Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PIEZO2

Summary for PIEZO2

Gene information	Gene symbol	PIEZO2
	Ensembl ID	ENSG00000154864
	Entrez ID	63895
	Gene name	piezo type mechanosensitive ion channel component 2
	Synonyms	C18orf30\|C18orf58\|FAM38B\|FAM38B2\|FLJ23144\|FLJ23403\|FLJ34907\|HsT748\|HsT771
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PIEZO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.63297	3.21e-02

Top

Expression of PIEZO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PIEZO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PIEZO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PIEZO2	hsa-miR-636	99.7403	NM_022068
PIEZO2	hsa-miR-4495	99.3554	NM_022068
PIEZO2	hsa-miR-218-5p	98.736	NM_022068
PIEZO2	hsa-miR-3714	97.8478	NM_022068
PIEZO2	hsa-miR-6885-3p	96.8798	NM_022068
PIEZO2	hsa-miR-6516-5p	96.5768	NM_022068
PIEZO2	hsa-miR-6772-3p	95.1687	NM_022068
PIEZO2	hsa-miR-9983-3p	93.6292	NM_022068
PIEZO2	hsa-miR-129-5p	93.6292	NM_022068
PIEZO2	hsa-miR-506-3p	93.2269	NM_022068
PIEZO2	hsa-miR-124-3p	93.2269	NM_022068
PIEZO2	hsa-miR-6768-5p	92.4836	NM_022068
PIEZO2	hsa-miR-3910	92.4571	NM_022068
PIEZO2	hsa-miR-5680	92.222	NM_022068
PIEZO2	hsa-miR-6779-3p	90.4412	NM_022068
PIEZO2	hsa-miR-2682-5p	90.3754	NM_022068
PIEZO2	hsa-miR-449c-5p	90.3754	NM_022068
PIEZO2	hsa-miR-34b-5p	90.3754	NM_022068
PIEZO2	hsa-miR-6826-3p	89.8952	NM_022068
PIEZO2	hsa-miR-3919	89.7497	NM_022068
PIEZO2	hsa-miR-509-5p	89.19	NM_022068
PIEZO2	hsa-miR-509-3-5p	89.19	NM_022068
PIEZO2	hsa-miR-3140-3p	88.8237	NM_022068
PIEZO2	hsa-miR-221-3p	87.7619	NM_022068
PIEZO2	hsa-miR-222-3p	87.7619	NM_022068
PIEZO2	hsa-miR-5197-3p	86.9291	NM_022068
PIEZO2	hsa-miR-4418	86.1902	NM_022068
PIEZO2	hsa-miR-3658	85.7074	NM_022068
PIEZO2	hsa-miR-8066	84.6925	NM_022068
PIEZO2	hsa-miR-554	84.6825	NM_022068
PIEZO2	hsa-miR-6736-3p	84.5049	NM_022068
PIEZO2	hsa-miR-4705	84.4493	NM_022068
PIEZO2	hsa-miR-3143	84.2092	NM_022068
PIEZO2	hsa-miR-1200	82.7412	NM_022068
PIEZO2	hsa-miR-30b-5p	82.6464	NM_022068
PIEZO2	hsa-miR-30e-5p	82.6464	NM_022068
PIEZO2	hsa-miR-30c-5p	82.6464	NM_022068
PIEZO2	hsa-miR-30d-5p	82.6464	NM_022068
PIEZO2	hsa-miR-30a-5p	82.6464	NM_022068
PIEZO2	hsa-miR-7976	81.818	NM_022068
PIEZO2	hsa-miR-548v	81.2861	NM_022068
PIEZO2	hsa-miR-187-5p	81.2861	NM_022068
PIEZO2	hsa-miR-5583-3p	81.1354	NM_022068

Page: 1

Top

Motifs and transcription factors (TFs) regulating PIEZO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PIEZO2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PIEZO2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PIEZO2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PIEZO2	transfac_pro__M04617	ZBTB7A (directAnnotation).
PIEZO2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PIEZO2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PIEZO2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PIEZO2	transfac_pro__M07387	ZBTB7A (directAnnotation).
PIEZO2	transfac_pro__M07436	WT1 (directAnnotation).
PIEZO2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PIEZO2	transfac_pro__M00716	ZBTB14 (directAnnotation).
PIEZO2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PIEZO2	hdpi__HIP2	UBE2K (directAnnotation).
PIEZO2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PIEZO2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PIEZO2	transfac_pro__M04893	TAF1 (directAnnotation).
PIEZO2	transfac_pro__M03876	ZBTB33 (directAnnotation).
PIEZO2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PIEZO2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PIEZO2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PIEZO2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PIEZO2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."