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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLPPR5

Summary for PLPPR5

Gene information	Gene symbol	PLPPR5
	Ensembl ID	ENSG00000117598
	Entrez ID	163404
	Gene name	phospholipid phosphatase related 5
	Synonyms	LPPR5\|PAP2\|PAP2D\|PRG5
	Gene type	protein_coding
	UniProtAcc	Q32ZL2

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Dataset with differentially expressed gene: PLPPR5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.51342	2.01e-05

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Expression of PLPPR5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLPPR5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLPPR5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLPPR5	hsa-miR-4803	99.899	NM_001010861
PLPPR5	hsa-miR-944	99.3226	NM_001010861
PLPPR5	hsa-miR-302c-5p	99.0242	NM_001010861
PLPPR5	hsa-miR-340-5p	96.8367	NM_001010861
PLPPR5	hsa-miR-4324	95.7647	NM_001010861
PLPPR5	hsa-miR-3127-3p	94.4648	NM_001010861
PLPPR5	hsa-miR-6756-3p	94.4648	NM_001010861
PLPPR5	hsa-miR-323a-3p	94.0255	NM_001010861
PLPPR5	hsa-miR-1193	93.7728	NM_001010861
PLPPR5	hsa-miR-548c-3p	93.7498	NM_001010861
PLPPR5	hsa-miR-1200	93.5107	NM_001010861
PLPPR5	hsa-miR-93-3p	93.3078	NM_001010861
PLPPR5	hsa-miR-6069	93.1471	NM_001010861
PLPPR5	hsa-miR-5692a	93.0307	NM_001010861
PLPPR5	hsa-miR-130a-5p	92.9156	NM_001010861
PLPPR5	hsa-miR-3163	90.6777	NM_001010861
PLPPR5	hsa-miR-6504-3p	90.5164	NM_001010861
PLPPR5	hsa-miR-10399-5p	90.5164	NM_001010861
PLPPR5	hsa-miR-12136	90.1479	NM_001010861
PLPPR5	hsa-miR-3658	89.9109	NM_001010861
PLPPR5	hsa-miR-548ah-5p	89.564	NM_001010861
PLPPR5	hsa-miR-3609	89.564	NM_001010861
PLPPR5	hsa-miR-6894-3p	89.2575	NM_001010861
PLPPR5	hsa-miR-4261	88.5981	NM_001010861
PLPPR5	hsa-miR-609	87.7235	NM_001010861
PLPPR5	hsa-miR-487a-5p	87.525	NM_001010861
PLPPR5	hsa-miR-487b-5p	87.525	NM_001010861
PLPPR5	hsa-miR-147b-5p	86.9723	NM_001010861
PLPPR5	hsa-miR-374a-3p	86.7878	NM_001010861
PLPPR5	hsa-miR-296-5p	85.9765	NM_001010861
PLPPR5	hsa-miR-4768-3p	85.7753	NM_001010861
PLPPR5	hsa-miR-4682	85.3105	NM_001010861
PLPPR5	hsa-miR-3688-3p	85.188	NM_001010861
PLPPR5	hsa-miR-377-3p	84.3573	NM_001010861
PLPPR5	hsa-miR-335-3p	84.1326	NM_001010861
PLPPR5	hsa-miR-4491	83.1725	NM_001010861
PLPPR5	hsa-miR-4657	83.1725	NM_001010861
PLPPR5	hsa-miR-219b-5p	82.4178	NM_001010861
PLPPR5	hsa-miR-4447	81.5361	NM_001010861
PLPPR5	hsa-miR-9-5p	81.0071	NM_001010861
PLPPR5	hsa-miR-518a-5p	80.92	NM_001010861
PLPPR5	hsa-miR-527	80.92	NM_001010861

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Motifs and transcription factors (TFs) regulating PLPPR5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."