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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: PHF20

Summary for PHF20

Gene information	Gene symbol	PHF20
	Ensembl ID	ENSG00000025293
	Entrez ID	51230
	Gene name	PHD finger protein 20
	Synonyms	C20orf104\|dJ1121G12.1\|TDRD20A
	Gene type	protein_coding
	UniProtAcc	Q9BVI0

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Dataset with differentially expressed gene: PHF20

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.708971	5.41e-09
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.259401	3.80e-04
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.52052	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.38832	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.380491	0.00e+00

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Expression of PHF20 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHF20

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHF20

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHF20	hsa-miR-345-3p	98.9004	NM_016436
PHF20	hsa-miR-454-3p	97.4988	NM_016436
PHF20	hsa-miR-301a-3p	96.8159	NM_016436
PHF20	hsa-miR-301b-3p	96.8159	NM_016436
PHF20	hsa-miR-130a-3p	96.8159	NM_016436
PHF20	hsa-miR-4295	96.8159	NM_016436
PHF20	hsa-miR-130b-3p	96.8159	NM_016436
PHF20	hsa-miR-3666	96.8159	NM_016436
PHF20	hsa-miR-4319	95.4931	NM_016436
PHF20	hsa-miR-670-5p	95.0724	NM_016436
PHF20	hsa-miR-4275	94.7783	NM_016436
PHF20	hsa-miR-450b-5p	94.3755	NM_016436
PHF20	hsa-miR-891a-3p	94.342	NM_016436
PHF20	hsa-miR-7850-5p	93.738	NM_016436
PHF20	hsa-miR-4698	93.7107	NM_016436
PHF20	hsa-miR-6840-3p	93.4675	NM_016436
PHF20	hsa-miR-125b-5p	93.4584	NM_016436
PHF20	hsa-miR-125a-5p	93.4584	NM_016436
PHF20	hsa-miR-2115-5p	92.9787	NM_016436
PHF20	hsa-miR-152-3p	92.8414	NM_016436
PHF20	hsa-miR-148b-3p	92.8414	NM_016436
PHF20	hsa-miR-148a-3p	92.8414	NM_016436
PHF20	hsa-miR-4732-3p	92.3189	NM_016436
PHF20	hsa-miR-8057	90.9307	NM_016436
PHF20	hsa-miR-450a-1-3p	90.5973	NM_016436
PHF20	hsa-miR-3662	89.3919	NM_016436
PHF20	hsa-miR-6875-3p	88.3561	NM_016436
PHF20	hsa-miR-6504-3p	87.8767	NM_016436
PHF20	hsa-miR-19b-2-5p	85.9859	NM_016436
PHF20	hsa-miR-19a-5p	85.9859	NM_016436
PHF20	hsa-miR-19b-1-5p	85.9859	NM_016436
PHF20	hsa-miR-3121-3p	85.9119	NM_016436
PHF20	hsa-miR-655-5p	85.7832	NM_016436
PHF20	hsa-miR-1255b-2-3p	85.3059	NM_016436
PHF20	hsa-miR-12114	85.2311	NM_016436
PHF20	hsa-miR-3132	84.9819	NM_016436
PHF20	hsa-miR-10399-5p	84.9127	NM_016436
PHF20	hsa-miR-376c-3p	84.0734	NM_016436
PHF20	hsa-miR-3977	83.8847	NM_016436
PHF20	hsa-miR-1825	83.2294	NM_016436
PHF20	hsa-miR-196a-5p	83.187	NM_016436
PHF20	hsa-miR-196b-5p	83.187	NM_016436
PHF20	hsa-miR-26b-3p	82.549	NM_016436
PHF20	hsa-miR-197-5p	81.6205	NM_016436
PHF20	hsa-miR-6767-3p	81.3067	NM_016436
PHF20	hsa-miR-137-3p	80.8617	NM_016436
PHF20	hsa-miR-5693	80.7002	NM_016436
PHF20	hsa-miR-6844	80.2005	NM_016436
PHF20	hsa-miR-107	80.0508	NM_016436
PHF20	hsa-miR-103a-3p	80.0508	NM_016436

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Motifs and transcription factors (TFs) regulating PHF20

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHF20	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHF20	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PHF20	jaspar__MA0079.5	SP1 (directAnnotation).
PHF20	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PHF20	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PHF20	metacluster_3.14	WT1; WT1 (directAnnotation).
PHF20	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PHF20	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PHF20	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PHF20	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PHF20	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PHF20	jaspar__MA0748.2	YY2 (directAnnotation).
PHF20	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
PHF20	metacluster_166.4	down	Malignant cells	GSE108397	NA
PHF20	metacluster_166.4	down	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."