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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLEKHF2

Summary for PLEKHF2

Gene information	Gene symbol	PLEKHF2
	Ensembl ID	ENSG00000175895
	Entrez ID	79666
	Gene name	pleckstrin homology and FYVE domain containing 2
	Synonyms	FLJ13187\|PHAFIN2\|ZFYVE18
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PLEKHF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.25254	1.46e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.30308	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.652766	1.21e-36

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Expression of PLEKHF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLEKHF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLEKHF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLEKHF2	hsa-miR-520d-5p	98.0942	NM_024613
PLEKHF2	hsa-miR-524-5p	98.0942	NM_024613
PLEKHF2	hsa-miR-7157-3p	97.5583	NM_024613
PLEKHF2	hsa-miR-6737-3p	97.5583	NM_024613
PLEKHF2	hsa-miR-607	96.9967	NM_024613
PLEKHF2	hsa-miR-5008-3p	96.7137	NM_024613
PLEKHF2	hsa-miR-587	96.6741	NM_024613
PLEKHF2	hsa-miR-3649	96.4979	NM_024613
PLEKHF2	hsa-miR-6715a-3p	95.2132	NM_024613
PLEKHF2	hsa-miR-3679-3p	94.6923	NM_024613
PLEKHF2	hsa-miR-107	94.4308	NM_024613
PLEKHF2	hsa-miR-103a-3p	94.4308	NM_024613
PLEKHF2	hsa-miR-12123	94.0327	NM_024613
PLEKHF2	hsa-miR-3688-3p	93.9165	NM_024613
PLEKHF2	hsa-miR-218-5p	93.2919	NM_024613
PLEKHF2	hsa-miR-6740-5p	93.2019	NM_024613
PLEKHF2	hsa-miR-1277-5p	91.752	NM_024613
PLEKHF2	hsa-miR-5582-5p	90.7239	NM_024613
PLEKHF2	hsa-miR-32-3p	89.9912	NM_024613
PLEKHF2	hsa-miR-124-3p	89.648	NM_024613
PLEKHF2	hsa-miR-506-3p	89.648	NM_024613
PLEKHF2	hsa-miR-3663-3p	89.3953	NM_024613
PLEKHF2	hsa-miR-1827	89.0297	NM_024613
PLEKHF2	hsa-miR-199b-5p	88.4351	NM_024613
PLEKHF2	hsa-miR-199a-5p	88.4351	NM_024613
PLEKHF2	hsa-miR-380-5p	88.2061	NM_024613
PLEKHF2	hsa-miR-563	88.176	NM_024613
PLEKHF2	hsa-miR-7849-3p	87.911	NM_024613
PLEKHF2	hsa-miR-593-5p	87.2216	NM_024613
PLEKHF2	hsa-miR-9851-3p	87.2216	NM_024613
PLEKHF2	hsa-miR-892c-5p	86.7272	NM_024613
PLEKHF2	hsa-miR-4524b-3p	86.1164	NM_024613
PLEKHF2	hsa-miR-3942-3p	85.7205	NM_024613
PLEKHF2	hsa-miR-550a-3p	85.2028	NM_024613
PLEKHF2	hsa-miR-200c-5p	85.1535	NM_024613
PLEKHF2	hsa-miR-616-5p	84.731	NM_024613
PLEKHF2	hsa-miR-373-5p	84.731	NM_024613
PLEKHF2	hsa-miR-371b-5p	84.731	NM_024613
PLEKHF2	hsa-miR-3065-5p	84.6406	NM_024613
PLEKHF2	hsa-miR-3148	84.5375	NM_024613
PLEKHF2	hsa-miR-4694-3p	84.4717	NM_024613
PLEKHF2	hsa-miR-549a-3p	83.6675	NM_024613
PLEKHF2	hsa-miR-1468-3p	83.667	NM_024613
PLEKHF2	hsa-miR-3140-5p	83.4012	NM_024613
PLEKHF2	hsa-miR-3613-3p	83.0978	NM_024613
PLEKHF2	hsa-miR-1305	82.0968	NM_024613
PLEKHF2	hsa-miR-3924	80.6335	NM_024613

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Motifs and transcription factors (TFs) regulating PLEKHF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLEKHF2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PLEKHF2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PLEKHF2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PLEKHF2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PLEKHF2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PLEKHF2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PLEKHF2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PLEKHF2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PLEKHF2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PLEKHF2	transfac_pro__M00652	NRF1 (directAnnotation).
PLEKHF2	hdpi__ETV4	ETV4 (directAnnotation).
PLEKHF2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PLEKHF2	transfac_pro__M04866	HDAC2 (directAnnotation).
PLEKHF2	jaspar__MA1122.1	TFDP1 (directAnnotation).
PLEKHF2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
PLEKHF2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PLEKHF2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PLEKHF2	metacluster_135.11	NR2C2 (directAnnotation).
PLEKHF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PLEKHF2	tfdimers__MD00038	TFAP2C (directAnnotation).
PLEKHF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLEKHF2	metacluster_7.13	ZFX (directAnnotation).
PLEKHF2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PLEKHF2	cisbp__M00968	MTF2 (directAnnotation).
PLEKHF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PLEKHF2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PLEKHF2	cisbp__M00341	PAX6 (directAnnotation).
PLEKHF2	metacluster_198.3	ZFP64 (directAnnotation).
PLEKHF2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLEKHF2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PLEKHF2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PLEKHF2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PLEKHF2	cisbp__M00788	ZFY (inferredBy_Orthology).
PLEKHF2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PLEKHF2	metacluster_175.1	ZNF283 (directAnnotation).
PLEKHF2	hdpi__ZNF304	ZNF304 (directAnnotation).
PLEKHF2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PLEKHF2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PLEKHF2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PLEKHF2	transfac_pro__M01199	TRIM28 (directAnnotation).
PLEKHF2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PLEKHF2	metacluster_151.2	ZNF23 (directAnnotation).
PLEKHF2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PLEKHF2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PLEKHF2	transfac_pro__M03806	ZBTB7C (directAnnotation).
PLEKHF2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PLEKHF2	hdpi__NRL	NRL (directAnnotation).
PLEKHF2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PLEKHF2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PLEKHF2	hdpi__FEZF2	FEZF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."