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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PKP1

Summary for PKP1

Gene information	Gene symbol	PKP1
	Ensembl ID	ENSG00000081277
	Entrez ID	5317
	Gene name	plakophilin 1
	Synonyms	B6P
	Gene type	protein_coding
	UniProtAcc	Q13835

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Dataset with differentially expressed gene: PKP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.251829	7.46e-08

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Expression of PKP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PKP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PKP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PKP1	hsa-miR-489-3p	94.2152	NM_000299
PKP1	hsa-miR-4789-5p	92.1213	NM_000299
PKP1	hsa-miR-874-5p	90.1325	NM_000299
PKP1	hsa-miR-10527-5p	87.0515	NM_000299
PKP1	hsa-miR-6764-5p	86.9726	NM_000299
PKP1	hsa-miR-4283	86.4999	NM_000299
PKP1	hsa-miR-2392	86.2837	NM_000299
PKP1	hsa-miR-1915-5p	85.6028	NM_000299
PKP1	hsa-miR-3148	84.1297	NM_000299
PKP1	hsa-miR-1915-3p	83.5072	NM_000299
PKP1	hsa-miR-499a-3p	83.4634	NM_000299
PKP1	hsa-miR-499b-3p	83.4634	NM_000299
PKP1	hsa-miR-4328	81.824	NM_000299
PKP1	hsa-miR-6769a-3p	81.5786	NM_000299
PKP1	hsa-miR-7106-5p	80.0739	NM_000299
PKP1	hsa-miR-4731-5p	80.036	NM_000299
PKP1	hsa-miR-3913-3p	80.0197	NM_000299

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Motifs and transcription factors (TFs) regulating PKP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PKP1	transfac_pro__M04950	EGR1 (directAnnotation).
PKP1	transfac_pro__M04913	ZBTB7A (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."