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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: POGK

Summary for POGK

Gene information	Gene symbol	POGK
	Ensembl ID	ENSG00000143157
	Entrez ID	57645
	Gene name	pogo transposable element derived with KRAB domain
	Synonyms	BASS2\|KIAA15131\|KRBOX2\|LST003
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: POGK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.355541	1.19e-25
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.292607	8.35e-16

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Expression of POGK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to POGK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating POGK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
POGK	hsa-miR-1250-3p	96.7852	NM_001314014
POGK	hsa-miR-491-5p	96.2037	NM_001314014
POGK	hsa-miR-3671	95.8809	NM_001314014
POGK	hsa-miR-515-5p	95.0753	NM_001314014
POGK	hsa-miR-3125	93.58	NM_001314014
POGK	hsa-miR-3916	93.58	NM_001314014
POGK	hsa-miR-6859-5p	93.58	NM_001314014
POGK	hsa-miR-613	93.2268	NM_001314014
POGK	hsa-miR-519e-5p	92.9227	NM_001314014
POGK	hsa-miR-1-3p	92.7565	NM_001314014
POGK	hsa-miR-206	92.7565	NM_001314014
POGK	hsa-miR-511-5p	92.4943	NM_001314014
POGK	hsa-miR-593-3p	91.2598	NM_001314014
POGK	hsa-miR-22-3p	89.1835	NM_001314014
POGK	hsa-miR-627-3p	87.1513	NM_001314014
POGK	hsa-miR-6882-3p	86.6157	NM_001314014
POGK	hsa-miR-4534	86.3824	NM_001314014
POGK	hsa-miR-6079	85.2613	NM_001314014
POGK	hsa-miR-539-5p	84.7108	NM_001314014
POGK	hsa-miR-607	84.3675	NM_001314014
POGK	hsa-miR-562	83.6147	NM_001314014
POGK	hsa-miR-6869-5p	83.2859	NM_001314014
POGK	hsa-miR-1825	83.064	NM_001314014
POGK	hsa-miR-8075	83.0418	NM_001314014
POGK	hsa-miR-519d-5p	82.162	NM_001314014
POGK	hsa-miR-6716-5p	81.026	NM_001314014
POGK	hsa-miR-101-3p	80.0367	NM_001314014

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Motifs and transcription factors (TFs) regulating POGK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
POGK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
POGK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
POGK	metacluster_7.13	ZFX (directAnnotation).
POGK	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
POGK	cisbp__M00968	MTF2 (directAnnotation).
POGK	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
POGK	metacluster_160.20	JUND; PRDM15 (directAnnotation).
POGK	cisbp__M00341	PAX6 (directAnnotation).
POGK	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
POGK	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
POGK	cisbp__M00788	ZFY (inferredBy_Orthology).
POGK	metacluster_175.1	ZNF283 (directAnnotation).
POGK	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
POGK	transfac_pro__M01199	TRIM28 (directAnnotation).
POGK	metacluster_151.2	ZNF23 (directAnnotation).
POGK	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
POGK	transfac_pro__M03806	ZBTB7C (directAnnotation).
POGK	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
POGK	metacluster_131.6	EGR2; EGR4 (directAnnotation). EGR2; EGR3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."