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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PEA15

Summary for PEA15

Gene information	Gene symbol	PEA15
	Ensembl ID	ENSG00000162734
	Entrez ID	8682
	Gene name	proliferation and apoptosis adaptor protein 15
	Synonyms	HMAT1\|HUMMAT1H\|MAT1\|MAT1H\|PEA-15\|PED\|PED-PEA15\|PED/PEA15
	Gene type	protein_coding
	UniProtAcc	Q15121

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Dataset with differentially expressed gene: PEA15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.259259	4.07e-36
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.554123	2.31e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.281597	5.06e-30
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.254464	9.08e-07
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.290443	4.25e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.670003	7.99e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.593681	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.751039	0.00e+00

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Expression of PEA15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PEA15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PEA15	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PEA15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PEA15	hsa-miR-6875-3p	96.2518	NM_001297576
PEA15	hsa-miR-3668	95.9599	NM_001297578
PEA15	hsa-miR-2116-3p	95.1648	NM_001297578
PEA15	hsa-miR-610	94.1729	NM_001297576
PEA15	hsa-miR-3714	92.7913	NM_001297576
PEA15	hsa-miR-7110-3p	92.4001	NM_001297578
PEA15	hsa-miR-6887-3p	91.5296	NM_001297578
PEA15	hsa-miR-5193	91.5043	NM_001297578
PEA15	hsa-miR-6721-5p	91.4707	NM_001297576
PEA15	hsa-miR-6867-5p	90.1527	NM_001297578
PEA15	hsa-miR-506-3p	88.3696	NM_001297576
PEA15	hsa-miR-124-3p	88.3696	NM_001297576
PEA15	hsa-miR-7847-3p	87.6313	NM_001297578
PEA15	hsa-miR-4653-5p	87.2819	NM_001297576
PEA15	hsa-miR-3921	87.2819	NM_001297576
PEA15	hsa-miR-4268	87.0902	NM_001297578
PEA15	hsa-miR-4774-3p	86.7301	NM_001297576
PEA15	hsa-miR-4305	86.6848	NM_001297578
PEA15	hsa-miR-3922-3p	86.4439	NM_001297578
PEA15	hsa-miR-3928-3p	86.3057	NM_001297578
PEA15	hsa-miR-33a-3p	85.7773	NM_001297578
PEA15	hsa-miR-3176	85.6985	NM_001297578
PEA15	hsa-miR-532-3p	84.0032	NM_001297578
PEA15	hsa-miR-3910	83.8341	NM_001297576
PEA15	hsa-miR-34a-5p	83.7888	NM_001297578
PEA15	hsa-miR-449a	83.7888	NM_001297578
PEA15	hsa-miR-3152-5p	83.4016	NM_001297576
PEA15	hsa-miR-4736	83.3565	NM_001297576
PEA15	hsa-miR-4733-5p	82.8351	NM_001297578
PEA15	hsa-miR-6815-3p	82.7239	NM_001297576
PEA15	hsa-miR-940	82.309	NM_001297576
PEA15	hsa-miR-6893-5p	82.309	NM_001297576
PEA15	hsa-miR-6808-5p	82.309	NM_001297576
PEA15	hsa-miR-449b-5p	81.6324	NM_001297578
PEA15	hsa-miR-34c-5p	81.6324	NM_001297578
PEA15	hsa-miR-149-5p	80.3821	NM_001297576

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Motifs and transcription factors (TFs) regulating PEA15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PEA15	jaspar__MA0079.5	SP1 (directAnnotation).
PEA15	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PEA15	transfac_pro__M04950	EGR1 (directAnnotation).
PEA15	transfac_pro__M00652	NRF1 (directAnnotation).
PEA15	hdpi__FLI1	FLI1 (directAnnotation).
PEA15	jaspar__MA1933.1	SREBF2 (directAnnotation).
PEA15	cisbp__M08198	ELF1 (directAnnotation).
PEA15	transfac_pro__M04948	HNF4G (directAnnotation).
PEA15	transfac_pro__M06180	ZNF445 (directAnnotation).
PEA15	tfdimers__MD00545	ETS1; SOX10 (directAnnotation).
PEA15	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
PEA15	transfac_pro__M05422	FOXD4L4 (directAnnotation).
PEA15	transfac_pro__M01266	ELF1 (directAnnotation).
PEA15	jaspar__MA0035.4	GATA1 (directAnnotation).
PEA15	transfac_pro__M06246	ZNF177 (directAnnotation).
PEA15	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
PEA15	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2	SPIB; TEAD4 (directAnnotation).
PEA15	taipale_tf_pairs__TEAD4_SPDEF_RGWATSCGGATGNNNNTCCKNNN_CAP_repr	SPDEF; TEAD4 (directAnnotation).
PEA15	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
PEA15	metacluster_150.4	SKOR1; SKOR1; SKOR2; SKOR2 (directAnnotation).
PEA15	cisbp__M00249	WT1 (directAnnotation).
PEA15	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
PEA15	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
PEA15	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
PEA15	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
PEA15	transfac_pro__M05803	ZNF584 (directAnnotation).
PEA15	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
PEA15	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
PEA15	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."