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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POLH

Summary for POLH

Gene information	Gene symbol	POLH
	Ensembl ID	ENSG00000170734
	Entrez ID	5429
	Gene name	DNA polymerase eta
	Synonyms	RAD30A\|XP-V
	Gene type	protein_coding
	UniProtAcc	Q9Y253

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Dataset with differentially expressed gene: POLH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of POLH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POLH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POLH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POLH	hsa-miR-6778-3p	99.7391	NM_001291969
POLH	hsa-miR-6738-3p	97.1738	NM_001291970
POLH	hsa-miR-577	96.5203	NM_001291969
POLH	hsa-miR-5001-3p	96.455	NM_001291970
POLH	hsa-miR-616-5p	95.9912	NM_001291969
POLH	hsa-miR-371b-5p	95.9912	NM_001291969
POLH	hsa-miR-373-5p	95.9912	NM_001291969
POLH	hsa-miR-3686	95.8909	NM_001291969
POLH	hsa-miR-4278	95.2845	NM_001291969
POLH	hsa-miR-1297	95.0844	NM_001291969
POLH	hsa-miR-12136	94.3674	NM_001291969
POLH	hsa-miR-4772-3p	92.952	NM_001291970
POLH	hsa-miR-4728-5p	92.9052	NM_001291969
POLH	hsa-miR-7151-3p	92.782	NM_001291969
POLH	hsa-miR-619-5p	92.5385	NM_001291969
POLH	hsa-miR-544a	91.6214	NM_001291970
POLH	hsa-miR-6801-5p	91.4035	NM_001291969
POLH	hsa-miR-10393-3p	91.4035	NM_001291969
POLH	hsa-miR-6785-5p	90.6512	NM_001291969
POLH	hsa-miR-6514-3p	87.4984	NM_001291969
POLH	hsa-let-7a-2-3p	87.152	NM_001291969
POLH	hsa-let-7g-3p	87.152	NM_001291969
POLH	hsa-miR-26b-5p	86.8438	NM_001291969
POLH	hsa-miR-26a-5p	86.8438	NM_001291969
POLH	hsa-miR-4308	86.1972	NM_001291970
POLH	hsa-miR-149-3p	86.0421	NM_001291969
POLH	hsa-miR-6883-5p	86.0421	NM_001291969
POLH	hsa-miR-10522-5p	84.475	NM_001291970
POLH	hsa-miR-504-3p	83.3633	NM_001291969
POLH	hsa-miR-150-5p	83.2325	NM_001291969
POLH	hsa-miR-548aw	82.9246	NM_001291970
POLH	hsa-miR-4465	82.5929	NM_001291969
POLH	hsa-miR-3163	82.4124	NM_001291969
POLH	hsa-miR-10b-5p	82.3267	NM_001291969
POLH	hsa-miR-10a-5p	82.3267	NM_001291969
POLH	hsa-miR-6124	81.3022	NM_001291969
POLH	hsa-miR-6079	81.1891	NM_001291970
POLH	hsa-miR-9983-3p	81.0286	NM_001291969
POLH	hsa-miR-6071	80.364	NM_001291970
POLH	hsa-miR-6811-3p	80.1631	NM_001291969
POLH	hsa-miR-3662	80.0869	NM_001291970

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Motifs and transcription factors (TFs) regulating POLH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POLH	transfac_pro__M05523	ZBTB46 (directAnnotation).
POLH	swissregulon__hs__MYB	MYB (directAnnotation).
POLH	taipale_tf_pairs__ETV2_RFX5_NACTTCCGGYNNNNGCAACSN_CAP_repr	ETV2; RFX5 (directAnnotation).
POLH	transfac_pro__M04944	GABPA (directAnnotation).
POLH	nitta__sens_TATGCT40NACT_KAA_AATAAATCACTGCA_m1_c3	GFI1 (inferredBy_Orthology).
POLH	transfac_pro__M06340	ZNF790 (directAnnotation).
POLH	tfdimers__MD00388	LEF1; NKX3-2; TCF7; TCF7L1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."