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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PLXNA1

Summary for PLXNA1

Gene informationGene symbol

PLXNA1

Ensembl ID

ENSG00000114554

Entrez ID

5361

Gene nameplexin A1
SynonymsNOV|PLXN1
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: PLXNA1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4135570.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.2639977.96e-14

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.3161420.00e+00

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Expression of PLXNA1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PLXNA1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLXNA1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PLXNA1hsa-miR-7110-3p98.6572NM_032242
PLXNA1hsa-miR-5011-5p98.2097NM_032242
PLXNA1hsa-miR-4749-3p95.9118NM_032242
PLXNA1hsa-miR-4778-3p95.5199NM_032242
PLXNA1hsa-miR-548p94.9656NM_032242
PLXNA1hsa-miR-6867-5p94.847NM_032242
PLXNA1hsa-miR-190a-3p93.3865NM_032242
PLXNA1hsa-miR-6845-3p92.1923NM_032242
PLXNA1hsa-miR-6873-3p91.8683NM_032242
PLXNA1hsa-miR-1207-5p91.537NM_032242
PLXNA1hsa-miR-4755-3p91.4764NM_032242
PLXNA1hsa-miR-6817-3p91.0569NM_032242
PLXNA1hsa-miR-185-3p90.8126NM_032242
PLXNA1hsa-miR-473990.6193NM_032242
PLXNA1hsa-miR-7-5p88.5517NM_032242
PLXNA1hsa-miR-6887-3p88.4394NM_032242
PLXNA1hsa-miR-449287.7776NM_032242
PLXNA1hsa-miR-449b-3p86.8047NM_032242
PLXNA1hsa-miR-6882-5p86.4421NM_032242
PLXNA1hsa-miR-20a-5p86.3766NM_032242
PLXNA1hsa-miR-106b-5p86.3766NM_032242
PLXNA1hsa-miR-4763-3p86.0347NM_032242
PLXNA1hsa-miR-106a-5p85.5097NM_032242
PLXNA1hsa-miR-20b-5p85.5097NM_032242
PLXNA1hsa-miR-519d-3p85.5097NM_032242
PLXNA1hsa-miR-526b-3p85.5097NM_032242
PLXNA1hsa-miR-93-5p85.5097NM_032242
PLXNA1hsa-miR-17-5p85.5097NM_032242
PLXNA1hsa-miR-4756-5p84.5418NM_032242
PLXNA1hsa-miR-132184.5418NM_032242
PLXNA1hsa-miR-6849-3p83.2678NM_032242
PLXNA1hsa-miR-431983.1962NM_032242
PLXNA1hsa-miR-545-5p81.7697NM_032242
PLXNA1hsa-miR-76281.5246NM_032242
PLXNA1hsa-miR-444181.3195NM_032242
PLXNA1hsa-miR-6813-5p80.9517NM_032242
PLXNA1hsa-miR-216b-5p80.1643NM_032242
PLXNA1hsa-miR-449880.0913NM_032242
PLXNA1hsa-miR-608580.0756NM_032242
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Motifs and transcription factors (TFs) regulating PLXNA1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PLXNA1jaspar__MA1483.2ELF2 (directAnnotation).
PLXNA1transfac_pro__M04950EGR1 (directAnnotation).
PLXNA1transfac_pro__M01253CNOT3 (directAnnotation).
PLXNA1hdpi__NFIXNFIX (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."