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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PIP5K1A

Summary for PIP5K1A

Gene information	Gene symbol	PIP5K1A
	Ensembl ID	ENSG00000143398
	Entrez ID	8394
	Gene name	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PIP5K1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.332525	0.00e+00

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Expression of PIP5K1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PIP5K1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PIP5K1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PIP5K1A	hsa-miR-544b	97.0061	NM_001135636
PIP5K1A	hsa-miR-4524b-3p	95.5181	NM_001135636
PIP5K1A	hsa-miR-4324	94.5985	NM_001135636
PIP5K1A	hsa-miR-520d-5p	93.2494	NM_001135636
PIP5K1A	hsa-miR-524-5p	93.2494	NM_001135636
PIP5K1A	hsa-miR-3658	92.2674	NM_003557
PIP5K1A	hsa-miR-6868-3p	91.8933	NM_003557
PIP5K1A	hsa-miR-1248	91.7082	NM_003557
PIP5K1A	hsa-miR-7110-5p	91.0148	NM_003557
PIP5K1A	hsa-miR-6842-5p	91.0148	NM_003557
PIP5K1A	hsa-miR-6124	90.1132	NM_003557
PIP5K1A	hsa-miR-4778-3p	90.0058	NM_001135636
PIP5K1A	hsa-miR-802	88.7291	NM_003557
PIP5K1A	hsa-miR-548aa	88.7118	NM_003557
PIP5K1A	hsa-miR-548ap-3p	88.7118	NM_003557
PIP5K1A	hsa-miR-548t-3p	88.7118	NM_003557
PIP5K1A	hsa-miR-650	88.5273	NM_003557
PIP5K1A	hsa-miR-3612	88.5273	NM_003557
PIP5K1A	hsa-miR-6752-5p	87.8614	NM_003557
PIP5K1A	hsa-miR-6866-5p	87.8095	NM_003557
PIP5K1A	hsa-miR-3124-3p	86.2916	NM_001135636
PIP5K1A	hsa-miR-671-3p	85.6167	NM_001135636
PIP5K1A	hsa-miR-450b-3p	85.5719	NM_003557
PIP5K1A	hsa-miR-769-3p	82.6502	NM_003557
PIP5K1A	hsa-miR-3148	82.0649	NM_003557
PIP5K1A	hsa-miR-6835-5p	82.0592	NM_003557
PIP5K1A	hsa-miR-561-3p	81.9947	NM_003557
PIP5K1A	hsa-miR-4476	80.6403	NM_003557
PIP5K1A	hsa-miR-6876-5p	80.6403	NM_003557

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Motifs and transcription factors (TFs) regulating PIP5K1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PIP5K1A	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."