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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PICALM

Summary for PICALM

Gene information	Gene symbol	PICALM
	Ensembl ID	ENSG00000073921
	Entrez ID	8301
	Gene name	phosphatidylinositol binding clathrin assembly protein
	Synonyms	CALM\|CLTH
	Gene type	protein_coding
	UniProtAcc	Q13492

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Dataset with differentially expressed gene: PICALM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.347299	3.80e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.264789	1.45e-11

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Expression of PICALM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PICALM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PICALM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PICALM	hsa-miR-5700	99.6407	NM_001206946
PICALM	hsa-miR-651-3p	97.1414	NM_001008660
PICALM	hsa-miR-1250-3p	96.757	NM_001206946
PICALM	hsa-miR-4473	95.6541	NM_001008660
PICALM	hsa-miR-3115	94.0809	NM_001008660
PICALM	hsa-miR-376c-5p	93.5915	NM_001206946
PICALM	hsa-miR-376b-5p	93.5915	NM_001206946
PICALM	hsa-miR-30a-5p	93.2038	NM_001206946
PICALM	hsa-miR-30e-5p	93.2038	NM_001206946
PICALM	hsa-miR-30c-5p	93.2038	NM_001206946
PICALM	hsa-miR-30b-5p	93.2038	NM_001206946
PICALM	hsa-miR-30d-5p	93.2038	NM_001206946
PICALM	hsa-miR-5584-5p	93.1458	NM_001008660
PICALM	hsa-miR-6885-3p	92.968	NM_001206946
PICALM	hsa-miR-541-5p	92.6835	NM_001206946
PICALM	hsa-miR-4495	92.4266	NM_001206946
PICALM	hsa-miR-4760-3p	92.3223	NM_001008660
PICALM	hsa-miR-3119	92.2421	NM_001008660
PICALM	hsa-miR-4716-5p	91.7292	NM_001206946
PICALM	hsa-miR-548g-3p	91.7058	NM_001206946
PICALM	hsa-miR-122b-5p	91.6024	NM_001008660
PICALM	hsa-miR-5691	91.2105	NM_001008660
PICALM	hsa-miR-6805-3p	91.2105	NM_001008660
PICALM	hsa-miR-6864-5p	91.1725	NM_001206946
PICALM	hsa-miR-338-5p	90.538	NM_001206946
PICALM	hsa-miR-548at-5p	90.2914	NM_001008660
PICALM	hsa-miR-7-2-3p	89.8199	NM_001008660
PICALM	hsa-miR-7-1-3p	89.8199	NM_001008660
PICALM	hsa-miR-1179	89.454	NM_001206946
PICALM	hsa-miR-4524a-3p	89.3314	NM_001008660
PICALM	hsa-miR-664a-3p	89.2372	NM_001008660
PICALM	hsa-miR-5582-5p	89.155	NM_001008660
PICALM	hsa-miR-5688	88.4937	NM_001206946
PICALM	hsa-miR-3190-3p	87.9858	NM_001008660
PICALM	hsa-miR-3148	87.9048	NM_001008660
PICALM	hsa-miR-3685	87.7876	NM_001206946
PICALM	hsa-miR-4752	87.1279	NM_001008660
PICALM	hsa-miR-520f-3p	87.1165	NM_001008660
PICALM	hsa-miR-3161	86.6362	NM_001206946
PICALM	hsa-miR-6891-5p	86.4071	NM_001206946
PICALM	hsa-miR-384	86.3124	NM_001206946
PICALM	hsa-miR-4282	86.1279	NM_001206946
PICALM	hsa-miR-495-3p	85.9937	NM_001206946
PICALM	hsa-miR-429	85.3723	NM_001206946
PICALM	hsa-miR-513b-3p	85.2348	NM_001206946
PICALM	hsa-miR-1290	84.8456	NM_001206946
PICALM	hsa-miR-4709-5p	84.5225	NM_001008660
PICALM	hsa-miR-3121-3p	84.516	NM_001008660
PICALM	hsa-miR-4728-3p	84.4919	NM_001206946
PICALM	hsa-miR-4418	84.2835	NM_001008660

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Motifs and transcription factors (TFs) regulating PICALM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PICALM	hdpi__TIMELESS	TIMELESS (directAnnotation).
PICALM	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
PICALM	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PICALM	jaspar__MA1122.1	TFDP1 (directAnnotation).
PICALM	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
PICALM	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PICALM	transfac_pro__M01253	CNOT3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."