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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POU2AF1

Summary for POU2AF1

Gene information	Gene symbol	POU2AF1
	Ensembl ID	ENSG00000110777
	Entrez ID	5450
	Gene name	POU class 2 homeobox associating factor 1
	Synonyms	BOB1\|OBF1\|OCA-B
	Gene type	protein_coding
	UniProtAcc	Q16633

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Dataset with differentially expressed gene: POU2AF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.299433	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.402138	9.03e-06
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.545566	1.40e-45
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.260602	0.00e+00

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Expression of POU2AF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POU2AF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POU2AF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POU2AF1	hsa-miR-4533	100	NM_006235
POU2AF1	hsa-miR-6876-5p	100	NM_006235
POU2AF1	hsa-miR-4476	100	NM_006235
POU2AF1	hsa-miR-1252-5p	99.9995	NM_006235
POU2AF1	hsa-miR-5196-5p	99.3982	NM_006235
POU2AF1	hsa-miR-4747-5p	98.8087	NM_006235
POU2AF1	hsa-miR-1321	98.5999	NM_006235
POU2AF1	hsa-miR-4756-5p	98.4696	NM_006235
POU2AF1	hsa-miR-4739	98.4696	NM_006235
POU2AF1	hsa-miR-6785-5p	97.9309	NM_006235
POU2AF1	hsa-miR-6883-5p	97.9309	NM_006235
POU2AF1	hsa-miR-4728-5p	97.9309	NM_006235
POU2AF1	hsa-miR-149-3p	97.9309	NM_006235
POU2AF1	hsa-miR-3154	97.3855	NM_006235
POU2AF1	hsa-miR-7106-5p	97.0933	NM_006235
POU2AF1	hsa-miR-766-5p	95.9924	NM_006235
POU2AF1	hsa-miR-6127	92.8592	NM_006235
POU2AF1	hsa-miR-6129	91.6085	NM_006235
POU2AF1	hsa-miR-6130	91.6085	NM_006235
POU2AF1	hsa-miR-4510	91.6085	NM_006235
POU2AF1	hsa-miR-6133	91.6085	NM_006235
POU2AF1	hsa-miR-1249-5p	89.0988	NM_006235
POU2AF1	hsa-miR-6797-5p	89.0988	NM_006235
POU2AF1	hsa-miR-548aa	88.4854	NM_006235
POU2AF1	hsa-miR-548ap-3p	88.4854	NM_006235
POU2AF1	hsa-miR-548t-3p	88.4854	NM_006235
POU2AF1	hsa-miR-7977	86.1726	NM_006235
POU2AF1	hsa-miR-766-3p	84.2419	NM_006235
POU2AF1	hsa-miR-542-3p	83.6145	NM_006235
POU2AF1	hsa-miR-4779	83.5259	NM_006235
POU2AF1	hsa-miR-9902	83.4336	NM_006235
POU2AF1	hsa-miR-6505-3p	81.1352	NM_006235
POU2AF1	hsa-miR-6758-5p	80.9624	NM_006235
POU2AF1	hsa-miR-3978	80.0327	NM_006235

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Motifs and transcription factors (TFs) regulating POU2AF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POU2AF1	metacluster_22.29	NFE2 (directAnnotation).
POU2AF1	tfdimers__MD00208	IRF1; LTF (directAnnotation).
POU2AF1	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
POU2AF1	metacluster_141.4	GLIS2 (directAnnotation).
POU2AF1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
POU2AF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
POU2AF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
POU2AF1	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."