Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POLR3G

Summary for POLR3G

Gene information	Gene symbol	POLR3G
	Ensembl ID	ENSG00000113356
	Entrez ID	10622
	Gene name	RNA polymerase III subunit G
	Synonyms	C31\|RPC32\|RPC7
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: POLR3G

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.381983	3.81e-20
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.485281	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.502954	9.41e-29
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.508742	3.41e-39
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.390114	1.53e-16

Top

Expression of POLR3G in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to POLR3G

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating POLR3G

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POLR3G	hsa-miR-1297	99.5623	NM_006467
POLR3G	hsa-miR-26b-5p	99.2579	NM_006467
POLR3G	hsa-miR-26a-5p	99.2579	NM_006467
POLR3G	hsa-miR-4465	98.8984	NM_006467
POLR3G	hsa-miR-2115-3p	96.6796	NM_006467
POLR3G	hsa-miR-548ai	95.4726	NM_006467
POLR3G	hsa-miR-548ag	95.4726	NM_006467
POLR3G	hsa-miR-548ba	95.4726	NM_006467
POLR3G	hsa-miR-570-5p	95.4726	NM_006467
POLR3G	hsa-miR-3163	94.2001	NM_006467
POLR3G	hsa-miR-3156-5p	92.9101	NM_006467
POLR3G	hsa-miR-633	92.8668	NM_006467
POLR3G	hsa-miR-4760-3p	92.5548	NM_006467
POLR3G	hsa-miR-548m	92.0944	NM_006467
POLR3G	hsa-miR-548l	90.6529	NM_006467
POLR3G	hsa-miR-196a-1-3p	89.8343	NM_006467
POLR3G	hsa-miR-6844	89.3703	NM_006467
POLR3G	hsa-miR-1200	88.0724	NM_006467
POLR3G	hsa-miR-6802-3p	87.8296	NM_006467
POLR3G	hsa-miR-4324	87.7376	NM_006467
POLR3G	hsa-miR-4423-3p	87.6753	NM_006467
POLR3G	hsa-miR-3184-3p	87.0746	NM_006467
POLR3G	hsa-miR-7-1-3p	87.0546	NM_006467
POLR3G	hsa-miR-7-2-3p	87.0546	NM_006467
POLR3G	hsa-miR-376c-3p	86.7537	NM_006467
POLR3G	hsa-miR-549a-3p	86.6498	NM_006467
POLR3G	hsa-miR-9-5p	86.227	NM_006467
POLR3G	hsa-miR-124-3p	85.1052	NM_006467
POLR3G	hsa-miR-4446-5p	84.5157	NM_006467
POLR3G	hsa-miR-944	84.2798	NM_006467
POLR3G	hsa-miR-5582-5p	83.6878	NM_006467
POLR3G	hsa-miR-511-3p	83.2995	NM_006467
POLR3G	hsa-miR-338-5p	83.2989	NM_006467
POLR3G	hsa-miR-20a-5p	83.1364	NM_006467
POLR3G	hsa-miR-106b-5p	83.1364	NM_006467
POLR3G	hsa-miR-93-5p	82.7233	NM_006467
POLR3G	hsa-miR-544a	82.7171	NM_006467
POLR3G	hsa-miR-4282	82.3584	NM_006467
POLR3G	hsa-miR-144-3p	82.3482	NM_006467
POLR3G	hsa-miR-12124	82.2543	NM_006467
POLR3G	hsa-miR-506-3p	81.7194	NM_006467
POLR3G	hsa-miR-4495	81.3185	NM_006467

Page: 1

Top

Motifs and transcription factors (TFs) regulating POLR3G

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POLR3G	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
POLR3G	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
POLR3G	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
POLR3G	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
POLR3G	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."