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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHYHIPL

Summary for PHYHIPL

Gene information	Gene symbol	PHYHIPL
	Ensembl ID	ENSG00000165443
	Entrez ID	84457
	Gene name	phytanoyl-CoA 2-hydroxylase interacting protein like
	Synonyms	Em:AC025038.1\|KIAA1796
	Gene type	protein_coding
	UniProtAcc	Q96FC7

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Dataset with differentially expressed gene: PHYHIPL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.756553	0.00e+00

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Expression of PHYHIPL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHYHIPL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHYHIPL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHYHIPL	hsa-miR-4482-3p	98.5983	NM_001143774
PHYHIPL	hsa-miR-645	97.2812	NM_001143774
PHYHIPL	hsa-miR-4803	96.2825	NM_001143774
PHYHIPL	hsa-miR-182-5p	95.3786	NM_001143774
PHYHIPL	hsa-miR-96-5p	95.3786	NM_001143774
PHYHIPL	hsa-miR-1271-5p	95.3193	NM_001143774
PHYHIPL	hsa-miR-12133	95.3193	NM_001143774
PHYHIPL	hsa-miR-6809-3p	95.1359	NM_001143774
PHYHIPL	hsa-miR-299-5p	94.3211	NM_001143774
PHYHIPL	hsa-miR-122b-3p	94.2921	NM_001143774
PHYHIPL	hsa-miR-21-3p	94.2921	NM_001143774
PHYHIPL	hsa-miR-936	93.9063	NM_001143774
PHYHIPL	hsa-miR-496	93.7246	NM_001143774
PHYHIPL	hsa-miR-222-5p	92.3527	NM_001143774
PHYHIPL	hsa-miR-107	92.2684	NM_001143774
PHYHIPL	hsa-miR-103a-3p	92.2684	NM_001143774
PHYHIPL	hsa-miR-6828-5p	91.9635	NM_001143774
PHYHIPL	hsa-miR-6740-5p	91.9501	NM_001143774
PHYHIPL	hsa-miR-3662	91.696	NM_001143774
PHYHIPL	hsa-miR-4496	91.182	NM_001143774
PHYHIPL	hsa-miR-376a-2-5p	90.7823	NM_001143774
PHYHIPL	hsa-miR-6833-3p	90.6867	NM_001143774
PHYHIPL	hsa-miR-508-3p	90.6467	NM_001143774
PHYHIPL	hsa-miR-7844-5p	90.2497	NM_001143774
PHYHIPL	hsa-miR-6760-3p	89.8564	NM_001143774
PHYHIPL	hsa-miR-4642	89.5799	NM_001143774
PHYHIPL	hsa-miR-5590-3p	88.7872	NM_001143774
PHYHIPL	hsa-miR-142-5p	88.7872	NM_001143774
PHYHIPL	hsa-miR-4768-5p	88.7489	NM_001143774
PHYHIPL	hsa-miR-4276	88.1426	NM_001143774
PHYHIPL	hsa-miR-20b-3p	87.8031	NM_001143774
PHYHIPL	hsa-miR-559	87.6712	NM_001143774
PHYHIPL	hsa-miR-200a-3p	87.3761	NM_001143774
PHYHIPL	hsa-miR-141-3p	87.3761	NM_001143774
PHYHIPL	hsa-miR-3688-3p	86.9719	NM_001143774
PHYHIPL	hsa-miR-4639-5p	86.1233	NM_001143774
PHYHIPL	hsa-miR-4266	86.0762	NM_001143774
PHYHIPL	hsa-miR-33a-3p	85.8047	NM_001143774
PHYHIPL	hsa-miR-5692a	85.2926	NM_001143774
PHYHIPL	hsa-miR-205-5p	84.9951	NM_001143774
PHYHIPL	hsa-miR-19b-2-5p	84.8693	NM_001143774
PHYHIPL	hsa-miR-19b-1-5p	84.8693	NM_001143774
PHYHIPL	hsa-miR-4678	84.8219	NM_001143774
PHYHIPL	hsa-miR-153-5p	84.7093	NM_001143774
PHYHIPL	hsa-miR-3686	84.3395	NM_001143774
PHYHIPL	hsa-miR-7159-3p	83.9751	NM_001143774
PHYHIPL	hsa-miR-5093	83.9634	NM_001143774
PHYHIPL	hsa-miR-19a-5p	83.3492	NM_001143774
PHYHIPL	hsa-miR-561-3p	82.723	NM_001143774
PHYHIPL	hsa-miR-4299	82.6959	NM_001143774

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Motifs and transcription factors (TFs) regulating PHYHIPL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."