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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PGM3

Summary for PGM3

Gene information	Gene symbol	PGM3
	Ensembl ID	ENSG00000013375
	Entrez ID	5238
	Gene name	phosphoglucomutase 3
	Synonyms	AGM1\|DKFZP434B187\|PAGM
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PGM3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.310851	3.14e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.33277	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.268369	2.66e-19

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Expression of PGM3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PGM3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PGM3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PGM3	hsa-miR-3664-3p	95.9921	NM_001199917
PGM3	hsa-miR-6874-3p	91.7421	NM_001199917
PGM3	hsa-miR-148b-5p	91.7421	NM_001199917
PGM3	hsa-miR-4775	91.2902	NM_001199918
PGM3	hsa-miR-873-3p	90.7979	NM_001199917
PGM3	hsa-miR-340-5p	90.5031	NM_001199917
PGM3	hsa-miR-5187-3p	90.0823	NM_001199918
PGM3	hsa-miR-568	88.2003	NM_001199918
PGM3	hsa-miR-5582-3p	87.6167	NM_001199918
PGM3	hsa-miR-30d-5p	87.4862	NM_001199917
PGM3	hsa-miR-30b-5p	87.4862	NM_001199917
PGM3	hsa-miR-30e-5p	87.4862	NM_001199917
PGM3	hsa-miR-30c-5p	87.4862	NM_001199917
PGM3	hsa-miR-30a-5p	87.4862	NM_001199917
PGM3	hsa-miR-548ar-3p	87.3571	NM_001199917
PGM3	hsa-miR-944	87.0606	NM_001199917
PGM3	hsa-miR-4457	87.0206	NM_001199917
PGM3	hsa-miR-548g-5p	87.003	NM_001199918
PGM3	hsa-miR-548aj-5p	87.003	NM_001199918
PGM3	hsa-miR-548x-5p	87.003	NM_001199918
PGM3	hsa-miR-302f	86.8911	NM_001199917
PGM3	hsa-miR-335-5p	86.7423	NM_001199917
PGM3	hsa-miR-6507-3p	86.3433	NM_001199917
PGM3	hsa-miR-10395-3p	86.3325	NM_001199918
PGM3	hsa-miR-3158-5p	85.5883	NM_001199918
PGM3	hsa-miR-4261	85.2159	NM_001199917
PGM3	hsa-miR-147b-5p	85.0425	NM_001199917
PGM3	hsa-miR-6513-3p	83.46	NM_001199917
PGM3	hsa-miR-27b-5p	83.2913	NM_001199917
PGM3	hsa-miR-3663-3p	83.0143	NM_001199918
PGM3	hsa-miR-3658	82.6708	NM_001199917
PGM3	hsa-miR-4652-3p	82.4307	NM_001199917
PGM3	hsa-miR-297	81.6495	NM_001199918
PGM3	hsa-miR-125a-3p	81.6371	NM_001199917
PGM3	hsa-miR-3149	81.481	NM_001199918
PGM3	hsa-miR-8080	81.4037	NM_001199918
PGM3	hsa-miR-4668-3p	80.883	NM_001199918
PGM3	hsa-miR-190a-3p	80.8749	NM_001199917
PGM3	hsa-miR-219a-2-3p	80.8398	NM_001199917
PGM3	hsa-miR-548f-5p	80.4743	NM_001199918
PGM3	hsa-miR-548p	80.448	NM_001199917
PGM3	hsa-miR-596	80.3684	NM_001199917
PGM3	hsa-miR-302d-5p	80.1488	NM_001199917
PGM3	hsa-miR-302b-5p	80.1488	NM_001199917

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Motifs and transcription factors (TFs) regulating PGM3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."