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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPARG

Summary for PPARG

Gene information	Gene symbol	PPARG
	Ensembl ID	ENSG00000132170
	Entrez ID	5468
	Gene name	peroxisome proliferator activated receptor gamma
	Synonyms	NR1C3\|PPARG1\|PPARG2\|PPARgamma
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPARG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.419838	6.72e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.476073	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.307035	1.16e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.329468	1.68e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.478752	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	3.54617	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.285065	0.00e+00

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Expression of PPARG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPARG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PPARG	Epigenetic Alteration of DNA, RNA or Protein
PPARG	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PPARG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPARG	hsa-miR-548n	95.4807	NM_005037
PPARG	hsa-miR-548o-5p	95.3504	NM_005037
PPARG	hsa-miR-548j-5p	95.3504	NM_005037
PPARG	hsa-miR-548i	95.3504	NM_005037
PPARG	hsa-miR-559	95.3504	NM_005037
PPARG	hsa-miR-548ab	95.3504	NM_005037
PPARG	hsa-miR-548am-5p	95.3504	NM_005037
PPARG	hsa-miR-548ay-5p	95.3504	NM_005037
PPARG	hsa-miR-548ae-5p	95.3504	NM_005037
PPARG	hsa-miR-548au-5p	95.3504	NM_005037
PPARG	hsa-miR-548ap-5p	95.3504	NM_005037
PPARG	hsa-miR-548a-5p	95.3504	NM_005037
PPARG	hsa-miR-548d-5p	95.3504	NM_005037
PPARG	hsa-miR-548w	95.3504	NM_005037
PPARG	hsa-miR-548c-5p	95.3504	NM_005037
PPARG	hsa-miR-548ak	95.3504	NM_005037
PPARG	hsa-miR-548ad-5p	95.3504	NM_005037
PPARG	hsa-miR-548h-5p	95.3504	NM_005037
PPARG	hsa-miR-548b-5p	95.3504	NM_005037
PPARG	hsa-miR-548as-5p	95.3504	NM_005037
PPARG	hsa-miR-548aq-5p	95.3504	NM_005037
PPARG	hsa-miR-548ar-5p	95.3504	NM_005037
PPARG	hsa-miR-548bb-5p	95.3504	NM_005037
PPARG	hsa-miR-548y	95.3504	NM_005037
PPARG	hsa-miR-513a-3p	94.4125	NM_005037
PPARG	hsa-miR-513c-3p	94.4125	NM_005037
PPARG	hsa-miR-3606-3p	93.9775	NM_005037
PPARG	hsa-miR-9985	93.5199	NM_005037
PPARG	hsa-miR-27a-3p	93.5199	NM_005037
PPARG	hsa-miR-27b-3p	93.5199	NM_005037
PPARG	hsa-miR-3617-3p	93.33	NM_005037
PPARG	hsa-miR-5694	92.2404	NM_005037
PPARG	hsa-miR-454-3p	90.9803	NM_005037
PPARG	hsa-miR-10397-3p	90.4531	NM_005037
PPARG	hsa-miR-301a-3p	89.6827	NM_005037
PPARG	hsa-miR-301b-3p	89.6827	NM_005037
PPARG	hsa-miR-4295	89.6827	NM_005037
PPARG	hsa-miR-130a-3p	89.6827	NM_005037
PPARG	hsa-miR-3666	89.6827	NM_005037
PPARG	hsa-miR-130b-3p	89.6827	NM_005037
PPARG	hsa-miR-4446-5p	89.3639	NM_005037
PPARG	hsa-miR-586	88.7249	NM_005037
PPARG	hsa-miR-548az-5p	87.3849	NM_005037
PPARG	hsa-miR-548t-5p	87.3849	NM_005037
PPARG	hsa-miR-4671-3p	87.3389	NM_005037
PPARG	hsa-miR-3154	82.9384	NM_005037
PPARG	hsa-miR-889-3p	81.5517	NM_005037
PPARG	hsa-miR-7515	80.7542	NM_005037

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Motifs and transcription factors (TFs) regulating PPARG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPARG	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PPARG	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PPARG	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PPARG	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PPARG	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PPARG	hdpi__ETV4	ETV4 (directAnnotation).
PPARG	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
PPARG	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
PPARG	cisbp__M02645	ETS1 (directAnnotation).
PPARG	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
PPARG	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PPARG	transfac_pro__M06156	ZNF75D (directAnnotation).
PPARG	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PPARG	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
PPARG	jaspar__MA1483.2	ELF2 (directAnnotation).
PPARG	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
PPARG	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PPARG	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
PPARG	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PPARG	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
PPARG	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
PPARG	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
PPARG	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
PPARG	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PPARG	jaspar__MA1957.1	ELK1 (directAnnotation).
PPARG	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PPARG	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PPARG	transfac_pro__M04950	EGR1 (directAnnotation).
PPARG	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PPARG	transfac_pro__M04826	EP300 (directAnnotation).
PPARG	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PPARG	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PPARG	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PPARG	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PPARG	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PPARG	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPARG	transfac_pro__M00652	NRF1 (directAnnotation).
PPARG	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PPARG	transfac_pro__M04866	HDAC2 (directAnnotation).
PPARG	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPARG	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PPARG	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PPARG	jaspar__MA1708.1	ETV7 (directAnnotation).
PPARG	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
PPARG	hdpi__ELF2	ELF2 (directAnnotation).
PPARG	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PPARG	metacluster_183.4	ETS1 (inferredBy_Orthology).
PPARG	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PPARG	jaspar__MA1932.1	HOXB13 (directAnnotation).
PPARG	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPARG	"(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid"	DB08760	small molecule
PPARG	"(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid"	DB07842	small molecule
PPARG	"(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid"	DB08121	small molecule
PPARG	"(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID"	DB07675	small molecule
PPARG	"(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC AC	DB06908	small molecule
PPARG	"(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid"	DB07111	small molecule
PPARG	"(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid"	DB08435	small molecule
PPARG	"(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid"	DB07172	small molecule
PPARG	"(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid"	DB07208	small molecule
PPARG	"(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid"	DB07209	small molecule
PPARG	"(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid"	DB06926	small molecule
PPARG	"(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid"	DB04270	small molecule
PPARG	"2-chloro-5-nitro-N-phenylbenzamide"	DB07863	small molecule
PPARG	"2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID"	DB08402	small molecule
PPARG	"2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID"	DB04689	small molecule
PPARG	"2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID"	DB07053	small molecule
PPARG	"3-(5-methoxy-1H-indol-3-yl)propanoic acid"	DB07723	small molecule
PPARG	"3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE"	DB08560	small molecule
PPARG	"3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid"	DB08302	small molecule
PPARG	"9(S)-HODE"	DB07302	small molecule
PPARG	"Aleglitazar"	DB08915	small molecule
PPARG	"alpha-Linolenic acid"	DB00132	small molecule
PPARG	"AMG-131"	DB05490	small molecule
PPARG	"Amiodarone"	DB01118	small molecule
PPARG	"Arhalofenate"	DB11811	small molecule
PPARG	"Balsalazide"	DB01014	small molecule
PPARG	"Bezafibrate"	DB01393	small molecule
PPARG	"Cannabidiol"	DB09061	small molecule
PPARG	"Capric acid"	DB03600	small molecule
PPARG	"Ciglitazone"	DB09201	small molecule
PPARG	"Clinofibrate"	DB09006	small molecule
PPARG	"Clofazimine"	DB00845	small molecule
PPARG	"CLX-0921"	DB05854	small molecule
PPARG	"Curcumin sulfate"	DB14635	small molecule
PPARG	"Curcumin"	DB11672	small molecule
PPARG	"Darglitazone"	DB14034	small molecule
PPARG	"Dexibuprofen"	DB09213	small molecule
PPARG	"difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron"	DB07509	small molecule
PPARG	"Doconexent"	DB03756	small molecule
PPARG	"Elafibranor"	DB05187	small molecule
PPARG	"Ertiprotafib"	DB06521	small molecule
PPARG	"Fenofibric acid"	DB13873	small molecule
PPARG	"Fenoprofen"	DB00573	small molecule
PPARG	"Fish oil"	DB13961	biotech
PPARG	"Flufenamic acid"	DB02266	small molecule
PPARG	"Glipizide"	DB01067	small molecule
PPARG	"Ibuprofen"	DB01050	small molecule
PPARG	"Icosapent"	DB00159	small molecule
PPARG	"Indeglitazar"	DB07724	small molecule
PPARG	"Indomethacin"	DB00328	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."