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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PMEPA1

Summary for PMEPA1

Gene information	Gene symbol	PMEPA1
	Ensembl ID	ENSG00000124225
	Entrez ID	56937
	Gene name	prostate transmembrane protein, androgen induced 1
	Synonyms	STAG1\|TMEPAI
	Gene type	protein_coding
	UniProtAcc	Q969W9

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Dataset with differentially expressed gene: PMEPA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.41756	1.22e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.937052	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.549358	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	0.259636	9.81e-38
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.347663	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.672347	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.509878	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.648582	4.18e-25
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.859672	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.986581	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-1.00043	0.00e+00

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Expression of PMEPA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PMEPA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PMEPA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PMEPA1	hsa-miR-190a-3p	99.9481	NM_001255976
PMEPA1	hsa-miR-5011-5p	99.9382	NM_001255976
PMEPA1	hsa-miR-19a-3p	98.0285	NM_001255976
PMEPA1	hsa-miR-19b-3p	98.0285	NM_001255976
PMEPA1	hsa-miR-877-3p	96.9105	NM_199169
PMEPA1	hsa-miR-6809-3p	96.2055	NM_199169
PMEPA1	hsa-miR-2113	95.7529	NM_001255976
PMEPA1	hsa-miR-4282	95.2876	NM_001255976
PMEPA1	hsa-miR-146a-3p	94.5849	NM_001255976
PMEPA1	hsa-miR-5047	90.652	NM_001255976
PMEPA1	hsa-miR-1301-3p	90.652	NM_001255976
PMEPA1	hsa-miR-548at-5p	90.2872	NM_199169
PMEPA1	hsa-miR-454-3p	89.7759	NM_001255976
PMEPA1	hsa-miR-185-3p	88.493	NM_001255976
PMEPA1	hsa-miR-624-3p	88.3681	NM_001255976
PMEPA1	hsa-miR-4287	88.3089	NM_199169
PMEPA1	hsa-miR-4685-3p	88.3089	NM_199169
PMEPA1	hsa-miR-3065-5p	88.2567	NM_001255976
PMEPA1	hsa-miR-6881-3p	87.9951	NM_199169
PMEPA1	hsa-miR-301b-3p	87.6057	NM_001255976
PMEPA1	hsa-miR-130a-3p	87.6057	NM_001255976
PMEPA1	hsa-miR-301a-3p	87.6057	NM_001255976
PMEPA1	hsa-miR-4295	87.6057	NM_001255976
PMEPA1	hsa-miR-3666	87.6057	NM_001255976
PMEPA1	hsa-miR-130b-3p	87.6057	NM_001255976
PMEPA1	hsa-miR-766-5p	86.7427	NM_001255976
PMEPA1	hsa-miR-6722-3p	86.4172	NM_199169
PMEPA1	hsa-miR-6829-5p	86.2706	NM_001255976
PMEPA1	hsa-miR-6833-3p	85.9301	NM_199169
PMEPA1	hsa-miR-4283	84.0401	NM_001255976
PMEPA1	hsa-miR-1909-3p	83.6876	NM_199169
PMEPA1	hsa-miR-4768-5p	83.5675	NM_199169
PMEPA1	hsa-miR-5000-5p	83.0168	NM_001255976
PMEPA1	hsa-miR-6867-3p	82.9612	NM_001255976
PMEPA1	hsa-miR-3148	82.9276	NM_199169
PMEPA1	hsa-miR-9983-3p	82.3763	NM_001255976
PMEPA1	hsa-miR-585-5p	81.1168	NM_199169
PMEPA1	hsa-miR-4650-5p	81.106	NM_199169
PMEPA1	hsa-miR-4670-3p	81.0104	NM_001255976
PMEPA1	hsa-miR-520g-5p	80.6532	NM_199169
PMEPA1	hsa-miR-5010-3p	80.6239	NM_001255976
PMEPA1	hsa-miR-6810-3p	80.3224	NM_001255976
PMEPA1	hsa-miR-6801-3p	80.3224	NM_001255976

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Motifs and transcription factors (TFs) regulating PMEPA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PMEPA1	transfac_pro__M05628	ZNF735 (directAnnotation).
PMEPA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PMEPA1	transfac_pro__M04826	EP300 (directAnnotation).
PMEPA1	transfac_pro__M04950	EGR1 (directAnnotation).
PMEPA1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PMEPA1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PMEPA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PMEPA1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PMEPA1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PMEPA1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PMEPA1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
PMEPA1	jaspar__MA0502.2	NFYB (directAnnotation).
PMEPA1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PMEPA1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PMEPA1	hdpi__NFIX	NFIX (directAnnotation).
PMEPA1	hdpi__VAX2	VAX2 (directAnnotation).
PMEPA1	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
PMEPA1	swissregulon__hs__SMAD3	SMAD3 (directAnnotation).
PMEPA1	transfac_pro__M06160	ZNF92 (directAnnotation).
PMEPA1	swissregulon__hs__SIX4	SIX4 (directAnnotation).
PMEPA1	transfac_pro__M06490	ZNF664 (directAnnotation).
PMEPA1	transfac_pro__M06609	ZKSCAN4 (directAnnotation).
PMEPA1	hocomoco__MEIS2_HUMAN.H11MO.0.B	MEIS2 (directAnnotation).
PMEPA1	transfac_pro__M05347	NR2C1 (directAnnotation).
PMEPA1	homer__CTGTCTGG_Smad2	SMAD2 (directAnnotation).
PMEPA1	transfac_pro__M04844	MAX (directAnnotation).
PMEPA1	metacluster_84.9	NR2F1 (directAnnotation).
PMEPA1	metacluster_84.8	RARG (inferredBy_Orthology).
PMEPA1	transfac_pro__M03580	SMAD2 (directAnnotation).
PMEPA1	transfac_pro__M05767	ZNF77 (directAnnotation).
PMEPA1	metacluster_84.12	RARB; RARG (directAnnotation).
PMEPA1	metacluster_4.1	SOX10; SOX10; SOX10; SOX21; SOX7; SOX8; SOX9; SRY (directAnnotation).
PMEPA1	transfac_pro__M06762	ZNF222 (directAnnotation).
PMEPA1	transfac_pro__M05329	KLF16 (inferredBy_Orthology).
PMEPA1	transfac_pro__M05399	SCRT2 (inferredBy_Orthology).
PMEPA1	cisbp__M01816	JUN (inferredBy_Orthology).
PMEPA1	taipale_tf_pairs__ETV5_DLX2_RSCGGAANNNNNYAATTA_CAP	DLX2; ETV5 (directAnnotation).
PMEPA1	transfac_public__M00041	ATF2; JUN (directAnnotation).
PMEPA1	transfac_pro__M04814	RELA (directAnnotation).
PMEPA1	transfac_public__M00040	ATF2 (directAnnotation).
PMEPA1	metacluster_153.3	SOX10; SOX10; SOX18; SOX8; SOX8; SOX9; SOX9 (directAnnotation).
PMEPA1	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
PMEPA1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
PMEPA1	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
PMEPA1	taipale_tf_pairs__TEAD4_HOXB13_CYAATAAAATGYN_CAP_repr	HOXB13; TEAD4 (directAnnotation).
PMEPA1	transfac_pro__M06451	ZNF614 (directAnnotation).
PMEPA1	transfac_pro__M05740	ZNF667 (directAnnotation).
PMEPA1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PMEPA1	jaspar__MA1933.1	SREBF2 (directAnnotation).
PMEPA1	swissregulon__hs__ELF2	ELF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."