Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | 0.383882 | 1.30e-28 |
GSE131984_Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | NA | Malignant cells | 0.339229 | 1.28e-18 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.300037 | 8.61e-20 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | post | Malignant cells | -0.555416 | 2.63e-31 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | NK cells | -0.271778 | 2.70e-02 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | -1.07095 | 0.00e+00 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.397141 | 1.66e-33 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.410835 | 3.92e-22 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.456428 | 9.19e-37 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.337869 | 1.69e-14 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | 0.277136 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.868807 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 0.277355 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | 0.58443 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
POLR2K | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
POLR2K | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
POLR2K | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
POLR2K | taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr | ELF1; MEIS1 (directAnnotation). |
POLR2K | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
POLR2K | taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP | ETV5; HOXA2 (directAnnotation). |
POLR2K | hdpi__ETV4 | ETV4 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP | ETV5; FOXI1 (directAnnotation). |
POLR2K | cisbp__M02645 | ETS1 (directAnnotation). |
POLR2K | taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP | ELK3; FOXO1 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP | EOMES; ETV5 (directAnnotation). |
POLR2K | metacluster_166.2 | ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology). |
POLR2K | taipale_tf_pairs__ETV2_TCF3_CASSTGNNCCGGAWRYN_CAP_repr | ETV2; TCF3 (directAnnotation). |
POLR2K | taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP | ELK3; HOXB2 (directAnnotation). |
POLR2K | cisbp__M00808 | MYPOP (inferredBy_Orthology). |
POLR2K | taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP | ELK1; EOMES (directAnnotation). |
POLR2K | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
POLR2K | taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr | ERF; FOXI1 (directAnnotation). |
POLR2K | taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP | ELK1; FOXI1 (directAnnotation). |
POLR2K | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
POLR2K | dbtfbs__E2F8_representative_N1 | E2F8 (directAnnotation). |
POLR2K | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
POLR2K | taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr | ELK1; EOMES (directAnnotation). |
POLR2K | hdpi__TP73 | TP73 (directAnnotation). |
POLR2K | taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP | ETV4; FOXO1 (directAnnotation). |
POLR2K | transfac_pro__M04862 | NRF1 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP | ETV2; FOXO6 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP | ETV2; FOXI1 (directAnnotation). |
POLR2K | taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP | FLI1; FOXI1 (directAnnotation). |
POLR2K | jaspar__MA1708.1 | ETV7 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP | ETV2; SPDEF (directAnnotation). |
POLR2K | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
POLR2K | transfac_pro__M05548 | PLAGL2 (directAnnotation). |
POLR2K | jaspar__MA1932.1 | HOXB13 (directAnnotation). |
POLR2K | taipale_tf_pairs__HOXD12_TBX21_AGGTGTKAAGTCGTAAA_CAP_repr | HOXD12; TBX21 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV2_ONECUT2_RCCGGAANNNNNNATCGATN_CAP_repr | ETV2; ONECUT2 (directAnnotation). |
POLR2K | taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP | ETV5; EVX1 (directAnnotation). |
POLR2K | taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr | ELK1; TBX21 (directAnnotation). |
POLR2K | hdpi__ELF2 | ELF2 (directAnnotation). |
POLR2K | swissregulon__hs__ELK1 | ELK1 (directAnnotation). |
POLR2K | metacluster_81.7 | CREB1 (directAnnotation). |
POLR2K | transfac_pro__M04848 | TAF1 (directAnnotation). |
POLR2K | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
POLR2K | transfac_pro__M06249 | ZNF616 (directAnnotation). |
POLR2K | metacluster_15.4 | SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology). |
POLR2K | jaspar__MA1933.1 | SREBF2 (directAnnotation). |
POLR2K | taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr | ELK1; HOXA3 (directAnnotation). |
POLR2K | taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr | EOMES; MYBL1 (directAnnotation). |
POLR2K | transfac_pro__M05711 | ZNF37A (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |