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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHACTR2

Summary for PHACTR2

Gene information	Gene symbol	PHACTR2
	Ensembl ID	ENSG00000112419
	Entrez ID	9749
	Gene name	phosphatase and actin regulator 2
	Synonyms	C6orf56\|KIAA0680
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PHACTR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.321663	2.71e-11
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.273076	0.00e+00

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Expression of PHACTR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHACTR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHACTR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHACTR2	hsa-miR-190a-3p	100	NM_001100165
PHACTR2	hsa-miR-5011-5p	100	NM_001100165
PHACTR2	hsa-miR-30d-3p	98.4121	NM_001100164
PHACTR2	hsa-miR-30e-3p	98.4121	NM_001100164
PHACTR2	hsa-miR-30a-3p	98.4121	NM_001100164
PHACTR2	hsa-miR-653-3p	97.4484	NM_001100164
PHACTR2	hsa-miR-4803	96.8772	NM_001100165
PHACTR2	hsa-miR-6504-3p	96.6214	NM_001100165
PHACTR2	hsa-miR-101-3p	95.9837	NM_001100164
PHACTR2	hsa-miR-548x-3p	95.7179	NM_001100165
PHACTR2	hsa-miR-548aj-3p	95.7179	NM_001100165
PHACTR2	hsa-miR-548ae-3p	95.6463	NM_001100165
PHACTR2	hsa-miR-548ah-3p	95.6463	NM_001100165
PHACTR2	hsa-miR-548aq-3p	95.6463	NM_001100165
PHACTR2	hsa-miR-548am-3p	95.6463	NM_001100165
PHACTR2	hsa-miR-548j-3p	95.6463	NM_001100165
PHACTR2	hsa-miR-5584-5p	95.404	NM_001100165
PHACTR2	hsa-miR-10399-5p	95.1096	NM_001100165
PHACTR2	hsa-miR-6885-3p	94.7293	NM_001100164
PHACTR2	hsa-miR-5692a	94.6921	NM_001100164
PHACTR2	hsa-miR-3128	94.6445	NM_001100164
PHACTR2	hsa-miR-4799-3p	94.6227	NM_001100164
PHACTR2	hsa-miR-3121-3p	94.3563	NM_001100165
PHACTR2	hsa-miR-5588-5p	94.3013	NM_001100164
PHACTR2	hsa-miR-3065-5p	94.2442	NM_001100165
PHACTR2	hsa-miR-381-3p	94.1122	NM_001100164
PHACTR2	hsa-miR-300	94.1122	NM_001100164
PHACTR2	hsa-miR-6740-3p	93.8495	NM_001100164
PHACTR2	hsa-miR-4251	93.7611	NM_001100164
PHACTR2	hsa-miR-4720-5p	93.2966	NM_001100164
PHACTR2	hsa-miR-33b-5p	93.2277	NM_001100165
PHACTR2	hsa-miR-33a-5p	93.2277	NM_001100165
PHACTR2	hsa-miR-506-3p	93.1779	NM_001100164
PHACTR2	hsa-miR-124-3p	93.1779	NM_001100164
PHACTR2	hsa-miR-6806-5p	92.8768	NM_001100165
PHACTR2	hsa-miR-4307	92.7063	NM_001100165
PHACTR2	hsa-miR-3658	92.6879	NM_001100165
PHACTR2	hsa-miR-6721-5p	92.5853	NM_001100165
PHACTR2	hsa-miR-5696	92.5478	NM_001100165
PHACTR2	hsa-miR-4477b	92.5055	NM_001100165
PHACTR2	hsa-miR-579-3p	92.2738	NM_001100165
PHACTR2	hsa-miR-664b-3p	92.2738	NM_001100165
PHACTR2	hsa-miR-5197-5p	92.0689	NM_001100165
PHACTR2	hsa-miR-597-3p	91.7358	NM_001100165
PHACTR2	hsa-miR-335-3p	91.4424	NM_001100165
PHACTR2	hsa-miR-4328	91.4382	NM_001100165
PHACTR2	hsa-miR-4482-3p	91.3413	NM_001100165
PHACTR2	hsa-miR-3119	91.325	NM_001100164
PHACTR2	hsa-miR-3185	91.323	NM_001100164
PHACTR2	hsa-miR-10522-5p	90.9984	NM_001100164

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Motifs and transcription factors (TFs) regulating PHACTR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHACTR2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PHACTR2	hdpi__TP73	TP73 (directAnnotation).
PHACTR2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHACTR2	transfac_pro__M04826	EP300 (directAnnotation).
PHACTR2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PHACTR2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
PHACTR2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHACTR2	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PHACTR2	jaspar__MA0748.2	YY2 (directAnnotation).
PHACTR2	transfac_pro__M06117	ZNF23 (directAnnotation).
PHACTR2	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."