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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PID1

Summary for PID1

Gene information	Gene symbol	PID1
	Ensembl ID	ENSG00000153823
	Entrez ID	55022
	Gene name	phosphotyrosine interaction domain containing 1
	Synonyms	FLJ20701\|NYGGF4
	Gene type	protein_coding
	UniProtAcc	Q7Z2X4

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Dataset with differentially expressed gene: PID1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.288958	2.16e-04

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Expression of PID1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PID1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PID1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PID1	hsa-miR-5006-3p	96.9957	NM_001100818
PID1	hsa-miR-4755-5p	96.9957	NM_001100818
PID1	hsa-miR-186-5p	96.0134	NM_001100818
PID1	hsa-miR-204-5p	94.715	NM_001100818
PID1	hsa-miR-211-5p	94.715	NM_001100818
PID1	hsa-miR-4760-5p	91.7477	NM_001100818
PID1	hsa-miR-6882-3p	90.8113	NM_001100818
PID1	hsa-miR-4666a-3p	89.2573	NM_001100818
PID1	hsa-miR-4680-3p	88.7875	NM_001100818
PID1	hsa-miR-8061	88.5771	NM_001100818
PID1	hsa-miR-517-5p	87.2494	NM_001100818
PID1	hsa-miR-6749-3p	86.7642	NM_001100818
PID1	hsa-miR-5692c	86.2583	NM_001100818
PID1	hsa-miR-5692b	86.2583	NM_001100818
PID1	hsa-miR-5580-3p	86.0362	NM_001100818
PID1	hsa-miR-1207-3p	85.9766	NM_001100818
PID1	hsa-miR-4446-5p	85.8419	NM_001100818
PID1	hsa-miR-548h-3p	85.715	NM_001100818
PID1	hsa-miR-548bb-3p	85.715	NM_001100818
PID1	hsa-miR-548d-3p	85.715	NM_001100818
PID1	hsa-miR-548ac	85.715	NM_001100818
PID1	hsa-miR-548z	85.715	NM_001100818
PID1	hsa-miR-6875-3p	84.6644	NM_001100818
PID1	hsa-miR-6787-3p	84.1521	NM_001100818
PID1	hsa-miR-214-3p	83.6793	NM_001100818
PID1	hsa-miR-3619-5p	83.6793	NM_001100818
PID1	hsa-miR-6815-3p	83.5162	NM_001100818
PID1	hsa-miR-3664-3p	83.0347	NM_001100818
PID1	hsa-miR-3714	82.5572	NM_001100818
PID1	hsa-miR-4256	81.9283	NM_001100818
PID1	hsa-miR-11181-5p	81.9283	NM_001100818
PID1	hsa-miR-4749-3p	81.26	NM_001100818
PID1	hsa-miR-210-5p	81.26	NM_001100818
PID1	hsa-miR-1287-5p	80.901	NM_001100818
PID1	hsa-miR-548e-5p	80.6637	NM_001100818
PID1	hsa-miR-4750-3p	80.6136	NM_001100818
PID1	hsa-miR-5193	80.3778	NM_001100818

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Motifs and transcription factors (TFs) regulating PID1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PID1	transfac_pro__M03806	ZBTB7C (directAnnotation).
PID1	metacluster_198.3	ZFP64 (directAnnotation).
PID1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PID1	tfdimers__MD00483	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."