; MAFK; MAFK; MAFK; ZNF547; ZNF547 (directAnnotation). MAF; MAF; MAFA; MAFA; MAFA; MAFB; MAFB; MAFB; MAFB; MAFB; MAFF; MAFF; MAFF; MAFG; MAFG; MAFK; MAFK; MAFK; MAFK; MAFK; MAFK; NRL; NRL (inferredBy_Orthology).
PPBP	hocomoco__SPDEF_HUMAN.H11MO.0.D	SPDEF (directAnnotation).
PPBP	transfac_pro__M05627	ZNF320 (directAnnotation).
PPBP	metacluster_79.34	GATA2; GATA5 (directAnnotation).
PPBP	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
PPBP	transfac_pro__M05317	SOX30 (directAnnotation).
PPBP	taipale_tf_pairs__CEBPG_ELF1_TTGCGYAANNSCGGAAGN_CAP_repr	CEBPG; ELF1 (directAnnotation).
PPBP	metacluster_155.17	PRDM14; ZNF264 (directAnnotation). PRDM14 (inferredBy_Orthology).
PPBP	kznf__ZNF443_Imbeault2017_RP_RCADE	ZNF443 (directAnnotation).
PPBP	transfac_pro__M06692	PRDM10 (directAnnotation).
PPBP	swissregulon__mm__Zbtb12	ZBTB12 (inferredBy_Orthology).
PPBP	tfdimers__MD00349	GABPA; YY2 (directAnnotation).
PPBP	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
PPBP	swissregulon__mm__Mafg	MAFG (inferredBy_Orthology).
PPBP	transfac_pro__M06869	ZNF600 (directAnnotation).
PPBP	transfac_pro__M06093	ZNF17 (directAnnotation).
PPBP	transfac_pro__M06025	ZNF195 (directAnnotation).
PPBP	taipale_tf_pairs__TEAD4_FOXI1_RCATWCCNNNNNNNNNNNNRTMAACA_CAP_repr	FOXI1; TEAD4 (directAnnotation).
PPBP	transfac_pro__M02095	FOSL1 (directAnnotation).
PPBP	transfac_pro__M06009	ZNF175 (directAnnotation).
PPBP	transfac_pro__M06550	ZNF519 (directAnnotation).
PPBP	transfac_pro__M06613	ZNF514 (directAnnotation).
PPBP	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
PPBP	metacluster_137.5	FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; JUN; JUNB; JUNB; JUND; JUND (directAnnotation). JUN (inferredBy_Orthology).
PPBP	transfac_pro__M02269	FEV (directAnnotation).
PPBP	transfac_pro__M06603	ZNF560 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPBP	"Copper"	DB09130	small molecule
PPBP	"Ethanesulfonic acid"	DB03635	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."