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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PFDN4

Summary for PFDN4

Gene information	Gene symbol	PFDN4
	Ensembl ID	ENSG00000101132
	Entrez ID	5203
	Gene name	prefoldin subunit 4
	Synonyms	C-1\|C1\|PFD4
	Gene type	protein_coding
	UniProtAcc	Q9NQP4

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Dataset with differentially expressed gene: PFDN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.609383	2.79e-11
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.671616	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.443287	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.871416	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.596203	0.00e+00

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Expression of PFDN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PFDN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PFDN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PFDN4	hsa-miR-3163	99.6565	NM_002623
PFDN4	hsa-miR-5692a	99.1209	NM_002623
PFDN4	hsa-miR-587	95.111	NM_002623
PFDN4	hsa-miR-411-3p	94.8212	NM_002623
PFDN4	hsa-miR-379-3p	94.8212	NM_002623
PFDN4	hsa-miR-1468-3p	93.5527	NM_002623
PFDN4	hsa-miR-3658	91.8226	NM_002623
PFDN4	hsa-miR-7-1-3p	91.7311	NM_002623
PFDN4	hsa-miR-7-2-3p	91.7311	NM_002623
PFDN4	hsa-miR-4799-5p	91.7064	NM_002623
PFDN4	hsa-miR-885-5p	90.8452	NM_002623
PFDN4	hsa-miR-4495	90.4977	NM_002623
PFDN4	hsa-miR-579-3p	90.1078	NM_002623
PFDN4	hsa-miR-664b-3p	90.1078	NM_002623
PFDN4	hsa-miR-12136	89.2334	NM_002623
PFDN4	hsa-miR-1297	88.7599	NM_002623
PFDN4	hsa-miR-6740-3p	88.5605	NM_002623
PFDN4	hsa-miR-3646	86.5073	NM_002623
PFDN4	hsa-miR-26b-5p	86.2642	NM_002623
PFDN4	hsa-miR-26a-5p	86.2642	NM_002623
PFDN4	hsa-miR-4282	84.9831	NM_002623
PFDN4	hsa-miR-548x-5p	84.8854	NM_002623
PFDN4	hsa-miR-548g-5p	84.8854	NM_002623
PFDN4	hsa-miR-548f-5p	84.8854	NM_002623
PFDN4	hsa-miR-548aj-5p	84.8854	NM_002623
PFDN4	hsa-miR-548ad-3p	83.8801	NM_002623
PFDN4	hsa-miR-4465	83.0947	NM_002623
PFDN4	hsa-miR-5692c	82.1013	NM_002623
PFDN4	hsa-miR-5692b	82.1013	NM_002623
PFDN4	hsa-miR-567	81.9116	NM_002623
PFDN4	hsa-miR-6771-3p	81.3292	NM_002623

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Motifs and transcription factors (TFs) regulating PFDN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PFDN4	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
PFDN4	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PFDN4	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PFDN4	metacluster_182.10	ZFX (directAnnotation).
PFDN4	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
PFDN4	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
PFDN4	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."