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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PMS1

Summary for PMS1

Gene information	Gene symbol	PMS1
	Ensembl ID	ENSG00000064933
	Entrez ID	5378
	Gene name	PMS1 homolog 1, mismatch repair system component
	Synonyms	MLH2\|PMSL1
	Gene type	protein_coding
	UniProtAcc	P54277

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Dataset with differentially expressed gene: PMS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.337322	3.27e-23

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Expression of PMS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PMS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PMS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PMS1	hsa-miR-3163	98.761	NM_001321049
PMS1	hsa-miR-4778-3p	96.4052	NM_001321049
PMS1	hsa-miR-4799-5p	95.2365	NM_001321049
PMS1	hsa-miR-4738-3p	95.2317	NM_001321049
PMS1	hsa-miR-3973	93.9268	NM_001321049
PMS1	hsa-miR-944	93.8498	NM_001321049
PMS1	hsa-miR-4307	93.3285	NM_001321049
PMS1	hsa-miR-3658	92.7572	NM_001321049
PMS1	hsa-miR-3664-3p	89.4991	NM_001321049
PMS1	hsa-miR-1303	89.3327	NM_001321051
PMS1	hsa-miR-95-5p	89.2212	NM_001321049
PMS1	hsa-miR-126-5p	88.8809	NM_001321051
PMS1	hsa-miR-140-3p	86.5645	NM_001321049
PMS1	hsa-miR-548ar-3p	85.1015	NM_001321049
PMS1	hsa-miR-6888-5p	84.6718	NM_001321051
PMS1	hsa-miR-4478	84.2652	NM_001321049
PMS1	hsa-miR-3977	84.2094	NM_001321049
PMS1	hsa-miR-2681-5p	84.2094	NM_001321049
PMS1	hsa-miR-524-5p	84.1289	NM_000534
PMS1	hsa-miR-520d-5p	84.1289	NM_000534
PMS1	hsa-miR-3908	83.6056	NM_001321049
PMS1	hsa-miR-642b-3p	83.3072	NM_000534
PMS1	hsa-miR-642a-3p	83.3072	NM_000534
PMS1	hsa-miR-548az-3p	82.9472	NM_001321049
PMS1	hsa-miR-548a-3p	82.9472	NM_001321049
PMS1	hsa-miR-548e-3p	82.9472	NM_001321049
PMS1	hsa-miR-548f-3p	82.9472	NM_001321049
PMS1	hsa-miR-548bc	82.9472	NM_001321049
PMS1	hsa-miR-548av-3p	82.2162	NM_001321049
PMS1	hsa-miR-6834-5p	81.7153	NM_001321049
PMS1	hsa-miR-4284	81.0387	NM_001321051
PMS1	hsa-miR-548d-3p	80.7959	NM_001321049
PMS1	hsa-miR-548h-3p	80.7959	NM_001321049
PMS1	hsa-miR-548z	80.7959	NM_001321049
PMS1	hsa-miR-548ac	80.7959	NM_001321049
PMS1	hsa-miR-548bb-3p	80.7959	NM_001321049
PMS1	hsa-miR-7-2-3p	80.4808	NM_001321049
PMS1	hsa-miR-7-1-3p	80.4808	NM_001321049

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Motifs and transcription factors (TFs) regulating PMS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PMS1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PMS1	cisbp__M02645	ETS1 (directAnnotation).
PMS1	hdpi__ETV4	ETV4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."