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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLP1

Summary for PLP1

Gene information	Gene symbol	PLP1
	Ensembl ID	ENSG00000123560
	Entrez ID	5354
	Gene name	proteolipid protein 1
	Synonyms	GPM6C\|PLP\|SPG2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PLP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	1.17153	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.19393	0.00e+00

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Expression of PLP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLP1	hsa-miR-4775	99.2922	NM_199478
PLP1	hsa-miR-6867-5p	98.8086	NM_199478
PLP1	hsa-miR-590-3p	97.0149	NM_199478
PLP1	hsa-miR-3611	95.5382	NM_000533
PLP1	hsa-miR-3663-3p	94.725	NM_000533
PLP1	hsa-miR-4768-3p	94.5356	NM_199478
PLP1	hsa-miR-501-5p	94.493	NM_000533
PLP1	hsa-miR-29b-2-5p	94.1465	NM_000533
PLP1	hsa-miR-130b-5p	92.9132	NM_000533
PLP1	hsa-miR-2115-3p	91.9447	NM_199478
PLP1	hsa-miR-487b-5p	91.183	NM_000533
PLP1	hsa-miR-487a-5p	91.183	NM_000533
PLP1	hsa-miR-500b-5p	89.8826	NM_000533
PLP1	hsa-miR-362-5p	89.8826	NM_000533
PLP1	hsa-miR-6736-3p	89.3111	NM_000533
PLP1	hsa-miR-1910-3p	88.6505	NM_199478
PLP1	hsa-miR-6511a-5p	88.6505	NM_199478
PLP1	hsa-miR-4753-3p	88.3587	NM_000533
PLP1	hsa-miR-3074-3p	87.7572	NM_199478
PLP1	hsa-miR-509-3p	87.6083	NM_000533
PLP1	hsa-miR-6845-3p	87.5621	NM_000533
PLP1	hsa-miR-6868-3p	87.0979	NM_000533
PLP1	hsa-miR-6787-3p	86.9607	NM_000533
PLP1	hsa-miR-3192-5p	86.0502	NM_199478
PLP1	hsa-miR-1297	85.6855	NM_199478
PLP1	hsa-miR-26a-5p	85.6855	NM_199478
PLP1	hsa-miR-26b-5p	85.6855	NM_199478
PLP1	hsa-miR-4465	85.6855	NM_199478
PLP1	hsa-miR-618	85.2052	NM_000533
PLP1	hsa-miR-29c-3p	84.8902	NM_000533
PLP1	hsa-miR-29a-3p	84.8902	NM_000533
PLP1	hsa-miR-29b-3p	84.8902	NM_000533
PLP1	hsa-miR-8085	84.3778	NM_000533
PLP1	hsa-miR-6731-5p	84.3778	NM_000533
PLP1	hsa-miR-10527-5p	83.2152	NM_000533
PLP1	hsa-miR-511-3p	82.9742	NM_000533
PLP1	hsa-miR-4289	82.3778	NM_000533
PLP1	hsa-miR-888-5p	82.3192	NM_000533
PLP1	hsa-miR-1275	81.1937	NM_199478
PLP1	hsa-miR-1236-3p	80.7041	NM_000533

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Motifs and transcription factors (TFs) regulating PLP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLP1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PLP1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
PLP1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PLP1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PLP1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PLP1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."