Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PER1

Summary for PER1

Gene information	Gene symbol	PER1
	Ensembl ID	ENSG00000179094
	Entrez ID	5187
	Gene name	period circadian regulator 1
	Synonyms	PER\|RIGUI
	Gene type	protein_coding
	UniProtAcc	O15534

Top

Dataset with differentially expressed gene: PER1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.261343	5.96e-38
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.662837	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Mono/Macro	-1.00169	4.53e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.633807	1.28e-43
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.770127	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.64399	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.32852	6.73e-33
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.527675	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.372548	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.303292	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.308176	3.42e-09

Top

Expression of PER1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PER1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PER1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PER1	hsa-miR-3149	93.1746	NM_002616
PER1	hsa-miR-646	91.3847	NM_002616
PER1	hsa-miR-10395-3p	91.2022	NM_002616
PER1	hsa-miR-4251	89.0153	NM_002616
PER1	hsa-miR-1207-3p	88.7545	NM_002616
PER1	hsa-miR-4719	88.2821	NM_002616
PER1	hsa-miR-24-3p	87.0141	NM_002616
PER1	hsa-miR-3913-5p	86.2167	NM_002616
PER1	hsa-miR-3122	86.2167	NM_002616
PER1	hsa-miR-4516	86.1801	NM_002616
PER1	hsa-miR-1233-5p	82.4094	NM_002616
PER1	hsa-miR-6778-5p	82.4094	NM_002616
PER1	hsa-miR-1302	82.3795	NM_002616
PER1	hsa-miR-4291	81.6133	NM_002616
PER1	hsa-miR-6731-5p	81.227	NM_002616
PER1	hsa-miR-8085	81.227	NM_002616
PER1	hsa-miR-4298	80.1474	NM_002616

Page: 1

Top

Motifs and transcription factors (TFs) regulating PER1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PER1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
PER1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
PER1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
PER1	jaspar__MA0748.2	YY2 (directAnnotation).
PER1	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
PER1	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
PER1	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
PER1	transfac_pro__M07284	ERG (directAnnotation).
PER1	hocomoco__NFAT5_HUMAN.H11MO.0.D	NFAT5 (directAnnotation).
PER1	metacluster_190.7	ILF2; NFATC1; NFATC1; NFATC1; NFATC1; NFATC2; NFATC2; NFATC2; NFATC3; NFATC3; NFATC3; NFATC3; NFATC4; NFATC4; NFATC4 (directAnnotation).
PER1	swissregulon__hs__NFATC2	NFATC2 (directAnnotation).
PER1	transfac_pro__M07608	ILF2; NFAT5; NFATC1; NFATC2; NFATC4 (directAnnotation).
PER1	transfac_pro__M01886	NFATC3 (directAnnotation).
PER1	hocomoco__NFAC2_MOUSE.H11MO.1.C	NFATC2 (inferredBy_Orthology).
PER1	hocomoco__NFKB1_HUMAN.H11MO.0.A	NFKB1 (directAnnotation).
PER1	transfac_pro__M07607	NFATC3 (directAnnotation).
PER1	c2h2_zfs__M0369	BCL6B (inferredBy_Orthology).
PER1	transfac_pro__M05380	NR2E1 (inferredBy_Orthology).
PER1	transfac_pro__M07301	NFATC4 (directAnnotation).
PER1	swissregulon__hs__CUX1	CUX1 (directAnnotation).
PER1	swissregulon__hs__HSF2	HSF2 (directAnnotation).
PER1	metacluster_130.12	ZNF182; ZNF35; ZNF674; ZNF677; ZNF79; ZNF836 (directAnnotation).
PER1	jaspar__MA1489.1	FOXN3 (directAnnotation).
PER1	transfac_pro__M02027	PARP1 (directAnnotation).
PER1	hocomoco__ETS2_HUMAN.H11MO.0.B	ETS2 (directAnnotation).
PER1	kznf__ZNF415_Isakova2017_SMiLE-seq	ZNF415 (directAnnotation).
PER1	metacluster_141.4	GLIS2 (directAnnotation).
PER1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
PER1	transfac_pro__M00652	NRF1 (directAnnotation).
PER1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PER1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PER1	transfac_pro__M06259	ZNF91 (directAnnotation).
PER1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PER1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PER1	transfac_pro__M07260	IKZF1 (directAnnotation).
PER1	transfac_pro__M01835	KLF4 (directAnnotation).
PER1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PER1	swissregulon__hs__MTA3	MTA3 (directAnnotation).
PER1	transfac_pro__M05993	ZNF711 (directAnnotation).
PER1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
PER1	transfac_pro__M01861	ATF1 (directAnnotation).
PER1	transfac_public__M00039	CREB1 (directAnnotation).
PER1	transfac_public__M00040	ATF2 (directAnnotation).
PER1	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
PER1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
PER1	transfac_public__M00041	ATF2; JUN (directAnnotation).
PER1	transfac_pro__M04746	E2F1 (directAnnotation).
PER1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
PER1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."