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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POLR2D

Summary for POLR2D

Gene information	Gene symbol	POLR2D
	Ensembl ID	ENSG00000144231
	Entrez ID	5433
	Gene name	RNA polymerase II subunit D
	Synonyms	RPB4
	Gene type	protein_coding
	UniProtAcc	O15514

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Dataset with differentially expressed gene: POLR2D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.866293	1.45e-04
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.315298	2.74e-14
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.259433	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.332662	1.62e-25
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.609471	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.29924	7.31e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.261696	1.98e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.293609	0.00e+00

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Expression of POLR2D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POLR2D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POLR2D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POLR2D	hsa-miR-6829-5p	93.0542	NM_004805
POLR2D	hsa-miR-6780a-5p	92.7254	NM_004805
POLR2D	hsa-miR-1273h-5p	92.222	NM_004805
POLR2D	hsa-miR-6779-5p	90.1035	NM_004805
POLR2D	hsa-miR-3689a-3p	90.1035	NM_004805
POLR2D	hsa-miR-30b-3p	90.1035	NM_004805
POLR2D	hsa-miR-3689b-3p	90.1035	NM_004805
POLR2D	hsa-miR-3689c	90.1035	NM_004805
POLR2D	hsa-miR-548ax	90.0639	NM_004805
POLR2D	hsa-miR-548ao-5p	90.0639	NM_004805
POLR2D	hsa-miR-6771-3p	88.0703	NM_004805
POLR2D	hsa-miR-3658	85.3784	NM_004805
POLR2D	hsa-miR-515-5p	85.0284	NM_004805
POLR2D	hsa-miR-519e-5p	85.0284	NM_004805
POLR2D	hsa-miR-548c-3p	84.0962	NM_004805
POLR2D	hsa-miR-4741	83.7174	NM_004805
POLR2D	hsa-miR-4675	83.7174	NM_004805
POLR2D	hsa-miR-4477a	81.8319	NM_004805
POLR2D	hsa-miR-3663-5p	81.2054	NM_004805
POLR2D	hsa-miR-3620-3p	80.531	NM_004805

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Motifs and transcription factors (TFs) regulating POLR2D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POLR2D	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
POLR2D	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
POLR2D	jaspar__MA1933.1	SREBF2 (directAnnotation).
POLR2D	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."