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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PLEKHA1

Summary for PLEKHA1

Gene information	Gene symbol	PLEKHA1
	Ensembl ID	ENSG00000107679
	Entrez ID	59338
	Gene name	pleckstrin homology domain containing A1
	Synonyms	TAPP1
	Gene type	protein_coding
	UniProtAcc	Q9HB21

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Dataset with differentially expressed gene: PLEKHA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.34435	3.97e-16
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.304345	2.50e-15
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.67091	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.264594	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.369553	3.20e-22

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Expression of PLEKHA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLEKHA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLEKHA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLEKHA1	hsa-miR-3662	98.1192	NM_001001974
PLEKHA1	hsa-miR-5692a	97.163	NM_001195608
PLEKHA1	hsa-miR-449c-5p	96.4571	NM_001195608
PLEKHA1	hsa-miR-34b-5p	96.4571	NM_001195608
PLEKHA1	hsa-miR-2682-5p	96.4571	NM_001195608
PLEKHA1	hsa-miR-25-3p	96.345	NM_001195608
PLEKHA1	hsa-miR-590-5p	96.0145	NM_001195608
PLEKHA1	hsa-miR-4786-5p	96.005	NM_001195608
PLEKHA1	hsa-miR-107	95.9898	NM_001195608
PLEKHA1	hsa-miR-103a-3p	95.9898	NM_001195608
PLEKHA1	hsa-miR-7154-5p	95.7761	NM_001001974
PLEKHA1	hsa-miR-92b-3p	95.5809	NM_001195608
PLEKHA1	hsa-miR-32-5p	95.5809	NM_001195608
PLEKHA1	hsa-miR-92a-3p	95.5809	NM_001195608
PLEKHA1	hsa-miR-21-5p	95.4937	NM_001195608
PLEKHA1	hsa-miR-363-3p	95.4364	NM_001195608
PLEKHA1	hsa-miR-367-3p	95.4364	NM_001195608
PLEKHA1	hsa-miR-153-5p	94.9707	NM_001195608
PLEKHA1	hsa-miR-4504	94.7673	NM_001195608
PLEKHA1	hsa-miR-4704-3p	94.1161	NM_001195608
PLEKHA1	hsa-miR-4715-3p	93.8884	NM_001001974
PLEKHA1	hsa-miR-3168	93.7177	NM_001195608
PLEKHA1	hsa-miR-1827	93.0179	NM_001195608
PLEKHA1	hsa-miR-577	92.2026	NM_001195608
PLEKHA1	hsa-miR-5579-3p	92.1584	NM_001195608
PLEKHA1	hsa-miR-5584-3p	91.9614	NM_001195608
PLEKHA1	hsa-miR-607	91.7287	NM_001195608
PLEKHA1	hsa-miR-590-3p	90.995	NM_001001974
PLEKHA1	hsa-miR-155-5p	90.0097	NM_001001974
PLEKHA1	hsa-miR-1206	90.0036	NM_001001974
PLEKHA1	hsa-miR-6874-3p	89.6574	NM_001195608
PLEKHA1	hsa-miR-148b-5p	89.6574	NM_001195608
PLEKHA1	hsa-miR-6715b-5p	89.6332	NM_001195608
PLEKHA1	hsa-miR-4269	89.6332	NM_001195608
PLEKHA1	hsa-miR-4766-5p	88.8331	NM_001001974
PLEKHA1	hsa-miR-582-5p	88.712	NM_001195608
PLEKHA1	hsa-miR-3646	88.7044	NM_001001974
PLEKHA1	hsa-miR-7114-5p	88.6035	NM_001195608
PLEKHA1	hsa-miR-4718	88.3461	NM_001195608
PLEKHA1	hsa-miR-7159-3p	88.2886	NM_001195608
PLEKHA1	hsa-miR-3973	88.2708	NM_001001974
PLEKHA1	hsa-miR-4524b-5p	88.2	NM_001195608
PLEKHA1	hsa-miR-4524a-5p	88.2	NM_001195608
PLEKHA1	hsa-miR-1324	87.9526	NM_001001974
PLEKHA1	hsa-miR-202-5p	86.9953	NM_001195608
PLEKHA1	hsa-miR-195-5p	86.7215	NM_001195608
PLEKHA1	hsa-miR-4775	86.2251	NM_001001974
PLEKHA1	hsa-miR-515-5p	84.8447	NM_001195608
PLEKHA1	hsa-miR-519e-5p	84.8447	NM_001195608
PLEKHA1	hsa-miR-4699-3p	84.8299	NM_001195608

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Motifs and transcription factors (TFs) regulating PLEKHA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLEKHA1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PLEKHA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PLEKHA1	transfac_pro__M07397	ZNF148 (directAnnotation).
PLEKHA1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PLEKHA1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PLEKHA1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PLEKHA1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PLEKHA1	metacluster_7.13	ZFX (directAnnotation).
PLEKHA1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PLEKHA1	transfac_pro__M01175	ZBTB7B (directAnnotation).
PLEKHA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PLEKHA1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PLEKHA1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PLEKHA1	transfac_pro__M01303	SP1 (directAnnotation).
PLEKHA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLEKHA1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PLEKHA1	transfac_pro__M02090	E2F4 (directAnnotation).
PLEKHA1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PLEKHA1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PLEKHA1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PLEKHA1	transfac_pro__M02089	E2F3 (directAnnotation).
PLEKHA1	metacluster_3.14	WT1; WT1 (directAnnotation).
PLEKHA1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PLEKHA1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PLEKHA1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PLEKHA1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PLEKHA1	cisbp__M07938	E2F1 (directAnnotation).
PLEKHA1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PLEKHA1	transfac_pro__M07436	WT1 (directAnnotation).
PLEKHA1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PLEKHA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PLEKHA1	transfac_pro__M02898	SMAD3 (directAnnotation).
PLEKHA1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PLEKHA1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PLEKHA1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PLEKHA1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PLEKHA1	transfac_pro__M04617	ZBTB7A (directAnnotation).
PLEKHA1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PLEKHA1	transfac_pro__M07387	ZBTB7A (directAnnotation).
PLEKHA1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PLEKHA1	hdpi__HIP2	UBE2K (directAnnotation).
PLEKHA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PLEKHA1	transfac_pro__M04893	TAF1 (directAnnotation).
PLEKHA1	transfac_pro__M03876	ZBTB33 (directAnnotation).
PLEKHA1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PLEKHA1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PLEKHA1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PLEKHA1	jaspar__MA1483.2	ELF2 (directAnnotation).
PLEKHA1	transfac_pro__M04826	EP300 (directAnnotation).
PLEKHA1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PLEKHA1	"Citric acid"	DB04272	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."