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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POLR3E

Summary for POLR3E

Gene information	Gene symbol	POLR3E
	Ensembl ID	ENSG00000284282
	Entrez ID	55718
	Gene name	RNA polymerase III subunit E
	Synonyms	C37\|FLJ10509\|RPC5\|SIN
	Gene type	protein_coding
	UniProtAcc	Q9NVU0

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Dataset with differentially expressed gene: POLR3E

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.322469	0.00e+00

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Expression of POLR3E in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POLR3E

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POLR3E

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POLR3E	hsa-miR-30d-5p	99.1944	NM_001258033
POLR3E	hsa-miR-30a-5p	99.1944	NM_001258033
POLR3E	hsa-miR-30e-5p	99.1944	NM_001258033
POLR3E	hsa-miR-30b-5p	98.8951	NM_001258033
POLR3E	hsa-miR-30c-5p	98.8951	NM_001258033
POLR3E	hsa-miR-3613-5p	97.381	NM_001258033
POLR3E	hsa-miR-610	91.7679	NM_018119
POLR3E	hsa-miR-9983-3p	91.6564	NM_001258033
POLR3E	hsa-miR-10527-5p	90.3944	NM_018119
POLR3E	hsa-miR-129-5p	88.6224	NM_001258033
POLR3E	hsa-let-7c-3p	88.501	NM_018119
POLR3E	hsa-miR-6516-3p	87.3358	NM_001258033
POLR3E	hsa-miR-6759-3p	87.2752	NM_018119
POLR3E	hsa-miR-4641	86.0695	NM_018119
POLR3E	hsa-miR-544a	85.3644	NM_001258033
POLR3E	hsa-miR-5002-5p	84.2242	NM_001258033
POLR3E	hsa-miR-520h	83.4354	NM_018119
POLR3E	hsa-miR-520g-3p	83.4354	NM_018119
POLR3E	hsa-miR-221-3p	83.152	NM_018119
POLR3E	hsa-miR-222-3p	83.152	NM_018119
POLR3E	hsa-miR-6740-3p	81.8666	NM_001258033
POLR3E	hsa-miR-9898	81.6952	NM_001258033
POLR3E	hsa-miR-29c-3p	81.4055	NM_001258033
POLR3E	hsa-miR-29a-3p	81.4055	NM_001258033
POLR3E	hsa-miR-29b-3p	81.4055	NM_001258033
POLR3E	hsa-miR-3915	80.523	NM_018119

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Motifs and transcription factors (TFs) regulating POLR3E

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POLR3E	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
POLR3E	jaspar__MA0748.2	YY2 (directAnnotation).
POLR3E	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
POLR3E	cisbp__M00788	ZFY (inferredBy_Orthology).
POLR3E	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
POLR3E	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
POLR3E	transfac_pro__M01199	TRIM28 (directAnnotation).
POLR3E	metacluster_7.13	ZFX (directAnnotation).
POLR3E	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
POLR3E	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
POLR3E	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
POLR3E	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
POLR3E	cisbp__M00968	MTF2 (directAnnotation).
POLR3E	transfac_pro__M04916	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."