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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLCB4

Summary for PLCB4

Gene information	Gene symbol	PLCB4
	Ensembl ID	ENSG00000101333
	Entrez ID	5332
	Gene name	phospholipase C beta 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q15147

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Dataset with differentially expressed gene: PLCB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.475502	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.43757	0.00e+00

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Expression of PLCB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLCB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLCB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLCB4	hsa-miR-335-3p	99.6742	NM_001172646
PLCB4	hsa-miR-5010-3p	99.633	NM_000933
PLCB4	hsa-miR-466	99.5061	NM_001172646
PLCB4	hsa-miR-5011-5p	99.2598	NM_001172646
PLCB4	hsa-miR-4789-3p	99.1979	NM_000933
PLCB4	hsa-miR-4775	95.8167	NM_000933
PLCB4	hsa-miR-96-3p	95.5569	NM_000933
PLCB4	hsa-miR-2113	94.5122	NM_000933
PLCB4	hsa-miR-4789-5p	94.2399	NM_001172646
PLCB4	hsa-miR-4496	94.1949	NM_000933
PLCB4	hsa-miR-96-5p	94.0161	NM_001172646
PLCB4	hsa-miR-548p	93.075	NM_001172646
PLCB4	hsa-miR-1271-5p	92.9999	NM_001172646
PLCB4	hsa-miR-12133	92.9999	NM_001172646
PLCB4	hsa-miR-6529-3p	92.9273	NM_001172646
PLCB4	hsa-miR-6889-3p	92.8958	NM_001172646
PLCB4	hsa-miR-3622b-5p	92.8653	NM_000933
PLCB4	hsa-miR-190a-3p	92.4361	NM_001172646
PLCB4	hsa-miR-1303	92.237	NM_001172646
PLCB4	hsa-miR-382-5p	92.2269	NM_000933
PLCB4	hsa-miR-19b-2-5p	92.0769	NM_000933
PLCB4	hsa-miR-19a-5p	92.0769	NM_000933
PLCB4	hsa-miR-19b-1-5p	92.0769	NM_000933
PLCB4	hsa-miR-365b-3p	89.906	NM_001172646
PLCB4	hsa-miR-365a-3p	89.906	NM_001172646
PLCB4	hsa-miR-450b-5p	88.4064	NM_000933
PLCB4	hsa-miR-708-3p	88.3825	NM_000933
PLCB4	hsa-miR-4760-3p	88.2597	NM_000933
PLCB4	hsa-miR-3145-3p	87.9997	NM_000933
PLCB4	hsa-miR-599	87.7557	NM_000933
PLCB4	hsa-miR-4643	87.4363	NM_000933
PLCB4	hsa-miR-4261	85.8976	NM_000933
PLCB4	hsa-miR-2052	85.6544	NM_000933
PLCB4	hsa-miR-3924	85.1584	NM_000933
PLCB4	hsa-miR-942-3p	84.9651	NM_001172646
PLCB4	hsa-miR-507	84.2974	NM_000933
PLCB4	hsa-miR-5001-3p	84.0088	NM_001172646
PLCB4	hsa-miR-4451	82.9545	NM_000933
PLCB4	hsa-miR-591	82.5433	NM_001172646
PLCB4	hsa-miR-183-5p	81.9248	NM_001172646
PLCB4	hsa-miR-3680-3p	81.6978	NM_000933
PLCB4	hsa-miR-7152-5p	81.2952	NM_000933
PLCB4	hsa-miR-381-3p	81.1752	NM_001172646
PLCB4	hsa-miR-300	81.1752	NM_001172646
PLCB4	hsa-miR-590-3p	81.0129	NM_000933
PLCB4	hsa-miR-147b-5p	80.2686	NM_000933
PLCB4	hsa-miR-3925-5p	80.1566	NM_001172646
PLCB4	hsa-miR-3123	80.1566	NM_001172646
PLCB4	hsa-miR-7112-3p	80.0837	NM_000933
PLCB4	hsa-miR-182-5p	80.0114	NM_001172646

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Motifs and transcription factors (TFs) regulating PLCB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLCB4	metacluster_7.13	ZFX (directAnnotation).
PLCB4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PLCB4	metacluster_151.2	ZNF23 (directAnnotation).
PLCB4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PLCB4	transfac_pro__M05479	ZNF580 (directAnnotation).
PLCB4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PLCB4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLCB4	hdpi__ETV4	ETV4 (directAnnotation).
PLCB4	jaspar__MA0748.2	YY2 (directAnnotation).
PLCB4	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PLCB4	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PLCB4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PLCB4	jaspar__MA0079.5	SP1 (directAnnotation).
PLCB4	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
PLCB4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PLCB4	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PLCB4	transfac_pro__M02089	E2F3 (directAnnotation).
PLCB4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PLCB4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PLCB4	transfac_pro__M04817	ZBTB33 (directAnnotation).
PLCB4	metacluster_143.13	ZBTB7A (directAnnotation).
PLCB4	tfdimers__MD00483	ZBTB14 (directAnnotation).
PLCB4	cisbp__M07938	E2F1 (directAnnotation).
PLCB4	cisbp__M00968	MTF2 (directAnnotation).
PLCB4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PLCB4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PLCB4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PLCB4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PLCB4	jaspar__MA1122.1	TFDP1 (directAnnotation).
PLCB4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."