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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PIK3R1

Summary for PIK3R1

Gene information	Gene symbol	PIK3R1
	Ensembl ID	ENSG00000145675
	Entrez ID	5295
	Gene name	phosphoinositide-3-kinase regulatory subunit 1
	Synonyms	GRB1\|p85\|p85-ALPHA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PIK3R1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.254312	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.252264	3.50e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.365656	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.36026	2.66e-18
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.275745	6.29e-24
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.289624	2.24e-40
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.281555	2.10e-21
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.291387	8.22e-35
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.286764	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.294019	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.274252	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.43971	1.74e-24
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.500954	3.31e-28
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.726383	5.55e-17
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	0.499284	7.82e-03
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.526608	1.01e-34
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	0.369507	9.49e-33
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.365376	7.74e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.430083	2.71e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.31514	4.96e-19
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD4+ T cells	-0.534098	7.39e-10
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	-0.544386	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.538224	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	-0.364974	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.500042	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.511806	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.796943	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-1.33106	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-1.0862	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.67081	1.19e-11
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.350193	9.79e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.386819	7.63e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.29649	5.76e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.250487	1.01e-04
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	0.271237	3.94e-07

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Expression of PIK3R1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PIK3R1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PIK3R1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PIK3R1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PIK3R1	hsa-miR-5011-5p	100	NM_001242466
PIK3R1	hsa-miR-190a-3p	100	NM_181504
PIK3R1	hsa-miR-8485	99.6142	NM_181504
PIK3R1	hsa-miR-6835-3p	98.981	NM_001242466
PIK3R1	hsa-miR-4789-3p	97.3438	NM_001242466
PIK3R1	hsa-miR-5580-3p	97.1084	NM_001242466
PIK3R1	hsa-miR-208b-5p	96.3217	NM_001242466
PIK3R1	hsa-miR-208a-5p	96.3217	NM_001242466
PIK3R1	hsa-miR-3924	96.2848	NM_001242466
PIK3R1	hsa-miR-548c-3p	95.3688	NM_001242466
PIK3R1	hsa-miR-4778-5p	95.3494	NM_181504
PIK3R1	hsa-miR-646	94.9519	NM_001242466
PIK3R1	hsa-miR-548x-3p	94.8646	NM_001242466
PIK3R1	hsa-miR-548aj-3p	94.8646	NM_001242466
PIK3R1	hsa-miR-4713-5p	94.2759	NM_001242466
PIK3R1	hsa-miR-891b	94.1328	NM_001242466
PIK3R1	hsa-miR-548ar-3p	94.1015	NM_181504
PIK3R1	hsa-miR-548ah-3p	93.9639	NM_001242466
PIK3R1	hsa-miR-548aq-3p	93.9639	NM_001242466
PIK3R1	hsa-miR-548ae-3p	93.9639	NM_001242466
PIK3R1	hsa-miR-548j-3p	93.9639	NM_001242466
PIK3R1	hsa-miR-548am-3p	93.9639	NM_001242466
PIK3R1	hsa-miR-297	93.511	NM_181504
PIK3R1	hsa-miR-5588-3p	93.1132	NM_001242466
PIK3R1	hsa-miR-4646-3p	92.8911	NM_181504
PIK3R1	hsa-miR-498-3p	92.745	NM_001242466
PIK3R1	hsa-miR-548bc	92.7104	NM_181504
PIK3R1	hsa-miR-548e-3p	92.7104	NM_181504
PIK3R1	hsa-miR-548f-3p	92.7104	NM_181504
PIK3R1	hsa-miR-548az-3p	92.7104	NM_181504
PIK3R1	hsa-miR-548a-3p	92.6998	NM_181504
PIK3R1	hsa-miR-455-3p	92.4714	NM_181504
PIK3R1	hsa-miR-548g-3p	92.3686	NM_181504
PIK3R1	hsa-miR-9983-3p	92.2639	NM_181504
PIK3R1	hsa-miR-493-5p	92.1748	NM_001242466
PIK3R1	hsa-miR-548p	92.1631	NM_181504
PIK3R1	hsa-miR-7151-5p	92.1287	NM_001242466
PIK3R1	hsa-miR-12129	92.1241	NM_001242466
PIK3R1	hsa-miR-4433b-5p	91.9534	NM_001242466
PIK3R1	hsa-miR-552-5p	91.9227	NM_001242466
PIK3R1	hsa-miR-3662	91.7291	NM_181504
PIK3R1	hsa-miR-1207-3p	91.6664	NM_001242466
PIK3R1	hsa-miR-5681b	91.5658	NM_001242466
PIK3R1	hsa-miR-129-5p	91.5309	NM_181504
PIK3R1	hsa-miR-5002-5p	90.7994	NM_001242466
PIK3R1	hsa-miR-4422	90.6154	NM_001242466
PIK3R1	hsa-miR-196a-1-3p	89.816	NM_181504
PIK3R1	hsa-miR-222-3p	89.7116	NM_001242466
PIK3R1	hsa-miR-221-3p	89.7116	NM_001242466
PIK3R1	hsa-miR-3646	89.6748	NM_181504

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Motifs and transcription factors (TFs) regulating PIK3R1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PIK3R1	taipale_tf_pairs__GCM1_SOX2_RTRSGGGNNNATTGTKY_CAP_repr	GCM1; SOX2 (directAnnotation).
PIK3R1	taipale_tf_pairs__FOXJ2_PITX1_NTAATCCNNWMAACA_CAP_repr	FOXJ2; PITX1 (directAnnotation).
PIK3R1	transfac_pro__M04856	BATF (directAnnotation).
PIK3R1	homer__DGCACACGTG_MNT	MNT (directAnnotation).
PIK3R1	metacluster_71.2	EPAS1 (directAnnotation).
PIK3R1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PIK3R1	transfac_pro__M06727	PRDM6 (directAnnotation).
PIK3R1	cisbp__M00273	CRX (directAnnotation).
PIK3R1	transfac_pro__M06010	ZNF701 (directAnnotation).
PIK3R1	transfac_pro__M06339	ZNF425 (directAnnotation).
PIK3R1	transfac_pro__M01660	GABPA (directAnnotation).
PIK3R1	transfac_public__M00123	MAX; MYC (directAnnotation).
PIK3R1	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
PIK3R1	taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP	FLI1; MAX (directAnnotation).
PIK3R1	metacluster_71.1	ARNT (directAnnotation).
PIK3R1	transfac_pro__M06075	ZNF197 (directAnnotation).
PIK3R1	transfac_pro__M07043	HIF1A (directAnnotation).
PIK3R1	tfdimers__MD00493	MYB; NFE2L1 (directAnnotation).
PIK3R1	metacluster_0.7	DPRX; DPRX; DPRX; RHOXF1; RHOXF1 (directAnnotation).
PIK3R1	taipale_tf_pairs__ETV2_EOMES_RCCGGANNNNNNNNNNNACACCTN_CAP_repr	EOMES; ETV2 (directAnnotation).
PIK3R1	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
PIK3R1	metacluster_10.39	NPAS2 (inferredBy_Orthology).
PIK3R1	transfac_pro__M04853	REST (directAnnotation).
PIK3R1	cisbp__M00311	PITX2 (directAnnotation).
PIK3R1	transfac_pro__M06959	ZNF425 (directAnnotation).
PIK3R1	bergman__pho	YY1 (inferredBy_Orthology).
PIK3R1	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
PIK3R1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
PIK3R1	transfac_pro__M06651	ZNF670 (directAnnotation).
PIK3R1	taipale_tf_pairs__FOXJ2_HOXB13_RTAAACWNATWAAA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
PIK3R1	metacluster_110.2	ZNF549 (directAnnotation).
PIK3R1	transfac_pro__M05815	ZNF613 (directAnnotation).
PIK3R1	cisbp__M01802	XBP1 (inferredBy_Orthology).
PIK3R1	transfac_pro__M05854	ZNF619 (directAnnotation).
PIK3R1	dbtfbs__mm_TAL1_representative_N3	TAL1 (inferredBy_Orthology).
PIK3R1	transfac_pro__M07384	HIF1A (directAnnotation).
PIK3R1	transfac_pro__M01266	ELF1 (directAnnotation).
PIK3R1	metacluster_74.19	HNF1A (inferredBy_Orthology).
PIK3R1	transfac_pro__M06437	ZNF836 (directAnnotation).
PIK3R1	metacluster_97.2	GTF3A (inferredBy_Orthology).
PIK3R1	transfac_pro__M06584	ZNF606 (directAnnotation).
PIK3R1	transfac_pro__M06941	DDIT3 (directAnnotation).
PIK3R1	transfac_pro__M05590	ZNF772 (directAnnotation).
PIK3R1	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
PIK3R1	transfac_pro__M00687	NFYC (directAnnotation). NFYA (inferredBy_Orthology).
PIK3R1	tfdimers__MD00074	SOX4; YY2 (directAnnotation).
PIK3R1	metacluster_27.8	SOX10; SOX9 (directAnnotation).
PIK3R1	transfac_pro__M05572	ZFP91; ZFP91-CNTF (inferredBy_Orthology).
PIK3R1	swissregulon__mm__Nkx3-2	NKX3-2 (inferredBy_Orthology).
PIK3R1	cisbp__M00832	TBX1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PIK3R1	"Enzastaurin"	DB06486	small molecule
PIK3R1	"SF1126"	DB05210	small molecule
PIK3R1	"Wortmannin"	DB08059	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."