Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PIGK

Summary for PIGK

Gene information	Gene symbol	PIGK
	Ensembl ID	ENSG00000142892
	Entrez ID	10026
	Gene name	phosphatidylinositol glycan anchor biosynthesis class K
	Synonyms	GPI8\|hGPI8
	Gene type	protein_coding
	UniProtAcc	Q92643

Top

Dataset with differentially expressed gene: PIGK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.349612	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.275391	0.00e+00

Top

Expression of PIGK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PIGK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PIGK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PIGK	hsa-miR-655-3p	92.0514	NM_005482
PIGK	hsa-miR-374c-5p	92.0514	NM_005482
PIGK	hsa-miR-6780a-5p	90.7885	NM_005482
PIGK	hsa-miR-584-5p	89.3096	NM_005482
PIGK	hsa-miR-3689a-3p	89.0989	NM_005482
PIGK	hsa-miR-6779-5p	89.0989	NM_005482
PIGK	hsa-miR-3689b-3p	89.0989	NM_005482
PIGK	hsa-miR-30b-3p	89.0989	NM_005482
PIGK	hsa-miR-3689c	89.0989	NM_005482
PIGK	hsa-miR-1273h-5p	89.0989	NM_005482
PIGK	hsa-miR-7847-3p	88.7055	NM_005482
PIGK	hsa-miR-9983-3p	87.9563	NM_005482
PIGK	hsa-miR-6792-5p	87.8769	NM_005482
PIGK	hsa-miR-1277-5p	87.6307	NM_005482
PIGK	hsa-miR-369-3p	86.8841	NM_005482
PIGK	hsa-miR-3662	86.8207	NM_005482
PIGK	hsa-miR-485-3p	86.421	NM_005482
PIGK	hsa-miR-539-3p	86.421	NM_005482
PIGK	hsa-miR-2467-3p	86.0445	NM_005482
PIGK	hsa-miR-3163	85.7463	NM_005482
PIGK	hsa-miR-12136	85.4523	NM_005482
PIGK	hsa-miR-129-5p	84.8156	NM_005482
PIGK	hsa-miR-320c	84.8025	NM_005482
PIGK	hsa-miR-320d	84.8025	NM_005482
PIGK	hsa-miR-320a-3p	84.8025	NM_005482
PIGK	hsa-miR-4429	84.8025	NM_005482
PIGK	hsa-miR-320b	84.8025	NM_005482
PIGK	hsa-miR-4676-3p	84.7815	NM_005482
PIGK	hsa-miR-452-5p	84.7815	NM_005482
PIGK	hsa-miR-892c-3p	84.7815	NM_005482
PIGK	hsa-miR-4775	84.7711	NM_005482
PIGK	hsa-miR-4695-3p	83.5878	NM_005482
PIGK	hsa-miR-4668-5p	83.3593	NM_005482
PIGK	hsa-miR-548av-3p	83.012	NM_005482
PIGK	hsa-miR-4254	82.2689	NM_005482
PIGK	hsa-miR-3685	81.3991	NM_005482
PIGK	hsa-miR-548x-5p	81.2844	NM_005482
PIGK	hsa-miR-548g-5p	81.2844	NM_005482
PIGK	hsa-miR-548aj-5p	81.2844	NM_005482
PIGK	hsa-miR-548f-5p	81.2844	NM_005482
PIGK	hsa-miR-10526-3p	80.6388	NM_005482
PIGK	hsa-miR-384	80.2004	NM_005482

Page: 1

Top

Motifs and transcription factors (TFs) regulating PIGK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PIGK	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
PIGK	metacluster_22.29	NFE2 (directAnnotation).
PIGK	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PIGK	transfac_pro__M01299	MECP2 (directAnnotation).
PIGK	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PIGK	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PIGK	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PIGK	transfac_pro__M04844	MAX (directAnnotation).
PIGK	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PIGK	cisbp__M02645	ETS1 (directAnnotation).
PIGK	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."