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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLXDC2

Summary for PLXDC2

Gene information	Gene symbol	PLXDC2
	Ensembl ID	ENSG00000120594
	Entrez ID	84898
	Gene name	plexin domain containing 2
	Synonyms	FLJ14623\|TEM7R
	Gene type	protein_coding
	UniProtAcc	Q6UX71

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Dataset with differentially expressed gene: PLXDC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.454228	4.68e-12
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.443131	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.487821	4.49e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.444577	1.89e-27
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.344575	3.07e-23
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.664052	0.00e+00

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Expression of PLXDC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLXDC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLXDC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLXDC2	hsa-miR-5011-5p	100	NM_001282736
PLXDC2	hsa-miR-190a-3p	99.9999	NM_001282736
PLXDC2	hsa-miR-6867-5p	99.9996	NM_032812
PLXDC2	hsa-miR-9902	99.5074	NM_001282736
PLXDC2	hsa-miR-2052	99.4206	NM_001282736
PLXDC2	hsa-miR-6783-3p	98.6442	NM_001282736
PLXDC2	hsa-miR-8068	98.5368	NM_032812
PLXDC2	hsa-miR-8485	98.3309	NM_032812
PLXDC2	hsa-miR-1343-3p	98.221	NM_001282736
PLXDC2	hsa-miR-548p	97.4931	NM_001282736
PLXDC2	hsa-miR-7158-3p	97.1571	NM_001282736
PLXDC2	hsa-miR-892c-5p	97.0407	NM_032812
PLXDC2	hsa-miR-4282	96.8792	NM_032812
PLXDC2	hsa-miR-6875-3p	96.841	NM_001282736
PLXDC2	hsa-miR-4422	96.6051	NM_001282736
PLXDC2	hsa-miR-3658	96.5103	NM_001282736
PLXDC2	hsa-miR-590-3p	96.3056	NM_032812
PLXDC2	hsa-miR-4276	95.6362	NM_032812
PLXDC2	hsa-miR-103a-2-5p	94.9867	NM_001282736
PLXDC2	hsa-miR-103a-1-5p	94.5807	NM_001282736
PLXDC2	hsa-miR-6511a-5p	94.527	NM_032812
PLXDC2	hsa-miR-514b-5p	94.4704	NM_032812
PLXDC2	hsa-miR-1278	94.4691	NM_001282736
PLXDC2	hsa-miR-1910-3p	94.2226	NM_032812
PLXDC2	hsa-miR-153-5p	94.0786	NM_032812
PLXDC2	hsa-miR-4775	93.7989	NM_032812
PLXDC2	hsa-miR-4755-5p	93.5896	NM_032812
PLXDC2	hsa-miR-5006-3p	93.5896	NM_032812
PLXDC2	hsa-miR-4446-5p	93.4906	NM_032812
PLXDC2	hsa-miR-3919	93.3579	NM_032812
PLXDC2	hsa-miR-635	93.3302	NM_032812
PLXDC2	hsa-miR-6774-5p	93.3302	NM_032812
PLXDC2	hsa-miR-513c-5p	93.3254	NM_032812
PLXDC2	hsa-miR-4324	93.2417	NM_032812
PLXDC2	hsa-miR-198	93.2292	NM_032812
PLXDC2	hsa-miR-4492	92.7387	NM_032812
PLXDC2	hsa-miR-4498	92.6374	NM_032812
PLXDC2	hsa-miR-4680-3p	92.5008	NM_001282736
PLXDC2	hsa-miR-526b-3p	92.2722	NM_001282736
PLXDC2	hsa-miR-9-3p	91.9878	NM_001282736
PLXDC2	hsa-miR-3152-3p	91.7677	NM_032812
PLXDC2	hsa-miR-4659b-3p	91.7395	NM_001282736
PLXDC2	hsa-miR-4659a-3p	91.7395	NM_001282736
PLXDC2	hsa-miR-10522-5p	91.5568	NM_032812
PLXDC2	hsa-miR-6733-3p	91.3808	NM_032812
PLXDC2	hsa-miR-607	91.3638	NM_032812
PLXDC2	hsa-miR-6885-3p	90.4609	NM_001282736
PLXDC2	hsa-miR-5001-5p	90.3505	NM_032812
PLXDC2	hsa-miR-762	90.3505	NM_032812
PLXDC2	hsa-miR-106b-5p	90.14	NM_001282736

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Motifs and transcription factors (TFs) regulating PLXDC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLXDC2	cisbp__M01815	CEBPE (inferredBy_Orthology).
PLXDC2	metacluster_32.24	ZNF287 (directAnnotation).
PLXDC2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PLXDC2	transfac_pro__M04916	TAF1 (directAnnotation).
PLXDC2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PLXDC2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PLXDC2	transfac_pro__M04887	TCF12 (directAnnotation).
PLXDC2	hocomoco__ZN652_HUMAN.H11MO.0.D	ZNF652 (directAnnotation).
PLXDC2	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
PLXDC2	metacluster_168.4	ZNF652 (directAnnotation).
PLXDC2	tfdimers__MD00515	ARID3A; KLF4 (directAnnotation).
PLXDC2	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
PLXDC2	jaspar__MA0035.4	GATA1 (directAnnotation).
PLXDC2	transfac_pro__M06728	PRDM5 (directAnnotation).
PLXDC2	hdpi__CBFB	CBFB (directAnnotation).
PLXDC2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
PLXDC2	transfac_pro__M03806	ZBTB7C (directAnnotation).
PLXDC2	hdpi__FEZF2	FEZF2 (directAnnotation).
PLXDC2	metacluster_198.3	ZFP64 (directAnnotation).
PLXDC2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PLXDC2	hdpi__NRL	NRL (directAnnotation).
PLXDC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLXDC2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PLXDC2	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
PLXDC2	metacluster_155.11	SPZ1 (directAnnotation).
PLXDC2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PLXDC2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PLXDC2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PLXDC2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PLXDC2	transfac_pro__M04893	TAF1 (directAnnotation).
PLXDC2	transfac_public__M00005	TFAP4 (directAnnotation).
PLXDC2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
PLXDC2	jaspar__MA0131.2	HINFP (directAnnotation).
PLXDC2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLXDC2	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PLXDC2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PLXDC2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."