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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLS1

Summary for PLS1

Gene information	Gene symbol	PLS1
	Ensembl ID	ENSG00000120756
	Entrez ID	5357
	Gene name	plastin 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q14651

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Dataset with differentially expressed gene: PLS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.438498	1.22e-41

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Expression of PLS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLS1	hsa-miR-5692a	97.649	NM_001172312
PLS1	hsa-miR-5011-5p	96.9088	NM_001172312
PLS1	hsa-miR-4698	96.327	NM_001145319
PLS1	hsa-miR-4677-3p	95.9008	NM_001145319
PLS1	hsa-miR-6797-3p	94.6155	NM_001172312
PLS1	hsa-miR-4452	94.1927	NM_001172312
PLS1	hsa-miR-6076	93.852	NM_001172312
PLS1	hsa-miR-8063	93.0446	NM_001145319
PLS1	hsa-miR-4482-3p	92.3459	NM_001172312
PLS1	hsa-miR-5696	90.6341	NM_001172312
PLS1	hsa-miR-1255b-2-3p	89.7571	NM_001172312
PLS1	hsa-miR-4316	88.8994	NM_001172312
PLS1	hsa-miR-4799-5p	88.8646	NM_001145319
PLS1	hsa-miR-32-3p	86.6938	NM_001172312
PLS1	hsa-miR-4503	86.3313	NM_001172312
PLS1	hsa-miR-6839-5p	85.9648	NM_001172312
PLS1	hsa-miR-378j	85.3524	NM_001172312
PLS1	hsa-miR-3674	84.6129	NM_001172312
PLS1	hsa-miR-548g-3p	84.6072	NM_001145319
PLS1	hsa-miR-4661-5p	84.2428	NM_001172312
PLS1	hsa-miR-19b-3p	83.6367	NM_001145319
PLS1	hsa-miR-19a-3p	83.6367	NM_001145319
PLS1	hsa-miR-8055	83.3124	NM_001172312
PLS1	hsa-miR-190a-3p	83.108	NM_001172312
PLS1	hsa-miR-4282	82.8573	NM_001172312
PLS1	hsa-miR-548aw	82.7182	NM_001145319
PLS1	hsa-miR-5689	82.4102	NM_001172312
PLS1	hsa-miR-20a-5p	82.1112	NM_001172312
PLS1	hsa-miR-106b-5p	82.1112	NM_001172312
PLS1	hsa-miR-153-5p	81.6229	NM_001145319
PLS1	hsa-miR-193b-5p	81.1498	NM_001172312

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Motifs and transcription factors (TFs) regulating PLS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLS1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PLS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."