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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PLA2G4A

Summary for PLA2G4A

Gene information	Gene symbol	PLA2G4A
	Ensembl ID	ENSG00000116711
	Entrez ID	5321
	Gene name	phospholipase A2 group IVA
	Synonyms	cPLA2-alpha\|PLA2G4
	Gene type	protein_coding
	UniProtAcc	P47712

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Dataset with differentially expressed gene: PLA2G4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.458841	2.84e-38

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Expression of PLA2G4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLA2G4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLA2G4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLA2G4A	hsa-miR-543	93.1019	NM_024420
PLA2G4A	hsa-miR-203b-3p	91.6959	NM_024420
PLA2G4A	hsa-miR-7855-5p	90.4283	NM_024420
PLA2G4A	hsa-miR-33a-3p	90.2778	NM_001311193
PLA2G4A	hsa-miR-144-3p	88.424	NM_024420
PLA2G4A	hsa-miR-3171	88.2347	NM_024420
PLA2G4A	hsa-miR-4697-3p	86.8485	NM_001311193
PLA2G4A	hsa-miR-8485	86.7081	NM_024420
PLA2G4A	hsa-miR-448	86.3629	NM_024420
PLA2G4A	hsa-miR-485-3p	85.1968	NM_024420
PLA2G4A	hsa-miR-539-3p	85.1968	NM_024420
PLA2G4A	hsa-miR-4714-3p	83.3033	NM_024420
PLA2G4A	hsa-miR-297	81.6985	NM_024420
PLA2G4A	hsa-miR-4262	80.1731	NM_024420

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Motifs and transcription factors (TFs) regulating PLA2G4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PLA2G4A	"Darapladib"	DB06311	small molecule
PLA2G4A	"Fluticasone propionate"	DB00588	small molecule
PLA2G4A	"Fluticasone"	DB13867	small molecule
PLA2G4A	"Niflumic acid"	DB04552	small molecule
PLA2G4A	"Procaine"	DB00721	small molecule
PLA2G4A	"Quinacrine"	DB01103	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."