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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLPBP

Summary for PLPBP

Gene information	Gene symbol	PLPBP
	Ensembl ID	ENSG00000147471
	Entrez ID	11212
	Gene name	pyridoxal phosphate binding protein
	Synonyms	PROSC
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PLPBP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.545287	0.00e+00

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Expression of PLPBP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLPBP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLPBP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLPBP	hsa-miR-875-3p	96.7869	NM_007198
PLPBP	hsa-miR-4775	93.0367	NM_007198
PLPBP	hsa-miR-1304-3p	90.4978	NM_007198
PLPBP	hsa-miR-4770	90.4292	NM_007198
PLPBP	hsa-miR-143-3p	90.4292	NM_007198
PLPBP	hsa-miR-302f	89.767	NM_007198
PLPBP	hsa-miR-153-5p	89.0226	NM_007198
PLPBP	hsa-miR-1271-3p	88.9804	NM_007198
PLPBP	hsa-miR-550a-5p	88.9804	NM_007198
PLPBP	hsa-miR-550a-3-5p	88.9804	NM_007198
PLPBP	hsa-miR-520f-5p	88.9451	NM_007198
PLPBP	hsa-miR-6088	87.6173	NM_007198
PLPBP	hsa-miR-939-3p	86.1767	NM_007198
PLPBP	hsa-miR-490-3p	85.9363	NM_007198
PLPBP	hsa-miR-2052	85.1106	NM_007198
PLPBP	hsa-miR-6515-3p	84.8131	NM_007198
PLPBP	hsa-miR-33a-3p	84.756	NM_007198
PLPBP	hsa-miR-135b-3p	81.8311	NM_007198
PLPBP	hsa-miR-135a-2-3p	81.8311	NM_007198
PLPBP	hsa-miR-7151-3p	80.8937	NM_007198
PLPBP	hsa-miR-11181-3p	80.3522	NM_007198

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Motifs and transcription factors (TFs) regulating PLPBP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."