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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLAA

Summary for PLAA

Gene information	Gene symbol	PLAA
	Ensembl ID	ENSG00000137055
	Entrez ID	9373
	Gene name	phospholipase A2 activating protein
	Synonyms	DOA1\|FLJ11281\|FLJ12699\|PLA2P\|PLAP
	Gene type	protein_coding
	UniProtAcc	Q9Y263

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Dataset with differentially expressed gene: PLAA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.20561	1.98e-02

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Expression of PLAA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLAA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLAA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLAA	hsa-miR-19b-3p	95.1515	NM_001031689
PLAA	hsa-miR-19a-3p	95.1515	NM_001031689
PLAA	hsa-miR-152-3p	92.6523	NM_001031689
PLAA	hsa-miR-148a-3p	92.6523	NM_001031689
PLAA	hsa-miR-148b-3p	92.6523	NM_001031689
PLAA	hsa-miR-10395-3p	91.8858	NM_001031689
PLAA	hsa-miR-6499-3p	91.7436	NM_001321546
PLAA	hsa-miR-1323	91.6036	NM_001321546
PLAA	hsa-miR-4777-3p	90.8154	NM_001321546
PLAA	hsa-miR-548aw	88.8346	NM_001031689
PLAA	hsa-miR-454-3p	87.9046	NM_001031689
PLAA	hsa-miR-548o-3p	87.8255	NM_001321546
PLAA	hsa-miR-4282	87.1314	NM_001031689
PLAA	hsa-miR-4753-3p	86.9762	NM_001321546
PLAA	hsa-miR-6776-3p	86.486	NM_001321546
PLAA	hsa-miR-4652-3p	84.3431	NM_001321546
PLAA	hsa-miR-130a-5p	84.2241	NM_001321546
PLAA	hsa-miR-590-3p	84.1973	NM_001031689
PLAA	hsa-miR-548e-5p	83.9332	NM_001321546
PLAA	hsa-miR-301b-3p	83.6525	NM_001031689
PLAA	hsa-miR-4295	83.6525	NM_001031689
PLAA	hsa-miR-130b-3p	83.6525	NM_001031689
PLAA	hsa-miR-3666	83.6525	NM_001031689
PLAA	hsa-miR-130a-3p	83.6525	NM_001031689
PLAA	hsa-miR-301a-3p	83.6525	NM_001031689
PLAA	hsa-miR-7856-5p	83.2186	NM_001321546
PLAA	hsa-miR-6768-5p	82.9789	NM_001031689
PLAA	hsa-miR-21-5p	82.4213	NM_001321546
PLAA	hsa-miR-6867-5p	82.3069	NM_001031689
PLAA	hsa-miR-450a-2-3p	82.2008	NM_001321546
PLAA	hsa-miR-517-5p	81.7742	NM_001321546
PLAA	hsa-miR-892c-5p	81.4959	NM_001321546

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Motifs and transcription factors (TFs) regulating PLAA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."