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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POM121

Summary for POM121

Gene information	Gene symbol	POM121
	Ensembl ID	ENSG00000196313
	Entrez ID	9883
	Gene name	POM121 transmembrane nucleoporin
	Synonyms	DKFZP586G1822\|DKFZP586P2220\|KIAA0618\|POM121A
	Gene type	protein_coding
	UniProtAcc	Q96HA1

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Dataset with differentially expressed gene: POM121

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.260371	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.528752	0.00e+00

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Expression of POM121 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POM121

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POM121

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POM121	hsa-miR-1252-5p	96.0018	NM_172020
POM121	hsa-miR-150-5p	94.4316	NM_172020
POM121	hsa-miR-4713-5p	92.6345	NM_172020
POM121	hsa-miR-499b-3p	92.2087	NM_172020
POM121	hsa-miR-499a-3p	92.2087	NM_172020
POM121	hsa-miR-4755-3p	91.7436	NM_001257190
POM121	hsa-miR-23a-3p	91.4728	NM_172020
POM121	hsa-miR-23b-3p	91.4728	NM_172020
POM121	hsa-miR-23c	91.4728	NM_172020
POM121	hsa-miR-4260	88.8564	NM_001257190
POM121	hsa-miR-32-3p	88.7784	NM_172020
POM121	hsa-miR-4446-5p	87.8997	NM_001257190
POM121	hsa-miR-6776-3p	87.1931	NM_172020
POM121	hsa-miR-1909-5p	86.8557	NM_001257190
POM121	hsa-miR-765	86.7833	NM_001257190
POM121	hsa-miR-5579-3p	86.2457	NM_172020
POM121	hsa-miR-3163	85.8111	NM_172020
POM121	hsa-miR-4668-5p	85.3352	NM_172020
POM121	hsa-miR-11181-3p	85.2808	NM_001257190
POM121	hsa-miR-4722-5p	85.1279	NM_172020
POM121	hsa-miR-451b	85.1212	NM_172020
POM121	hsa-miR-6829-5p	85.0687	NM_172020
POM121	hsa-miR-6845-5p	84.8636	NM_172020
POM121	hsa-miR-132-3p	84.0385	NM_172020
POM121	hsa-miR-494-3p	84.006	NM_172020
POM121	hsa-miR-4691-5p	83.6518	NM_172020
POM121	hsa-miR-6792-3p	83.6518	NM_172020
POM121	hsa-miR-384	83.6	NM_172020
POM121	hsa-miR-1913	82.9159	NM_001257190
POM121	hsa-miR-6811-5p	82.3316	NM_001257190
POM121	hsa-miR-6511b-5p	82.3316	NM_001257190
POM121	hsa-miR-450a-1-3p	82.1761	NM_172020
POM121	hsa-miR-1297	82.0715	NM_172020
POM121	hsa-miR-629-3p	81.8154	NM_172020
POM121	hsa-miR-9500	81.5451	NM_001257190
POM121	hsa-miR-18a-3p	81.4856	NM_001257190
POM121	hsa-miR-6887-5p	81.2955	NM_172020
POM121	hsa-miR-6795-5p	81.2955	NM_172020
POM121	hsa-miR-218-2-3p	81.1602	NM_172020
POM121	hsa-miR-1227-5p	81.041	NM_172020
POM121	hsa-miR-10394-5p	80.6943	NM_001257190
POM121	hsa-miR-1205	80.6943	NM_001257190
POM121	hsa-miR-4755-5p	80.4214	NM_001257190
POM121	hsa-miR-5006-3p	80.4214	NM_001257190
POM121	hsa-miR-6762-5p	80.3523	NM_172020

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Motifs and transcription factors (TFs) regulating POM121

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POM121	metacluster_7.13	ZFX (directAnnotation).
POM121	cisbp__M01863	ZNF711 (inferredBy_Orthology).
POM121	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
POM121	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
POM121	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
POM121	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
POM121	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
POM121	transfac_pro__M04826	EP300 (directAnnotation).
POM121	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
POM121	transfac_pro__M04950	EGR1 (directAnnotation).
POM121	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
POM121	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
POM121	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
POM121	transfac_pro__M00652	NRF1 (directAnnotation).
POM121	transfac_pro__M04866	HDAC2 (directAnnotation).
POM121	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
POM121	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."