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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPARA

Summary for PPARA

Gene information	Gene symbol	PPARA
	Ensembl ID	ENSG00000186951
	Entrez ID	5465
	Gene name	peroxisome proliferator activated receptor alpha
	Synonyms	hPPAR\|NR1C1\|PPAR
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPARA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Fibroblasts	-0.462526	2.97e-02

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Expression of PPARA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPARA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPARA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPARA	hsa-miR-6867-5p	98.0324	NM_001001928
PPARA	hsa-miR-512-3p	95.3177	NM_001001928
PPARA	hsa-miR-506-5p	94.4381	NM_001001928
PPARA	hsa-miR-506-3p	92.8941	NM_001001928
PPARA	hsa-miR-124-3p	92.8941	NM_001001928
PPARA	hsa-miR-6817-5p	89.4145	NM_001001928
PPARA	hsa-miR-4769-3p	89.4145	NM_001001928
PPARA	hsa-miR-19a-3p	89.2645	NM_001001928
PPARA	hsa-miR-19b-3p	89.2645	NM_001001928
PPARA	hsa-miR-2113	89.0809	NM_001001928
PPARA	hsa-miR-548ap-3p	89.0785	NM_001001928
PPARA	hsa-miR-548t-3p	89.0785	NM_001001928
PPARA	hsa-miR-548aa	89.0785	NM_001001928
PPARA	hsa-miR-548az-5p	88.5018	NM_001001928
PPARA	hsa-miR-548t-5p	88.5018	NM_001001928
PPARA	hsa-miR-4261	88.4719	NM_001001928
PPARA	hsa-miR-302e	86.8021	NM_001001928
PPARA	hsa-miR-6738-3p	86.3729	NM_001001928
PPARA	hsa-miR-141-3p	86.1449	NM_001001928
PPARA	hsa-miR-200a-3p	86.1449	NM_001001928
PPARA	hsa-miR-9-5p	85.4883	NM_001001928
PPARA	hsa-miR-665	84.913	NM_001001928
PPARA	hsa-miR-3165	84.6731	NM_001001928
PPARA	hsa-miR-302b-3p	84.2655	NM_001001928
PPARA	hsa-miR-302a-3p	84.2655	NM_001001928
PPARA	hsa-miR-9986	84.1451	NM_001001928
PPARA	hsa-miR-1294	84.1451	NM_001001928
PPARA	hsa-miR-7160-5p	83.002	NM_001001928
PPARA	hsa-miR-93-5p	82.7791	NM_001001928
PPARA	hsa-miR-585-5p	82.7515	NM_001001928
PPARA	hsa-miR-147b-5p	82.6371	NM_001001928
PPARA	hsa-miR-4262	81.7208	NM_001001928
PPARA	hsa-miR-520a-5p	81.7078	NM_001001928
PPARA	hsa-miR-525-5p	81.7078	NM_001001928
PPARA	hsa-miR-4731-5p	81.528	NM_001001928
PPARA	hsa-miR-590-3p	81.1386	NM_001001928
PPARA	hsa-miR-202-3p	80.644	NM_001001928
PPARA	hsa-miR-520b-3p	80.5089	NM_001001928
PPARA	hsa-miR-302d-3p	80.5089	NM_001001928
PPARA	hsa-miR-520c-3p	80.5089	NM_001001928
PPARA	hsa-miR-372-3p	80.5089	NM_001001928
PPARA	hsa-miR-520e-3p	80.5089	NM_001001928
PPARA	hsa-miR-302c-3p	80.5089	NM_001001928
PPARA	hsa-miR-520a-3p	80.5089	NM_001001928
PPARA	hsa-miR-520d-3p	80.5089	NM_001001928
PPARA	hsa-miR-373-3p	80.4588	NM_001001928

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Motifs and transcription factors (TFs) regulating PPARA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPARA	dbtfbs__ZBED5_HepG2_ENCSR656SIB_merged_N1	ZBED5 (directAnnotation).
PPARA	metacluster_134.5	ZNF184 (directAnnotation).
PPARA	transfac_pro__M06027	ZNF891 (directAnnotation).
PPARA	metacluster_198.3	ZFP64 (directAnnotation).
PPARA	kznf__ZNF786_Imbeault2017_RP_ChIP-seq	ZNF786 (directAnnotation).
PPARA	metacluster_143.13	ZBTB7A (directAnnotation).
PPARA	jaspar__MA1534.1	NR1I3 (directAnnotation).
PPARA	metacluster_67.1	ZFP64 (directAnnotation).
PPARA	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
PPARA	transfac_pro__M05479	ZNF580 (directAnnotation).
PPARA	metacluster_135.11	NR2C2 (directAnnotation).
PPARA	dbtfbs__HIC1_HEK293_ENCSR803GYT_merged_N1	HIC1 (directAnnotation).
PPARA	metacluster_182.5	HINFP (directAnnotation).
PPARA	taipale_tf_pairs__TFAP4_DLX3_NCAGSTGNNNNNNNGTAATKR_CAP_repr	DLX3; TFAP4 (directAnnotation).
PPARA	jaspar__MA0131.2	HINFP (directAnnotation).
PPARA	transfac_pro__M07387	ZBTB7A (directAnnotation).
PPARA	transfac_pro__M06880	ZFP82 (inferredBy_Orthology).
PPARA	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PPARA	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PPARA	taipale_tf_pairs__ETV2_PAX5_ACCGGANNTACGCNNNNNYR_CAP	ETV2; PAX5 (directAnnotation).
PPARA	kznf__ZNF124_Imbeault2017_OM_RCADE	ZNF124 (directAnnotation).
PPARA	taipale_tf_pairs__ETV2_SOX15_RSCGGAWNNNNNNNACAATRN_CAP_repr	ETV2; SOX15 (directAnnotation).
PPARA	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PPARA	metacluster_172.3	SMAD7 (directAnnotation). SMAD7 (inferredBy_Orthology).
PPARA	transfac_pro__M06516	ZNF418 (directAnnotation).
PPARA	transfac_pro__M01303	SP1 (directAnnotation).
PPARA	metacluster_3.14	WT1; WT1 (directAnnotation).
PPARA	transfac_pro__M00986	CHURC1 (directAnnotation).
PPARA	transfac_pro__M01152	NR1I2; RXRA (directAnnotation).
PPARA	taipale_tf_pairs__TEAD4_MAX_RCATTCCNNNNNNNCACGTG_CAP_repr	MAX; TEAD4 (directAnnotation).
PPARA	taipale_tf_pairs__HOXB2_HOXB13_NNMATCACATAAAN_CAP_repr	HOXB13; HOXB2 (directAnnotation).
PPARA	transfac_pro__M06950	HIF3A (inferredBy_Orthology).
PPARA	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PPARA	transfac_pro__M01253	CNOT3 (directAnnotation).
PPARA	transfac_pro__M04817	ZBTB33 (directAnnotation).
PPARA	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PPARA	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PPARA	tfdimers__MD00148	CHURC1; ZBTB7A (directAnnotation).
PPARA	taipale_cyt_meth__NR1I3_NYGAACTWW_FL_meth_repr	NR1I3 (directAnnotation).
PPARA	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PPARA	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PPARA	transfac_pro__M07436	WT1 (directAnnotation).
PPARA	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PPARA	transfac_pro__M01122	ZNF219 (directAnnotation).
PPARA	transfac_pro__M04595	SALL2 (directAnnotation).
PPARA	transfac_pro__M06435	ZNF429 (directAnnotation).
PPARA	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPARA	"Aleglitazar"	DB08915	small molecule
PPARA	"alpha-Linolenic acid"	DB00132	small molecule
PPARA	"Amiodarone"	DB01118	small molecule
PPARA	"Arachidonic Acid"	DB04557	small molecule
PPARA	"Bezafibrate"	DB01393	small molecule
PPARA	"Caprylic acid"	DB04519	small molecule
PPARA	"Cardarine"	DB05416	small molecule
PPARA	"Ciprofibrate"	DB09064	small molecule
PPARA	"Clinofibrate"	DB09006	small molecule
PPARA	"Clofibrate"	DB00636	small molecule
PPARA	"Dexibuprofen"	DB09213	small molecule
PPARA	"Doconexent"	DB03756	small molecule
PPARA	"Elafibranor"	DB05187	small molecule
PPARA	"Ertiprotafib"	DB06521	small molecule
PPARA	"Fenofibrate"	DB01039	small molecule
PPARA	"Fenofibric acid"	DB13873	small molecule
PPARA	"Fenoprofen"	DB00573	small molecule
PPARA	"Fish oil"	DB13961	biotech
PPARA	"Flufenamic acid"	DB02266	small molecule
PPARA	"Gemfibrozil"	DB01241	small molecule
PPARA	"GW-590735"	DB07215	small molecule
PPARA	"Ibuprofen"	DB01050	small molecule
PPARA	"Icosapent"	DB00159	small molecule
PPARA	"Indeglitazar"	DB07724	small molecule
PPARA	"Indomethacin"	DB00328	small molecule
PPARA	"Isoflavone"	DB12007	small molecule
PPARA	"Lauric acid"	DB03017	small molecule
PPARA	"Leukotriene B4"	DB12961	small molecule
PPARA	"Muraglitazar"	DB06510	small molecule
PPARA	"Myristic acid"	DB08231	small molecule
PPARA	"Myrrh"	DB11605	small molecule
PPARA	"N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide"	DB01890	small molecule
PPARA	"Oleic Acid"	DB04224	small molecule
PPARA	"Omega-3 fatty acids"	DB11133	small molecule
PPARA	"Palmitic Acid"	DB03796	small molecule
PPARA	"Phthalic Acid"	DB02746	small molecule
PPARA	"Prasterone"	DB01708	small molecule
PPARA	"Ragaglitazar"	DB06533	small molecule
PPARA	"Reglitazar"	DB04971	small molecule
PPARA	"Resveratrol"	DB02709	small molecule
PPARA	"Rosiglitazone"	DB00412	small molecule
PPARA	"Soybean oil"	DB09422	biotech
PPARA	"Stearic acid"	DB03193	small molecule
PPARA	"Tesaglitazar"	DB06536	small molecule
PPARA	"Troglitazone"	DB00197	small molecule
PPARA	"Valproic acid"	DB00313	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."