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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHF6

Summary for PHF6

Gene information	Gene symbol	PHF6
	Ensembl ID	ENSG00000156531
	Entrez ID	84295
	Gene name	PHD finger protein 6
	Synonyms	BFLS\|BORJ\|CENP-31\|KIAA1823\|MGC14797
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.277336	3.14e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279894	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.261426	4.09e-10

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Expression of PHF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHF6	hsa-miR-873-5p	98.5538	NM_001015877
PHF6	hsa-miR-216a-3p	98.501	NM_032458
PHF6	hsa-miR-3681-3p	98.501	NM_032458
PHF6	hsa-miR-128-3p	98.501	NM_032458
PHF6	hsa-miR-889-3p	98.3339	NM_032458
PHF6	hsa-miR-4799-5p	98.1301	NM_001015877
PHF6	hsa-miR-4495	97.8584	NM_032458
PHF6	hsa-miR-570-3p	96.8258	NM_032458
PHF6	hsa-miR-153-5p	95.7372	NM_032458
PHF6	hsa-miR-5688	95.2231	NM_001015877
PHF6	hsa-miR-1244	94.9738	NM_001015877
PHF6	hsa-miR-676-5p	94.1905	NM_032458
PHF6	hsa-miR-651-3p	94.1393	NM_001015877
PHF6	hsa-miR-3682-5p	94.1056	NM_032458
PHF6	hsa-miR-1297	93.9541	NM_032458
PHF6	hsa-miR-6868-3p	93.8689	NM_032458
PHF6	hsa-miR-495-3p	93.8406	NM_001015877
PHF6	hsa-miR-6088	93.7367	NM_032458
PHF6	hsa-miR-5696	93.5964	NM_032458
PHF6	hsa-miR-143-3p	93.4056	NM_032458
PHF6	hsa-miR-4770	93.4056	NM_032458
PHF6	hsa-miR-203a-3p	93.2156	NM_001015877
PHF6	hsa-miR-4776-3p	92.7488	NM_032458
PHF6	hsa-miR-203b-5p	92.6603	NM_032458
PHF6	hsa-miR-6718-5p	92.6603	NM_032458
PHF6	hsa-miR-548c-3p	92.6256	NM_032458
PHF6	hsa-miR-561-3p	92.112	NM_001015877
PHF6	hsa-miR-10399-5p	92.1042	NM_032458
PHF6	hsa-miR-452-5p	90.7134	NM_032458
PHF6	hsa-miR-6885-3p	90.4811	NM_001015877
PHF6	hsa-miR-5590-5p	90.4128	NM_001015877
PHF6	hsa-miR-8063	90.2256	NM_032458
PHF6	hsa-miR-6504-3p	90.1395	NM_032458
PHF6	hsa-miR-623	90.1012	NM_032458
PHF6	hsa-miR-892c-3p	90.037	NM_032458
PHF6	hsa-miR-4676-3p	90.037	NM_032458
PHF6	hsa-miR-4780	90.0185	NM_032458
PHF6	hsa-miR-26a-5p	89.8755	NM_032458
PHF6	hsa-miR-26b-5p	89.8755	NM_032458
PHF6	hsa-miR-377-3p	89.8581	NM_001015877
PHF6	hsa-miR-34b-5p	89.4865	NM_001015877
PHF6	hsa-miR-449c-5p	89.4865	NM_001015877
PHF6	hsa-miR-186-5p	89.4111	NM_001015877
PHF6	hsa-miR-455-3p	88.1885	NM_001015877
PHF6	hsa-miR-2682-5p	88.0243	NM_001015877
PHF6	hsa-miR-1-3p	87.9634	NM_032458
PHF6	hsa-miR-206	87.9634	NM_032458
PHF6	hsa-miR-613	87.9634	NM_032458
PHF6	hsa-miR-183-5p	87.618	NM_032458
PHF6	hsa-miR-4708-5p	87.5715	NM_032458

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Motifs and transcription factors (TFs) regulating PHF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHF6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PHF6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PHF6	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PHF6	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PHF6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PHF6	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PHF6	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PHF6	transfac_pro__M04826	EP300 (directAnnotation).
PHF6	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PHF6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PHF6	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PHF6	transfac_pro__M00652	NRF1 (directAnnotation).
PHF6	hdpi__ETV4	ETV4 (directAnnotation).
PHF6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PHF6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHF6	hdpi__ELF2	ELF2 (directAnnotation).
PHF6	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PHF6	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PHF6	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
PHF6	metacluster_183.4	ETS1 (inferredBy_Orthology).
PHF6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHF6	transfac_pro__M02089	E2F3 (directAnnotation).
PHF6	transfac_pro__M02898	SMAD3 (directAnnotation).
PHF6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PHF6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PHF6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHF6	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PHF6	hdpi__HIP2	UBE2K (directAnnotation).
PHF6	hdpi__NRL	NRL (directAnnotation).
PHF6	transfac_pro__M00430	E2F1 (directAnnotation).
PHF6	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PHF6	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PHF6	transfac_pro__M07329	SP7 (directAnnotation).
PHF6	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
PHF6	transfac_pro__M07397	ZNF148 (directAnnotation).
PHF6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PHF6	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PHF6	cisbp__M07938	E2F1 (directAnnotation).
PHF6	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PHF6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PHF6	transfac_pro__M07436	WT1 (directAnnotation).
PHF6	metacluster_3.14	WT1; WT1 (directAnnotation).
PHF6	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PHF6	transfac_pro__M01837	KLF11 (directAnnotation).
PHF6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PHF6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PHF6	transfac_pro__M07310	SP5 (directAnnotation).
PHF6	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PHF6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PHF6	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."