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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLA2G12A

Summary for PLA2G12A

Gene information	Gene symbol	PLA2G12A
	Ensembl ID	ENSG00000123739
	Entrez ID	81579
	Gene name	phospholipase A2 group XIIA
	Synonyms	PLA2G12
	Gene type	protein_coding
	UniProtAcc	Q9BZM1

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Dataset with differentially expressed gene: PLA2G12A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.443761	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.58735	0.00e+00

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Expression of PLA2G12A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLA2G12A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLA2G12A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLA2G12A	hsa-miR-130a-5p	98.0818	NM_030821
PLA2G12A	hsa-miR-590-3p	94.2102	NM_030821
PLA2G12A	hsa-miR-511-3p	94.1101	NM_030821
PLA2G12A	hsa-miR-4328	93.6529	NM_030821
PLA2G12A	hsa-miR-944	92.4062	NM_030821
PLA2G12A	hsa-miR-1272	90.5641	NM_030821
PLA2G12A	hsa-miR-9983-3p	89.4377	NM_030821
PLA2G12A	hsa-miR-5580-3p	88.7575	NM_030821
PLA2G12A	hsa-miR-582-5p	88.2494	NM_030821
PLA2G12A	hsa-miR-142-3p	88.1597	NM_030821
PLA2G12A	hsa-miR-3613-5p	85.9777	NM_030821
PLA2G12A	hsa-miR-129-5p	85.9332	NM_030821
PLA2G12A	hsa-miR-5584-5p	84.1323	NM_030821
PLA2G12A	hsa-miR-12135	83.4298	NM_030821
PLA2G12A	hsa-miR-5692a	81.584	NM_030821
PLA2G12A	hsa-miR-30e-5p	80.6404	NM_030821
PLA2G12A	hsa-miR-30c-5p	80.6404	NM_030821
PLA2G12A	hsa-miR-30b-5p	80.6404	NM_030821
PLA2G12A	hsa-miR-30d-5p	80.6404	NM_030821
PLA2G12A	hsa-miR-30a-5p	80.6404	NM_030821

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Motifs and transcription factors (TFs) regulating PLA2G12A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLA2G12A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PLA2G12A	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PLA2G12A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PLA2G12A	transfac_pro__M00652	NRF1 (directAnnotation).
PLA2G12A	hdpi__ETV4	ETV4 (directAnnotation).
PLA2G12A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PLA2G12A	transfac_pro__M04866	HDAC2 (directAnnotation).
PLA2G12A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PLA2G12A	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."