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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POLR1F

Summary for POLR1F

Gene information	Gene symbol	POLR1F
	Ensembl ID	ENSG00000105849
	Entrez ID	221830
	Gene name	RNA polymerase I subunit F
	Synonyms	A43\|RPA43\|TWISTNB
	Gene type	protein_coding
	UniProtAcc	Q3B726

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Dataset with differentially expressed gene: POLR1F

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.306879	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.263145	0.00e+00

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Expression of POLR1F in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POLR1F

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POLR1F

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POLR1F	hsa-miR-625-3p	93.5869	NM_001002926
POLR1F	hsa-miR-645	88.7574	NM_001002926
POLR1F	hsa-miR-1231	88.2566	NM_001002926
POLR1F	hsa-miR-581	86.909	NM_001002926
POLR1F	hsa-miR-12123	86.8428	NM_001002926
POLR1F	hsa-miR-374a-3p	86.6354	NM_001002926
POLR1F	hsa-miR-431-5p	86.4469	NM_001002926
POLR1F	hsa-miR-182-5p	86.3772	NM_001002926
POLR1F	hsa-miR-651-3p	85.0697	NM_001002926
POLR1F	hsa-miR-5692a	84.8228	NM_001002926
POLR1F	hsa-miR-10527-5p	83.6024	NM_001002926
POLR1F	hsa-miR-10522-5p	82.8711	NM_001002926
POLR1F	hsa-miR-584-5p	82.8287	NM_001002926
POLR1F	hsa-miR-1208	82.1808	NM_001002926
POLR1F	hsa-let-7a-3p	82.172	NM_001002926
POLR1F	hsa-miR-98-3p	82.172	NM_001002926
POLR1F	hsa-let-7b-3p	82.172	NM_001002926
POLR1F	hsa-let-7f-1-3p	82.172	NM_001002926
POLR1F	hsa-miR-568	82.0521	NM_001002926
POLR1F	hsa-miR-2052	81.8757	NM_001002926
POLR1F	hsa-miR-3119	81.6544	NM_001002926
POLR1F	hsa-miR-4652-3p	81.2615	NM_001002926
POLR1F	hsa-miR-548e-5p	80.574	NM_001002926
POLR1F	hsa-miR-8485	80.0242	NM_001002926

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Motifs and transcription factors (TFs) regulating POLR1F

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."