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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPAT

Summary for PPAT

Gene information	Gene symbol	PPAT
	Ensembl ID	ENSG00000128059
	Entrez ID	5471
	Gene name	phosphoribosyl pyrophosphate amidotransferase
	Synonyms	GPAT\|PRAT
	Gene type	protein_coding
	UniProtAcc	Q06203

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Dataset with differentially expressed gene: PPAT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.25151	4.74e-22

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Expression of PPAT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPAT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPAT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPAT	hsa-miR-4422	97.5394	NM_002703
PPAT	hsa-miR-4795-3p	96.4849	NM_002703
PPAT	hsa-miR-548c-3p	95.8134	NM_002703
PPAT	hsa-miR-466	93.1236	NM_002703
PPAT	hsa-miR-371b-5p	92.0787	NM_002703
PPAT	hsa-miR-3611	91.5714	NM_002703
PPAT	hsa-miR-4753-5p	91.2105	NM_002703
PPAT	hsa-miR-548aj-3p	89.3512	NM_002703
PPAT	hsa-miR-548x-3p	89.3512	NM_002703
PPAT	hsa-miR-4719	88.8798	NM_002703
PPAT	hsa-miR-4534	88.2934	NM_002703
PPAT	hsa-miR-616-5p	88.2003	NM_002703
PPAT	hsa-miR-373-5p	88.2003	NM_002703
PPAT	hsa-miR-545-5p	87.97	NM_002703
PPAT	hsa-miR-548j-3p	87.9539	NM_002703
PPAT	hsa-miR-548am-3p	87.9539	NM_002703
PPAT	hsa-miR-548ae-3p	87.9539	NM_002703
PPAT	hsa-miR-548aq-3p	87.9539	NM_002703
PPAT	hsa-miR-548ah-3p	87.9539	NM_002703
PPAT	hsa-miR-335-3p	87.7125	NM_002703
PPAT	hsa-miR-4531	86.9688	NM_002703
PPAT	hsa-miR-4789-3p	86.6736	NM_002703
PPAT	hsa-miR-8082	86.1045	NM_002703
PPAT	hsa-miR-5692b	86.088	NM_002703
PPAT	hsa-miR-5692c	86.088	NM_002703
PPAT	hsa-miR-4319	85.9569	NM_002703
PPAT	hsa-miR-6835-3p	85.4052	NM_002703
PPAT	hsa-miR-216a-5p	85.3064	NM_002703
PPAT	hsa-miR-6818-5p	85.306	NM_002703
PPAT	hsa-miR-125a-5p	84.7748	NM_002703
PPAT	hsa-miR-125b-5p	84.7748	NM_002703
PPAT	hsa-miR-5582-3p	84.3789	NM_002703
PPAT	hsa-miR-670-5p	84.1838	NM_002703
PPAT	hsa-miR-372-5p	84.0158	NM_002703
PPAT	hsa-miR-5093	82.9622	NM_002703
PPAT	hsa-miR-12136	82.936	NM_002703
PPAT	hsa-miR-371a-5p	81.2712	NM_002703
PPAT	hsa-miR-4756-3p	81.1907	NM_002703
PPAT	hsa-miR-17-3p	80.5074	NM_002703
PPAT	hsa-miR-1323	80.2026	NM_002703

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Motifs and transcription factors (TFs) regulating PPAT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPAT	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PPAT	transfac_pro__M04748	GABPA (directAnnotation).
PPAT	jaspar__MA0776.1	MYBL1 (directAnnotation).
PPAT	transfac_pro__M04950	EGR1 (directAnnotation).
PPAT	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPAT	"Dasatinib"	DB01254	small molecule
PPAT	"L-Glutamine"	DB00130	small molecule
PPAT	"Mercaptopurine"	DB01033	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."