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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PIAS3

Summary for PIAS3

Gene informationGene symbol

PIAS3

Ensembl ID

ENSG00000131788

Entrez ID

10401

Gene nameprotein inhibitor of activated STAT 3
SynonymsFLJ14651|ZMIZ5
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: PIAS3

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.4171030.00e+00

GSE104987

MCF7 cell lineCell lineBreast cancerER+ breast cancerTargeted therapyKDM5-C70NAMalignant cells-0.2692241.19e-14

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Expression of PIAS3 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PIAS3

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

PIAS3

Unusual Activation of Pro-survival Pathway
Page: 1

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MicroRNAs (miRNA) regulating PIAS3

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PIAS3hsa-miR-1213696.6014NM_006099
PIAS3hsa-let-7c-3p90.3407NM_006099
PIAS3hsa-miR-5011-5p89.8405NM_006099
PIAS3hsa-miR-3121-3p89.7027NM_006099
PIAS3hsa-miR-4709-3p89.1532NM_006099
PIAS3hsa-miR-215-3p88.219NM_006099
PIAS3hsa-miR-4764-5p88.1144NM_006099
PIAS3hsa-miR-469285.5381NM_006099
PIAS3hsa-miR-318584.9405NM_006099
PIAS3hsa-miR-1212783.671NM_006099
PIAS3hsa-miR-18b-5p82.9718NM_006099
PIAS3hsa-miR-18a-5p82.9718NM_006099
PIAS3hsa-miR-4735-3p82.9718NM_006099
PIAS3hsa-miR-519382.6299NM_006099
PIAS3hsa-miR-3135a82.5949NM_006099
PIAS3hsa-miR-451482.4674NM_006099
PIAS3hsa-miR-6887-5p82.0774NM_006099
PIAS3hsa-miR-6795-5p82.0774NM_006099
PIAS3hsa-miR-429381.4286NM_006099
PIAS3hsa-miR-655-5p80.005NM_006099
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Motifs and transcription factors (TFs) regulating PIAS3

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PIAS3transfac_pro__M04862NRF1 (directAnnotation).
PIAS3transfac_pro__M00492STAT1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."