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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHLDB1

Summary for PHLDB1

Gene information	Gene symbol	PHLDB1
	Ensembl ID	ENSG00000019144
	Entrez ID	23187
	Gene name	pleckstrin homology like domain family B member 1
	Synonyms	FLJ00141\|KIAA0638\|LL5a
	Gene type	protein_coding
	UniProtAcc	Q86UU1

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Dataset with differentially expressed gene: PHLDB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.316255	5.51e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.289547	9.94e-14

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Expression of PHLDB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHLDB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHLDB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHLDB1	hsa-miR-4492	98.633	NM_001144758
PHLDB1	hsa-miR-762	97.4307	NM_001144758
PHLDB1	hsa-miR-4498	97.3711	NM_001144758
PHLDB1	hsa-miR-5001-5p	96.5628	NM_001144758
PHLDB1	hsa-miR-149-5p	95.5734	NM_001144758
PHLDB1	hsa-miR-7153-3p	95.4802	NM_001144758
PHLDB1	hsa-miR-3085-3p	93.7862	NM_001144758
PHLDB1	hsa-miR-3064-5p	93.7862	NM_001144758
PHLDB1	hsa-miR-6504-5p	93.7862	NM_001144758
PHLDB1	hsa-miR-6071	92.5172	NM_001144758
PHLDB1	hsa-miR-12136	91.6188	NM_001144758
PHLDB1	hsa-miR-4306	89.5151	NM_001144758
PHLDB1	hsa-miR-3135b	89.3705	NM_001144758
PHLDB1	hsa-miR-4794	87.7216	NM_001144758
PHLDB1	hsa-miR-4430	86.3338	NM_001144758
PHLDB1	hsa-miR-3652	86.3338	NM_001144758
PHLDB1	hsa-miR-4644	86.0395	NM_001144758
PHLDB1	hsa-miR-185-5p	86.0395	NM_001144758
PHLDB1	hsa-miR-6861-3p	85.5379	NM_001144758
PHLDB1	hsa-miR-5088-3p	85.0399	NM_001144758
PHLDB1	hsa-miR-93-3p	84.3663	NM_001144758
PHLDB1	hsa-miR-664a-5p	83.4366	NM_001144758
PHLDB1	hsa-miR-3649	82.9421	NM_001144758
PHLDB1	hsa-miR-520d-5p	82.7678	NM_001144758
PHLDB1	hsa-miR-524-5p	82.7678	NM_001144758
PHLDB1	hsa-miR-1263	80.3998	NM_001144758

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Motifs and transcription factors (TFs) regulating PHLDB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHLDB1	hdpi__NFIX	NFIX (directAnnotation).
PHLDB1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
PHLDB1	metacluster_74.6	HNF1A (directAnnotation).
PHLDB1	transfac_pro__M07260	IKZF1 (directAnnotation).
PHLDB1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
PHLDB1	transfac_pro__M01835	KLF4 (directAnnotation).
PHLDB1	jaspar__MA1125.1	ZNF384 (directAnnotation).
PHLDB1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
PHLDB1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PHLDB1	swissregulon__hs__MTA3	MTA3 (directAnnotation).
PHLDB1	transfac_pro__M07270	TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."