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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLEKHB2

Summary for PLEKHB2

Gene information	Gene symbol	PLEKHB2
	Ensembl ID	ENSG00000115762
	Entrez ID	55041
	Gene name	pleckstrin homology domain containing B2
	Synonyms	EVT2\|FLJ20783
	Gene type	protein_coding
	UniProtAcc	Q96CS7

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Dataset with differentially expressed gene: PLEKHB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.295017	1.01e-39
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.29517	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.255375	5.93e-09
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.258688	5.56e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.464061	0.00e+00

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Expression of PLEKHB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLEKHB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLEKHB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLEKHB2	hsa-miR-4719	98.4293	NM_001267068
PLEKHB2	hsa-miR-4705	97.3175	NM_001267068
PLEKHB2	hsa-miR-618	93.6993	NM_001267064
PLEKHB2	hsa-miR-342-3p	93.4729	NM_001267064
PLEKHB2	hsa-miR-1246	92.0288	NM_001267064
PLEKHB2	hsa-miR-3667-5p	91.3504	NM_001267068
PLEKHB2	hsa-miR-92b-3p	91.2196	NM_001267068
PLEKHB2	hsa-miR-32-5p	91.2196	NM_001267068
PLEKHB2	hsa-miR-92a-3p	91.2196	NM_001267068
PLEKHB2	hsa-miR-3173-5p	90.9278	NM_001267064
PLEKHB2	hsa-miR-6799-3p	90.9278	NM_001267064
PLEKHB2	hsa-miR-5695	90.7853	NM_001267068
PLEKHB2	hsa-miR-4491	89.7462	NM_001267064
PLEKHB2	hsa-miR-4657	89.7462	NM_001267064
PLEKHB2	hsa-miR-25-3p	89.0222	NM_001267068
PLEKHB2	hsa-miR-363-3p	89.0222	NM_001267068
PLEKHB2	hsa-miR-367-3p	89.0222	NM_001267068
PLEKHB2	hsa-miR-548aj-3p	87.9913	NM_001267064
PLEKHB2	hsa-miR-548x-3p	87.9913	NM_001267064
PLEKHB2	hsa-miR-31-3p	87.2912	NM_001267068
PLEKHB2	hsa-miR-570-3p	87.0702	NM_001267064
PLEKHB2	hsa-miR-155-5p	86.3904	NM_001267064
PLEKHB2	hsa-miR-548j-3p	86.0704	NM_001267064
PLEKHB2	hsa-miR-548aq-3p	86.0704	NM_001267064
PLEKHB2	hsa-miR-548ah-3p	86.0704	NM_001267064
PLEKHB2	hsa-miR-548ae-3p	86.0704	NM_001267064
PLEKHB2	hsa-miR-548am-3p	86.0704	NM_001267064
PLEKHB2	hsa-miR-8065	85.8448	NM_001267064
PLEKHB2	hsa-miR-1323	83.5419	NM_001267064
PLEKHB2	hsa-miR-6768-5p	82.457	NM_001267064
PLEKHB2	hsa-miR-548f-3p	82.1107	NM_001267064
PLEKHB2	hsa-miR-548az-3p	82.1107	NM_001267064
PLEKHB2	hsa-miR-548a-3p	82.1107	NM_001267064
PLEKHB2	hsa-miR-548e-3p	82.1107	NM_001267064
PLEKHB2	hsa-miR-548bc	82.1107	NM_001267064
PLEKHB2	hsa-miR-548ar-3p	80.7264	NM_001267064

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Motifs and transcription factors (TFs) regulating PLEKHB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLEKHB2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PLEKHB2	transfac_pro__M06140	ZNF250 (directAnnotation).
PLEKHB2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PLEKHB2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PLEKHB2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLEKHB2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PLEKHB2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PLEKHB2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PLEKHB2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PLEKHB2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PLEKHB2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PLEKHB2	transfac_pro__M01253	CNOT3 (directAnnotation).
PLEKHB2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PLEKHB2	cisbp__M00968	MTF2 (directAnnotation).
PLEKHB2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PLEKHB2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PLEKHB2	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PLEKHB2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PLEKHB2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PLEKHB2	transfac_pro__M07310	SP5 (directAnnotation).
PLEKHB2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PLEKHB2	transfac_pro__M00938	E2F1 (directAnnotation).
PLEKHB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PLEKHB2	transfac_pro__M04893	TAF1 (directAnnotation).
PLEKHB2	transfac_pro__M04817	ZBTB33 (directAnnotation).
PLEKHB2	transfac_pro__M12697	ZNF142 (directAnnotation).
PLEKHB2	tfdimers__MD00364	WT1 (directAnnotation).
PLEKHB2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PLEKHB2	transfac_pro__M01973	PLAG1 (directAnnotation).
PLEKHB2	metacluster_198.3	ZFP64 (directAnnotation).
PLEKHB2	transfac_pro__M01303	SP1 (directAnnotation).
PLEKHB2	metacluster_143.13	ZBTB7A (directAnnotation).
PLEKHB2	transfac_pro__M07387	ZBTB7A (directAnnotation).
PLEKHB2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PLEKHB2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PLEKHB2	transfac_pro__M02898	SMAD3 (directAnnotation).
PLEKHB2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PLEKHB2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
PLEKHB2	transfac_pro__M07329	SP7 (directAnnotation).
PLEKHB2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PLEKHB2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PLEKHB2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PLEKHB2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
PLEKHB2	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
PLEKHB2	transfac_pro__M06334	ZNF782 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."