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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PIAS1

Summary for PIAS1

Gene informationGene symbol

PIAS1

Ensembl ID

ENSG00000033800

Entrez ID

8554

Gene nameprotein inhibitor of activated STAT 1
SynonymsDDXBP1|GBP|GU/RH-II|ZMIZ3
Gene typeprotein_coding
UniProtAcc

O75925


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Dataset with differentially expressed gene: PIAS1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells-0.3777352.35e-13

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro0.3502515.58e-11

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells-0.2648640.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.3377849.18e-35

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Expression of PIAS1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PIAS1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PIAS1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PIAS1hsa-miR-4446-5p99.7219NM_016166
PIAS1hsa-let-7f-1-3p99.452NM_001320687
PIAS1hsa-let-7b-3p99.452NM_001320687
PIAS1hsa-let-7a-3p99.452NM_001320687
PIAS1hsa-miR-98-3p99.452NM_001320687
PIAS1hsa-miR-4799-5p98.5613NM_001320687
PIAS1hsa-miR-548a-3p96.7409NM_016166
PIAS1hsa-miR-548az-3p96.7409NM_016166
PIAS1hsa-miR-548e-3p96.7409NM_016166
PIAS1hsa-miR-548f-3p96.7409NM_016166
PIAS1hsa-miR-548bc96.7409NM_016166
PIAS1hsa-miR-548ar-3p96.1951NM_016166
PIAS1hsa-miR-627-3p95.8902NM_016166
PIAS1hsa-miR-426395.1519NM_001320687
PIAS1hsa-miR-54394.7168NM_001320687
PIAS1hsa-miR-211794.5563NM_001320687
PIAS1hsa-miR-190a-3p94.4024NM_001320687
PIAS1hsa-miR-4727-5p93.945NM_016166
PIAS1hsa-miR-32-3p93.8616NM_001320687
PIAS1hsa-miR-181a-5p93.3043NM_001320687
PIAS1hsa-miR-181c-5p93.3043NM_001320687
PIAS1hsa-miR-181b-5p93.3043NM_001320687
PIAS1hsa-miR-181d-5p93.3043NM_001320687
PIAS1hsa-miR-374a-3p93.2932NM_016166
PIAS1hsa-miR-5003-3p93.2513NM_016166
PIAS1hsa-miR-426293.1119NM_001320687
PIAS1hsa-miR-990292.0922NM_016166
PIAS1hsa-miR-477591.2984NM_016166
PIAS1hsa-miR-848590.8577NM_016166
PIAS1hsa-miR-3124-3p90.7592NM_001320687
PIAS1hsa-miR-4797-5p89.8195NM_016166
PIAS1hsa-miR-942-5p89.7158NM_001320687
PIAS1hsa-miR-6501-3p87.7451NM_001320687
PIAS1hsa-miR-651-3p87.5607NM_016166
PIAS1hsa-miR-218-5p87.2897NM_001320687
PIAS1hsa-miR-493-5p86.476NM_001320687
PIAS1hsa-miR-128486.4273NM_001320687
PIAS1hsa-miR-3688-3p86.3487NM_001320687
PIAS1hsa-miR-589-5p85.7377NM_016166
PIAS1hsa-miR-5582-3p85.6193NM_016166
PIAS1hsa-miR-425184.849NM_001320687
PIAS1hsa-miR-3692-3p83.5163NM_016166
PIAS1hsa-miR-4653-5p83.3817NM_001320687
PIAS1hsa-miR-392183.3817NM_001320687
PIAS1hsa-miR-576-5p82.8144NM_001320687
PIAS1hsa-miR-30e-3p82.3115NM_016166
PIAS1hsa-miR-30a-3p82.3115NM_016166
PIAS1hsa-miR-30d-3p82.3115NM_016166
PIAS1hsa-miR-4755-5p82NM_016166
PIAS1hsa-miR-5006-3p82NM_016166
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Motifs and transcription factors (TFs) regulating PIAS1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PIAS1homer__TWVGGTCCGC_HINFPHINFP (directAnnotation).
PIAS1dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
PIAS1transfac_pro__M12686ZBTB10 (directAnnotation).
PIAS1cisbp__M00139ZNF281 (inferredBy_Orthology).
PIAS1cisbp__M00135ZBTB7B (inferredBy_Orthology).
PIAS1metacluster_198.3ZFP64 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."